Get started
Keyword

LAT1

Description: LAT1 is a gene and membrane transporter protein that mediates cellular uptake of large neutral amino acids, including in cancer research.
Wikidata ID: wiki/Q18032750
OpenAlex ID: keywords/lat1
Expression Cloning and Characterization of a Transporter for Large Neutral Amino Acids Activated by the Heavy Chain of 4F2 Antigen (CD98)
1998 · Yoshikatsu Kanai, Hiroko Segawa, et al. · Journal of Biological Chemistry · 1,109
Quantitative targeted absolute proteomics of human blood–brain barrier transporters and receptors
2011 · Yasuo Uchida, Sumio Ohtsuki, et al. · Journal of Neurochemistry · 881
Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines
2001 · Osamu Yanagida, Yoshikatsu Kanai, et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 746
The SLC3 and SLC7 families of amino acid transporters
2013 · Dimitrios Fotiadis, Yoshikatsu Kanai, et al. · Molecular Aspects of Medicine · 680
Amino acid transporters ASCT2 and LAT1 in cancer: Partners in crime?
2005 · Bryan C. Fuchs, Barrie P. Bode · Seminars in Cancer Biology · 680
Identification and Functional Characterization of a Na+-independent Neutral Amino Acid Transporter with Broad Substrate Selectivity
1999 · Hiroko Segawa, Yoshiki Fukasawa, et al. · Journal of Biological Chemistry · 498
Selective expression of the large neutral amino acid transporter at the blood–brain barrier
1999 · Ruben J. Boado, Jian Yi Li, et al. · Proceedings of the National Academy of Sciences · 482
Transport of Amino Acid-Related Compounds Mediated by L-Type Amino Acid Transporter 1 (LAT1): Insights Into the Mechanisms of Substrate Recognition
2002 · Hiroshi Uchino, Yoshikatsu Kanai, et al. · Molecular Pharmacology · 421
LAT2, a New Basolateral 4F2hc/CD98-associated Amino Acid Transporter of Kidney and Intestine
1999 · Grégoire Rossier, Christian Meier, et al. · Journal of Biological Chemistry · 365
PDF
Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex
2019 · Renhong Yan, Xin Zhao, et al. · Nature · 358
Function and structure of heterodimeric amino acid transporters
2001 · Carsten A. Wagner, Florian Lang, et al. · American Journal of Physiology-Cell Physiology · 358
4F2 (CD98) Heavy Chain Is Associated Covalently with an Amino Acid Transporter and Controls Intracellular Trafficking and Membrane Topology of 4F2 Heterodimer
1999 · Eijiro Nakamura, Masaki Sato, et al. · Journal of Biological Chemistry · 339
Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2
2008 · Eva M. del Amo, Arto Urtti, et al. · European Journal of Pharmaceutical Sciences · 319
Activation of system L heterodimeric amino acid exchangers by intracellular substrates
2002 · Christian Meier, Zorica Ristic, et al. · The EMBO Journal · 314
The 4F2hc/LAT1 complex transports l-DOPA across the blood–brain barrier
2000 · Takashi Kageyama, Masaru Nakamura, et al. · Brain Research · 298
Leucine and mTORC1: a complex relationship
2012 · Kayleigh M. Dodd, Andrew R. Tee · American Journal of Physiology-Endocrinology and Metabolism · 293
System L: heteromeric exchangers of large, neutral amino acids involved in directional transport
2003 · François Verrey · Pflügers Archiv - European Journal of Physiology · 284
Amino acid transporter LAT1 (SLC7A5) as a molecular target for cancer diagnosis and therapeutics
2021 · Yoshikatsu Kanai · Pharmacology & Therapeutics · 283
The Human SLC7A5 (LAT1): The Intriguing Histidine/Large Neutral Amino Acid Transporter and Its Relevance to Human Health
2018 · Mariafrancesca Scalise, Michele Galluccio, et al. · Frontiers in Chemistry · 281
PDF
L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.
2015 · Qian Wang, Jeff Holst · PubMed · 274
l ‐Type amino acid transporter 1 inhibitors inhibit tumor cell growth
2009 · Koji Oda, Noriko Hosoda, et al. · Cancer Science · 274
PDF
Amino acid transport of y+L‐type by heterodimers of 4F2hc/CD98 and members of the glycoprotein‐associated amino acid transporter family
1999 · Rahel Pfeiffer, Grégoire Rossier, et al. · The EMBO Journal · 272
Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses
2015 · Martin Kolev, Sarah Dimeloe, et al. · Immunity · 256
PDF
Human LAT1, a Subunit of System L Amino Acid Transporter: Molecular Cloning and Transport Function
1999 · Puttur D. Prasad, Haiping Wang, et al. · Biochemical and Biophysical Research Communications · 254
Deletion of Amino Acid Transporter ASCT2 (SLC1A5) Reveals an Essential Role for Transporters SNAT1 (SLC38A1) and SNAT2 (SLC38A2) to Sustain Glutaminolysis in Cancer Cells
2016 · Angelika Bröer, Farid Rahimi, et al. · Journal of Biological Chemistry · 252
PDF
Works count: 2,068
Citation count: 49,850
Year
Topic
Type