Keyword

KIT mutations

Description: Genetic alterations in the KIT gene, which encodes a receptor tyrosine kinase and can affect cancer development or treatment response.

Primary topic: Gastrointestinal Tumor Research and Treatment (45%)

Wikidata ID: wiki/Q28445077

OpenAlex ID: keywords/kit-mutations

Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors

1998 · Seiichi Hirota, Koji Isozaki, et al. · Science · 4,493

Diagnosis of gastrointestinal stromal tumors: A consensus approach

2002 · Christopher D.M. Fletcher, Jules J. Berman, et al. · Human Pathology · 3,420

Genomic Classification of Cutaneous Melanoma

2015 · Rehan Akbani, Kadir C. Akdemir, et al. · Cell · 3,142

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Kinase Mutations and Imatinib Response in Patients With Metastatic Gastrointestinal Stromal Tumor

2003 · Michael C. Heinrich, Christopher L. Corless, et al. · Journal of Clinical Oncology · 2,300

Somatic Activation of KIT in Distinct Subtypes of Melanoma

2006 · John A. Curtin, Klaus Busam, et al. · Journal of Clinical Oncology · 1,617

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Biology of Gastrointestinal Stromal Tumors

2004 · Christopher L. Corless, Jonathan A. Fletcher, et al. · Journal of Clinical Oncology · 1,228

Gastrointestinal stromal tumour

2007 · Brian P Rubin, Michael C Heinrich, et al. · The Lancet · 1,046

Long-Term Results From a Randomized Phase II Trial of Standard- Versus Higher-Dose Imatinib Mesylate for Patients With Unresectable or Metastatic Gastrointestinal Stromal Tumors Expressing KIT

2008 · Charles D. Blanke, George D. Demetri, et al. · Journal of Clinical Oncology · 996

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One vs Three Years of Adjuvant Imatinib for Operable Gastrointestinal Stromal Tumor

2012 · Heikki Joensuu, Mikael Eriksson, et al. · JAMA · 981

KIT activation is a ubiquitous feature of gastrointestinal stromal tumors.

2001 · B P Rubin, S Singer, et al. · PubMed · 962

KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours

2006 · Maria Debiec-Rychter, Raf Sciot, et al. · European Journal of Cancer · 892

KIT as a Therapeutic Target in Metastatic Melanoma

2011 · Richard D. Carvajal · JAMA · 888

PDGFRA Mutations in Gastrointestinal Stromal Tumors: Frequency, Spectrum and In Vitro Sensitivity to Imatinib

2005 · Christopher L. Corless, Arin Schroeder, et al. · Journal of Clinical Oncology · 849

Molecular Correlates of Imatinib Resistance in Gastrointestinal Stromal Tumors

2006 · Michael C. Heinrich, Christopher L. Corless, et al. · Journal of Clinical Oncology · 814

Primary and Secondary Kinase Genotypes Correlate With the Biological and Clinical Activity of Sunitinib in Imatinib-Resistant Gastrointestinal Stromal Tumor

2008 · Michael C. Heinrich, Robert G. Maki, et al. · Journal of Clinical Oncology · 798

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Consensus meeting for the management of gastrointestinal stromal tumors Report of the GIST Consensus Conference of 20–21 March 2004, under the auspices of ESMO

2005 · J.-Y. Blay, S. Bonvalot, et al. · Annals of Oncology · 722

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

2005 · Susanne Schnittger, Claudia Schoch, et al. · Blood · 713

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Gastrointestinal stromal tumour

2013 · Heikki Joensuu, Peter Hohenberger, et al. · The Lancet · 703

STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications

2001 · David A Tuveson, Nicholas A Willis, et al. · Oncogene · 695

Phase II, Open-Label, Single-Arm Trial of Imatinib Mesylate in Patients With Metastatic Melanoma Harboring c-Kit Mutation or Amplification

2011 · Jun Guo, Lu Si, et al. · Journal of Clinical Oncology · 688

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Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: A review

2002 · Markku Miettinen, Wa'El El-Rifai, et al. · Human Pathology · 664

Adverse Prognostic Significance of KIT Mutations in Adult Acute Myeloid Leukemia With inv(16) and t(8;21): A Cancer and Leukemia Group B Study

2006 · Peter Paschka, Guido Marcucci, et al. · Journal of Clinical Oncology · 663

The Novel Marker, DOG1, Is Expressed Ubiquitously in Gastrointestinal Stromal Tumors Irrespective of KIT or PDGFRA Mutation Status

2004 · Robert B. West, Christopher L. Corless, et al. · American Journal Of Pathology · 659

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KIT Gene Mutations and Copy Number in Melanoma Subtypes

2008 · Carol Beadling, Erick Jacobson-Dunlop, et al. · Clinical Cancer Research · 647

Clinical management of gastrointestinal stromal tumors: Before and after STI-571

2002 · Ronald P. Dematteo, Michael C. Heinrich, et al. · Human Pathology · 637

Works count: 5,927

Citation count: 153,100