Keyword

LC3

Description: A family of proteins involved in autophagy that associate with autophagosomes and are commonly studied as indicators of autophagic activity.

Primary topic: Autophagy in Disease and Therapy (37%)

Wikidata ID: wiki/Q18047661

OpenAlex ID: keywords/lc3

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2000 · Yukiko Kabeya, Noboru Mizushima, et al. · The EMBO Journal · 6,597

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Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

2017 · Changmeng Cui, Jianzhong Cui, et al. · Cellular Physiology and Biochemistry · 5,203

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

2007 · Serhiy Pankiv, Terje Høyvarde Clausen, et al. · Journal of Biological Chemistry · 4,574

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

2005 · Geir Bjørkøy, Trond Lamark, et al. · The Journal of Cell Biology · 3,272

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

2015 · Michael Lazarou, Danielle A. Sliter, et al. · Nature · 2,762

How to Interpret LC3 Immunoblotting

2007 · Noboru Mizushima, Tamotsu Yoshimori · Autophagy · 2,597

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In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

2003 · Noboru Mizushima, Akitsugu Yamamoto, et al. · Molecular Biology of the Cell · 2,322

Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

2004 · Maximiliano G. Gutierrez, Sharon S. Master, et al. · Cell · 2,246

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Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

2007 · Masaaki Komatsu, Satoshi Waguri, et al. · Cell · 2,125

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

2007 · Cristina Mammucari, Giulia Milan, et al. · Cell Metabolism · 1,950

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Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

2006 · Maiko Ogata, Shin-ichiro Hino, et al. · Molecular and Cellular Biology · 1,832

LC3 and Autophagy

2008 · Isei Tanida, Takashi Ueno, et al. · Methods in molecular biology · 1,783

Selective autophagy mediated by autophagic adapter proteins

2011 · Terje Johansen, Trond Lamark · Autophagy · 1,731

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Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

2012 · Lei Liu, Du Feng, et al. · Nature Cell Biology · 1,687

Network organization of the human autophagy system

2010 · Christian Behrends, Mathew E. Sowa, et al. · Nature · 1,553

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

2010 · Dale W. Hailey, Angelika S. Rambold, et al. · Cell · 1,429

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LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

2004 · Yukiko Kabeya, Noboru Mizushima, et al. · Journal of Cell Science · 1,392

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

2001 · Noboru Mizushima, Akitsugu Yamamoto, et al. · The Journal of Cell Biology · 1,359

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

2007 · Miguel A. Sanjuan, Christopher P. Dillon, et al. · Nature · 1,345

Nix is a selective autophagy receptor for mitochondrial clearance

2009 · Ivana Novak, Vladimir Kirkin, et al. · EMBO Reports · 1,307

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Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells

2013 · Charleen T. Chu, Jing Ji, et al. · Nature Cell Biology · 1,078

Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells

2004 · T Kanzawa, I M Germano, et al. · Cell Death and Differentiation · 986

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

2009 · Ruben K. Dagda, Salvatore J. Cherra, et al. · Journal of Biological Chemistry · 951

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Regulation of endoplasmic reticulum turnover by selective autophagy

2015 · Aliaksandr Khaminets, Theresa Heinrich, et al. · Nature · 946

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

2006 · Y Kouroku, E Fujita, et al. · Cell Death and Differentiation · 932

Works count: 11,920

Citation count: 363,500