Keyword

Mitragyna speciosa

Description: A tropical tree species native to Southeast Asia, commonly known as kratom, whose leaves contain psychoactive compounds and have traditional uses.

Primary topic: Alkaloids: synthesis and pharmacology (55%)

Wikidata ID: wiki/Q139698

OpenAlex ID: keywords/kratom

From Kratom to mitragynine and its derivatives: Physiological and behavioural effects related to use, abuse, and addiction

2012 · Zurina Hassan, Mustapha Muzaimi, et al. · Neuroscience & Biobehavioral Reviews · 386

Chemistry and Pharmacology of Analgesic Indole Alkaloids from the Rubiaceous Plant, Mitragyna speciosa

2004 · Hiromitsu Takayama · Chemical and Pharmaceutical Bulletin · 356

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Here Today, Gone Tomorrow…and Back Again? A Review of Herbal Marijuana Alternatives (K2, Spice), Synthetic Cathinones (Bath Salts), Kratom, Salvia divinorum, Methoxetamine, and Piperazines

2012 · Christopher D. Rosenbaum, Stephanie P. Carreiro, et al. · Journal of Medical Toxicology · 355

Self‐treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)

2008 · Edward W. Boyer, Kavita M. Babu, et al. · Addiction · 343

Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2

2016 · András Váradi, Gina F. Marrone, et al. · Journal of Medicinal Chemistry · 324

Patterns of Kratom use and health impact in the US—Results from an online survey

2017 · Oliver Grundmann · Drug and Alcohol Dependence · 310

Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds

2010 · Sebastian Dresen, Nerea Ferreirós, et al. · Journal of Mass Spectrometry · 309

Studies on the Synthesis and Opioid Agonistic Activities of Mitragynine-Related Indole Alkaloids: Discovery of Opioid Agonists Structurally Different from Other Opioid Ligands

2002 · Hiromitsu Takayama, Hayato Ishikawa, et al. · Journal of Medicinal Chemistry · 273

Pharmacology of kratom: an emerging botanical agent with stimulant, analgesic and opioid-like effects.

2012 · Walter C Prozialeck, Jateen K Jivan, et al. · PubMed · 250

Kratom (Mitragyna speciosa) dependence, withdrawal symptoms and craving in regular users

2014 · Darshan Singh, Christian P. Müller, et al. · Drug and Alcohol Dependence · 249

A study of kratom eaters in Thailand.

1976 · S Suwanlert · PubMed · 245

The informal use of ketum (Mitragyna speciosa) for opioid withdrawal in the northern states of peninsular Malaysia and implications for drug substitution therapy

2010 · Balasingam Vicknasingam, Suresh Narayanan, et al. · International Journal of Drug Policy · 244

Following “the Roots” of Kratom ( Mitragyna speciosa ): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries

2015 · Eduardo Cinosi, Giovanni Martinotti, et al. · BioMed Research International · 234

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The medicinal chemistry and neuropharmacology of kratom: A preliminary discussion of a promising medicinal plant and analysis of its potential for abuse

2017 · Andrew C. Kruegel, Oliver Grundmann · Neuropharmacology · 231

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

2019 · Andrew C. Kruegel, Rajendra Uprety, et al. · ACS Central Science · 229

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Antinociceptive effect of 7-hydroxymitragynine in mice: Discovery of an orally active opioid analgesic from the Thai medicinal herb Mitragyna speciosa

2004 · Kenjiro Matsumoto, Syunji Horie, et al. · Life Sciences · 228

Opioid receptors and legal highs:Salvia divinorumand Kratom

2008 · Kavita M. Babu, Christopher R. McCurdy, et al. · Clinical Toxicology · 221

Traditional and non-traditional uses of Mitragynine (Kratom): A survey of the literature

2016 · Darshan Singh, Suresh Narayanan, et al. · Brain Research Bulletin · 214

The pharmacology and toxicology of kratom: from traditional herb to drug of abuse

2015 · Marcus L. Warner, Nellie C. Kaufman, et al. · International Journal of Legal Medicine · 211

Unintentional Fatal Intoxications with Mitragynine and O-Desmethyltramadol from the Herbal Blend Krypton

2011 · R. Kronstrand, M. Roman, et al. · Journal of Analytical Toxicology · 198

“Legal highs” on the net—Evaluation of UK-based Websites, products and product information

2010 · Martin M. Schmidt, Akhilesh Sharma, et al. · Forensic Science International · 197

Central antinociceptive effects of mitragynine in mice: contribution of descending noradrenergic and serotonergic systems

1996 · Kinzo Matsumoto, Maho Mizowaki, et al. · European Journal of Pharmacology · 195

Kratom—Pharmacology, Clinical Implications, and Outlook: A Comprehensive Review

2020 · Steven C. Eastlack, Elyse M. Cornett, et al. · Pain and Therapy · 190

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Mitragyna speciosa, A Psychoactive Tree from Southeast Asia with Opioid Activity

2011 · Jessica E. Adkins, Edward W. Boyer, et al. · Current Topics in Medicinal Chemistry · 189

Ethnopharmacology of kratom and the Mitragyna alkaloids

1988 · Karl L.R. Jansen, Colin J. Prast · Journal of Ethnopharmacology · 186

Works count: 2,743

Citation count: 33,980