Keyword

Keap1

Description: KEAP1 is a protein that regulates cellular antioxidant responses by controlling the activity and degradation of the transcription factor NRF2.

Primary topic: Genomics, phytochemicals, and oxidative stress (41%)

Wikidata ID: wiki/Q18034700

OpenAlex ID: keywords/keap1

Improved vectors and genome-wide libraries for CRISPR screening

2014 · Neville E Sanjana, Ophir Shalem, et al. · Nature Methods · 5,225

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Comprehensive genomic characterization of squamous cell lung cancers

2012 · Peter S. Hammerman, Michael S. Lawrence, et al. · Nature · 3,972

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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

2006 · Thomas W. Kensler, Nobunao Wakabayashi, et al. · The Annual Review of Pharmacology and Toxicology · 3,616

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 · Ken Itoh, Nobunao Wakabayashi, et al. · Genes & Development · 3,609

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The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

2009 · Truyen Nguyen, Paul Nioi, et al. · Journal of Biological Chemistry · 2,648

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

2010 · Masaaki Komatsu, Hirofumi Kurokawa, et al. · Nature Cell Biology · 2,410

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

2004 · Akira Kobayashi, Moon-Il Kang, et al. · Molecular and Cellular Biology · 2,215

Nrf2-Keap1 signaling in oxidative and reductive stress

2018 · Ilaria Bellezza, Ileana Giambanco, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2,062

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Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts

1986 · Barry Halliwell, John M.C. Gutteridge · Archives of Biochemistry and Biophysics · 2,038

Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

2015 · Xiaofang Sun, Zhanhui Ou, et al. · Hepatology · 2,007

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The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

2018 · Masayuki Yamamoto, Thomas W. Kensler, et al. · Physiological Reviews · 1,944

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

2002 · Albena T. Dinkova-Kostova, W. David Holtzclaw, et al. · Proceedings of the National Academy of Sciences · 1,938

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

2018 · Evanna L. Mills, Dylan G. Ryan, et al. · Nature · 1,870

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Nrf2–Keap1 defines a physiologically important stress response mechanism

2004 · Hozumi Motohashi, Masayuki Yamamoto · Trends in Molecular Medicine · 1,721

Nrf2:INrf2 (Keap1) signaling in oxidative stress

2009 · James W. Kaspar, Suryakant K. Niture, et al. · Free Radical Biology and Medicine · 1,647

The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway

2020 · Liam Baird, Masayuki Yamamoto · Molecular and Cellular Biology · 1,550

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution

2011 · Keiko Taguchi, Hozumi Motohashi, et al. · Genes to Cells · 1,476

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

2003 · Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 1,475

p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

2010 · Ashish Jain, Trond Lamark, et al. · Journal of Biological Chemistry · 1,466

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Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

2019 · Antonio Cuadrado, Ana I. Rojo, et al. · Nature Reviews Drug Discovery · 1,441

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An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

2020 · Sarmistha Saha, Brigitta Buttari, et al. · Molecules · 1,394

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The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer

2013 · Emilia Kansanen, Suvi M. Kuosmanen, et al. · Redox Biology · 1,312

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

2020 · Guang Lei, Yilei Zhang, et al. · Cell Research · 1,311

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The emerging role of the Nrf2–Keap1 signaling pathway in cancer

2013 · Melba C. Jaramillo, Donna D. Zhang · Genes & Development · 1,297

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Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex

2004 · Donna D. Zhang, Shih-Ching Lo, et al. · Molecular and Cellular Biology · 1,256

Works count: 7,127

Citation count: 292,300