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Keyword

lapachol

Description: A naturally occurring naphthoquinone compound studied for its chemical properties and biological effects, including activity in disease and plant contexts.
Wikidata ID: wiki/Q739601
OpenAlex ID: keywords/lapachol
A general mechanism for microsomal activation of quinone anticancer agents to free radicals.
1978 · N R Bachur, S L Gordon, et al. · PubMed · 639
Antimalarial activity of phenazines from lapachol, β-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo
2004 · Valter F de Andrade-Neto, Marı́lia O.F Goulart, et al. · Bioorganic & Medicinal Chemistry Letters · 314
Lapachol: An overview
2007 · Hidayat Hussain, Karsten Krohn, et al. · ARKIVOC · 237
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Coevolutionary Patterns in Central American Bignoniaceae
1974 · Alwyn H. Gentry · Annals of the Missouri Botanical Garden · 235
The Trypanocidal Activity of Naphthoquinones: A Review
2009 · Antônio Ventura Pinto, Solange Lisboa de Castro · Molecules · 219
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Cancer Therapy with ß-Lapachone
2002 · Arthur Pardee, You Li, et al. · Current Cancer Drug Targets · 215
Red Lapacho (Tabebuia impetiginosa)—A global ethnopharmacological commodity?
2008 · J. Rubén Gómez Castellanos, José M. Prieto, et al. · Journal of Ethnopharmacology · 182
Natural products as starting points for future anti-malarial therapies: going back to our roots?
2011 · Timothy NC Wells · Malaria Journal · 177
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Antibacterial activity of Tabebuia impetiginosa Martius ex DC (Taheebo) against Helicobacter pylori
2005 · Byeoung-Soo Park, Hyun-Kyung Lee, et al. · Journal of Ethnopharmacology · 168
Um panorama atual da química e da farmacologia de naftoquinonas, com ênfase na beta-lapachona e derivados
2003 · Milton N. da Silva, Vítor F. Ferreira, et al. · Química Nova · 154
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Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity
1974 · Yoshifumi Iwamoto, Inge L. Hansen, et al. · Biochemical and Biophysical Research Communications · 152
Antiplasmodial Activity of Naphthoquinones Related to Lapachol andβ-Lapachone
2005 · Elisa Pérez-Sacau, Ana Estévez-Braun, et al. · Chemistry & Biodiversity · 151
Comparison of Antibacterial and Antifungal Activities of Lapachol and β-Lapachone
1994 · Pascale Guiraud, Régine Steiman, et al. · Planta Medica · 147
Antiinflammatory action of lapachol
1990 · Edvaldo Rodrigues de Almeida, Alvaro Alves da Silva Filho, et al. · Journal of Ethnopharmacology · 145
Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity
2013 · Wolfgang Kandioller, Evelyn Balsano, et al. · Chemical Communications · 141
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1,4-Naphthoquinones as inducers of oxidative damage and stress signaling in HaCaT human keratinocytes
2010 · Viola Klaus, Tobias Hartmann, et al. · Archives of Biochemistry and Biophysics · 134
Trypanosoma cruzi: Activities of lapachol and α- and β-lapachone derivatives against epimastigote and trypomastigote forms
2007 · Cristian Salas, Ricardo A. Tapia, et al. · Bioorganic & Medicinal Chemistry · 131
In vitroandin vivoevaluation of the toxicity of 1,4-naphthoquinone and 1,2-naphthoquinone derivatives againstTrypanosoma cruzi
1978 · J. N. Lopes, F. S. Cruz, et al. · Annals of Tropical Medicine and Parasitology · 112
Natural and Synthetic Naphthoquinones Active Against Trypanosoma Cruzi: An Initial Step Towards New Drugs for Chagas Disease
2010 · Cristian O. Salas, Mario Faundez, et al. · Current Medicinal Chemistry · 111
Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth
2022 · Sheng Zhan, Li Lu, et al. · British Journal of Cancer · 110
Lapachol and its congeners as anticancer agents: a review
2013 · Francesco Epifano, Salvatore Genovese, et al. · Phytochemistry Reviews · 109
Taxonomic Revisions in the Polyphyletic Genus Tabebuia s. I. (Bignoniaceae)
2007 · Susan O. Grose, R. G. Olmstead · Systematic Botany · 108
Occupational allergic contact dermatitis caused by wood dusts
2001 · T. Estlander, R. Jolanki, et al. · Contact Dermatitis · 106
Recognition and Evaluation of Lapachol as an Antitumor Agent
1968 · K. V. RAO, T. J. Mcbride, et al. · The Mouseion at the JAXlibrary (Jackson Laboratory) · 105
In vitro andin vivo Leishmanicidal activity of 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone (lapachol)
2001 · Maria Jania Teixeira, Yacy M. de Almeida, et al. · Phytotherapy Research · 97
Works count: 900
Citation count: 14,580
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