Keyword

lethal factor

Description: Anthrax lethal factor is a zinc-dependent protease component of anthrax toxin that disrupts host-cell signaling.

Primary topic: Bacillus and Francisella bacterial research (58%)

Wikidata ID: wiki/Q4773866

OpenAlex ID: keywords/lethal-factor

Anthrax toxin edema factor: a bacterial adenylate cyclase that increases cyclic AMP concentrations of eukaryotic cells.

1982 · S H Leppla · Proceedings of the National Academy of Sciences · 935

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

2006 · Eric D Boyden, William F Dietrich · Nature Genetics · 861

Identification of the cellular receptor for anthrax toxin

2001 · Kenneth A. Bradley, Jeremy Mogridge, et al. · Nature · 843

Crystal structure of the anthrax toxin protective antigen

1997 · Carlo Petosa, R. John Collier, et al. · Nature · 755

Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

1986 · A M Friedlander · Journal of Biological Chemistry · 612

Anthrax Toxin: Receptor Binding, Internalization, Pore Formation, and Translocation

2007 · John A.T. Young, R. John Collier · Annual Review of Biochemistry · 601

Anthrax Toxin

2003 · R. John Collier, John A.T. Young · Annual Review of Cell and Developmental Biology · 511

Anthrax toxin protective antigen is activated by a cell surface protease with the sequence specificity and catalytic properties of furin.

1992 · K R Klimpel, S S Molloy, et al. · Proceedings of the National Academy of Sciences · 454

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

2008 · Susan L. Fink, Tessa Bergsbaken, et al. · Proceedings of the National Academy of Sciences · 403

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Binary Bacterial Toxins: Biochemistry, Biology, and Applications of CommonClostridiumandBacillusProteins

2004 · Holger Barth, Klaus Aktories, et al. · Microbiology and Molecular Biology Reviews · 399

Anthrax protective antigen forms oligomers during intoxication of mammalian cells.

1994 · J.C. Milne, D. Furlong, et al. · Journal of Biological Chemistry · 395

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Bacillus anthracis produces membrane-derived vesicles containing biologically active toxins

2010 · Johanna Rivera, Radames J. B. Cordero, et al. · Proceedings of the National Academy of Sciences · 385

Contribution of individual toxin components to virulence of Bacillus anthracis

1991 · C Pezard, P Berche, et al. · Infection and Immunity · 368

Immunological concepts of vaccine adjuvant activity

2000 · Virgil EJC Schijns · Current Opinion in Immunology · 330

Evidence for plasmid-mediated toxin production in Bacillus anthracis

1983 · P Mikesell, B E Ivins, et al. · Infection and Immunity · 325

N-terminal degradation activates the NLRP1B inflammasome

2019 · Ashley J. Chui, Marian C. Okondo, et al. · Science · 298

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Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin

2003 · Anshu Agrawal, Jai Lingappa, et al. · Nature · 294

Gold nanoparticles-based protease assay

2006 · Cristian Guarise, Lucia Pasquato, et al. · Proceedings of the National Academy of Sciences · 284

Anthrax toxin: channel-forming activity of protective antigen in planar phospholipid bilayers.

1989 · R O Blaustein, T M Koehler, et al. · Proceedings of the National Academy of Sciences · 270

Anthrax Pathogenesis

2015 · Mahtab Moayeri, Stephen H. Leppla, et al. · Annual Review of Microbiology · 263

Atomic structure of anthrax protective antigen pore elucidates toxin translocation

2015 · Jiansen Jiang, Bradley L. Pentelute, et al. · Nature · 254

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Proteolytic activation of bacterial toxins by eukaryotic cells is performed by furin and by additional cellular proteases

1995 · V M Gordon, K R Klimpel, et al. · Infection and Immunity · 252

The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes

2009 · Alexander F. Kintzer, Katie L. Thoren, et al. · Journal of Molecular Biology · 243

Structure of heptameric protective antigen bound to an anthrax toxin receptor: A role for receptor in pH-dependent pore formation

2004 · D. Borden Lacy, Darran J. Wigelsworth, et al. · Proceedings of the National Academy of Sciences · 228

The role of antibodies to Bacillus anthracis and anthrax toxin components in inhibiting the early stages of infection by anthrax spores

2001 · Susan Welkos, Stephen Little, et al. · Microbiology · 220

Works count: 1,134

Citation count: 35,330