Keyword

lethal toxin

Description: A bacterial protein toxin, particularly one produced by Bacillus anthracis, that contributes to disease by disrupting host-cell signaling and immune responses.

Primary topic: Bacillus and Francisella bacterial research (53%)

OpenAlex ID: keywords/lethal-toxin

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

2006 · Eric D Boyden, William F Dietrich · Nature Genetics · 861

Toxigenic clostridia

1990 · C L Hatheway · Clinical Microbiology Reviews · 662

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Combination bacteriolytic therapy for the treatment of experimental tumors

2001 · Long H. Dang, Chetan Bettegowda, et al. · Proceedings of the National Academy of Sciences · 563

Contribution of individual toxin components to virulence of Bacillus anthracis

1991 · C Pezard, P Berche, et al. · Infection and Immunity · 368

The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4

2004 · Li-Chung Hsu, Jin Mo Park, et al. · Nature · 357

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Evidence for plasmid-mediated toxin production in Bacillus anthracis

1983 · P Mikesell, B E Ivins, et al. · Infection and Immunity · 325

Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators

2005 · Jin Mo Park, Florian R. Greten, et al. · Immunity · 320

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The genome sequence of Bacillus cereus ATCC 10987 reveals metabolic adaptations and a large plasmid related to Bacillus anthracis pXO1

2004 · D. A. Rasko · Nucleic Acids Research · 312

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On the role of macrophages in anthrax.

1993 · P C Hanna, D Acosta, et al. · Proceedings of the National Academy of Sciences · 301

Type VI secretion and anti-host effectors

2015 · Abderrahman Hachani, Thomas E Wood, et al. · Current Opinion in Microbiology · 269

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Anthrax Pathogenesis

2015 · Mahtab Moayeri, Stephen H. Leppla, et al. · Annual Review of Microbiology · 263

An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster

2004 · Johannes H. Bauer, Stephan Goupil, et al. · Proceedings of the National Academy of Sciences · 234

Quantitative Pathology of Inhalational Anthrax I: Quantitative Microscopic Findings

2001 · Lev M Grinberg, Faina A Abramova, et al. · Modern Pathology · 231

The Roles of Various Fractions of Pseudomonas aeruginosa in Its Pathogenesis: III. Identity of the Lethal Toxins Produced in Vitro and in Vivo

1966 · P. V. Liu · The Journal of Infectious Diseases · 226

Anthrax lethal and edema toxins in anthrax pathogenesis

2014 · Shihui Liu, Mahtab Moayeri, et al. · Trends in Microbiology · 217

Anthrolysin O and Other Gram-positive Cytolysins Are Toll-like Receptor 4 Agonists

2004 · Jin Mo Park, Vincent H. Ng, et al. · The Journal of Experimental Medicine · 212

Clostridium perfringens ε-toxin shows structural similarity to the pore-forming toxin aerolysin

2004 · Ambrose R Cole, Maryse Gibert, et al. · Nature Structural & Molecular Biology · 189

Bacillus anthracis Edema Toxin Causes Extensive Tissue Lesions and Rapid Lethality in Mice

2005 · Aaron M. Firoved, Georgina F. Miller, et al. · American Journal Of Pathology · 188

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Fate of germinated Bacillus anthracis spores in primary murine macrophages

2001 · Chantal Guidi‐Rontani, Martine Levy, et al. · Molecular Microbiology · 169

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The alveolar macrophage: the Trojan horse of Bacillus anthracis

2002 · Chantal Guidi-Rontani · Trends in Microbiology · 164

Production and characterization of monoclonal antibodies to the protective antigen component of Bacillus anthracis toxin

1988 · S F Little, S H Leppla, et al. · Infection and Immunity · 162

Anthrax toxins: a paradigm of bacterial immune suppression

2006 · Cosima T. Baldari, Fiorella Tonello, et al. · Trends in Immunology · 161

Lethal toxin of Bacillus anthracis causes apoptosis of macrophages

2002 · Serguei G Popov, Rafael Villasmil, et al. · Biochemical and Biophysical Research Communications · 149

Isolation and characterization of three lethal and hemolytic toxins from the sea anemone Actinia equina L.

1988 · Peter Maček, Drago Lebez · Toxicon · 148

Cutting Edge: Resistance to Bacillus anthracis Infection Mediated by a Lethal Toxin Sensitive Allele of Nalp1b/Nlrp1b

2009 · Jill K Terra, Christopher K Cote, et al. · The Journal of Immunology · 147

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Works count: 592

Citation count: 18,260