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Keyword

LEF1

Description: LEF1 is a human protein-coding gene encoding a transcription factor involved in Wnt signaling, cell development, and gene regulation.
Wikidata ID: wiki/Q18040068
OpenAlex ID: keywords/lef1
Functional interaction of β-catenin with the transcription factor LEF-1
1996 · Jürgen Behrens, Jens P. von Kries, et al. · Nature · 2,914
The cyclin D1 gene is a target of the β-catenin/LEF-1 pathway
1999 · Michael Shtutman, Jacob Zhurinsky, et al. · Proceedings of the National Academy of Sciences · 2,230
XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
1996 · Miranda Molenaar, Marc van de Wetering, et al. · Cell · 1,825
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Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia
2007 · Charles G. Mullighan, Salil Goorha, et al. · Nature · 1,802
LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
2006 · Julia Skokowa, Gunnar Cario, et al. · Nature Medicine · 1,285
De Novo Hair Follicle Morphogenesis and Hair Tumors in Mice Expressing a Truncated β-Catenin in Skin
1998 · Uri Gat, Ramanuj DasGupta, et al. · Cell · 1,088
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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
1999 · Ramanuj DasGupta, Elaine Fuchs · Development · 1,000
Development of several organs that require inductive epithelial-mesenchymal interactions is impaired in LEF-1-deficient mice.
1994 · C van Genderen, R M Okamura, et al. · Genes & Development · 965
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Nuclear localization of β-catenin by interaction with transcription factor LEF-1
1996 · Otmar Huber, Reinhard Korn, et al. · Mechanisms of Development · 856
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Pax9 -deficient mice lack pharyngeal pouch derivatives and teeth and exhibit craniofacial and limb abnormalities
1998 · Heiko Peters, Annette Neubüser, et al. · Genes & Development · 833
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Sonic hedgehog regulates growth and morphogenesis of the tooth
2000 · Hélène R. Dassule, Paula Lewis, et al. · Development · 807
Nuclear signalling by tumour-associated antigen EpCAM
2009 · Dorothea Maetzel, Sabine Denzel, et al. · Nature Cell Biology · 720
The HMG domain of lymphoid enhancer factor 1 bends DNA and facilitates assembly of functional nucleoprotein structures
1992 · Klaus Giese, Jeffery Cox, et al. · Cell · 676
The metalloproteinase matrilysin is a target of β-catenin transactivation in intestinal tumors
1999 · Howard C Crawford, Barbara M Fingleton, et al. · Oncogene · 674
WNT/TCF Signaling through LEF1 and HOXB9 Mediates Lung Adenocarcinoma Metastasis
2009 · Don X. Nguyen, Anne C. Chiang, et al. · Cell · 614
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LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected]
1991 · A Travis, A Amsterdam, et al. · Genes & Development · 614
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A common human skin tumour is caused by activating mutations in β-catenin
1999 · Edward Chan, Uri Gat, et al. · Nature Genetics · 613
Structural basis for DNA bending by the architectural transcription factor LEF-1
1995 · John J. Love, Xiang Li, et al. · Nature · 573
Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin
2001 · Bradley J. Merrill, Uri Gat, et al. · Genes & Development · 558
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β-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
2005 · Danette L Daniels, William I Weis · Nature Structural & Molecular Biology · 551
Wnt/β-Catenin Signaling Promotes Renal Interstitial Fibrosis
2009 · Weichun He, Chunsun Dai, et al. · Journal of the American Society of Nephrology · 550
PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
2001 · Shrikesh Sachdev, Laurakay Bruhn, et al. · Genes & Development · 548
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Regulation of LEF-1/TCF transcription factors by Wnt and other signals
1999 · Quinn Eastman, Rudolf Grosschedl · Current Opinion in Cell Biology · 541
Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions.
1995 · K Giese, C Kingsley, et al. · Genes & Development · 541
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E-cadherin binding prevents β-catenin nuclear localization and β-catenin/LEF-1-mediated transactivation
1999 · Sandra Orsulic, Otmar Huber, et al. · Journal of Cell Science · 534
Works count: 2,935
Citation count: 112,500
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