Keyword

LDHA

Description: A human protein-coding gene that encodes lactate dehydrogenase A, an enzyme involved in cellular energy metabolism and lactate production.

Primary topic: Cancer, Hypoxia, and Metabolism (32%)

Wikidata ID: wiki/Q18028499

OpenAlex ID: keywords/ldha

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells

2016 · Almut Brand, Katrin Singer, et al. · Cell Metabolism · 2,032

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Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

1994 · G.L. Semenza, P.H. Roth, et al. · Journal of Biological Chemistry · 1,899

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Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

1996 · Gregg L. Semenza, Bing-Hua Jiang, et al. · Journal of Biological Chemistry · 1,752

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Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance

2006 · Valeria R. Fantin, Julie St-Pierre, et al. · Cancer Cell · 1,631

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Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

2010 · Anne Le, Charles R. Cooper, et al. · Proceedings of the National Academy of Sciences · 1,518

Targeting lactate metabolism for cancer therapeutics

2013 · Joanne R. Doherty, John L. Cleveland · Journal of Clinical Investigation · 1,167

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Genetic Analysis with Man–Mouse Somatic Cell Hybrids: Linkage between Human Lactate Dehydrogenase B and Peptidase B Genes

1970 · A. SILVANA SANTACHIARA, M. NABHOLZ, et al. · Nature · 1,128

c-Myc transactivation of LDH-A : Implications for tumor metabolism and growth

1997 · Hyunsuk Shim, Christine Dolde, et al. · Proceedings of the National Academy of Sciences · 1,093

Targeting cellular metabolism to improve cancer therapeutics

2013 · Y Zhao, E B Butler, et al. · Cell Death and Disease · 992

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MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

2009 · Chi V. Dang, Anne Le, et al. · Clinical Cancer Research · 946

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

2012 · Weiwei Yang, Yanhua Zheng, et al. · Nature Cell Biology · 918

Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc

2000 · Rebecca C. Osthus, Hyunsuk Shim, et al. · Journal of Biological Chemistry · 881

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Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

2013 · Zaheed Husain, Yannu Huang, et al. · The Journal of Immunology · 824

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

2016 · Min Peng, Na Yin, et al. · Science · 786

Lactate dehydrogenase A: A key player in carcinogenesis and potential target in cancer therapy

2018 · Yangbo Feng, Yanlu Xiong, et al. · Cancer Medicine · 706

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Multifaceted roles of glycolytic enzymes

2005 · Jung-whan Kim, Chi V. Dang · Trends in Biochemical Sciences · 683

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

2016 · Xinde Zheng, Leah Boyer, et al. · eLife · 668

Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

2019 · Weina Zhang, Guihua Wang, et al. · Cell · 602

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NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance

2024 · Hengxing Chen, Yun Li, et al. · Nature · 589

Correction: Corrigendum: Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells by facilitating LDHA phosphorylation

2017 · Yapeng Ji, Chuanzhen Yang, et al. · Nature Communications · 584

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Hypoxic Regulation of Lactate Dehydrogenase A

1995 · John D. Firth, Benjamin L. Ebert, et al. · Journal of Biological Chemistry · 576

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The Regulation and Function of Lactate Dehydrogenase A: Therapeutic Potential in Brain Tumor

2015 · Cara J. Valvona, Helen L. Fillmore, et al. · Brain Pathology · 568

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Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 · Jean-Christophe Jonas, Arun Sharma, et al. · Journal of Biological Chemistry · 559

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Pyruvate into lactate and back: From the Warburg effect to symbiotic energy fuel exchange in cancer cells

2009 · Olivier Feron · Radiotherapy and Oncology · 558

Lactic Dehydrogenases: Functions of the Two Types

1964 · David M. Dawson, Theodore L. Goodfriend, et al. · Science · 550

Works count: 4,488

Citation count: 118,100