Keyword

leukemogenesis

Description: The biological processes through which leukemia develops, involving genetic changes and interactions among blood-forming cells and their environment.

Primary topic: Acute Myeloid Leukemia Research (37%)

OpenAlex ID: keywords/leukemogenesis

Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia

2007 · Charles G. Mullighan, Salil Goorha, et al. · Nature · 1,802

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

1985 · J. M. Adams, A. W. Harris, et al. · Nature · 1,779

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 · Emma Shtivelman, Batia Lifshitz, et al. · Nature · 1,611

Acute lymphoblastic leukaemia

2008 · Ching-Hon Pui, Leslie L Robison, et al. · The Lancet · 1,566

FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N 6 -Methyladenosine RNA Demethylase

2016 · Zejuan Li, Hengyou Weng, et al. · Cancer Cell · 1,511

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor α gene to a novel transcribed locus

1990 · Hugues de Thé, Christine Chomienne, et al. · Nature · 1,355

The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR

1991 · Hugues de Thé, Catherine Lavau, et al. · Cell · 1,343

The Biology of Chronic Myeloid Leukemia

1999 · Stefan Faderl, Moshe Talpaz, et al. · New England Journal of Medicine · 1,304

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

2008 · Steven J. Howe, Marc R. Mansour, et al. · Journal of Clinical Investigation · 1,288

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MLL translocations, histone modifications and leukaemia stem-cell development

2007 · Andrei V. Krivtsov, Scott A. Armstrong · Nature reviews. Cancer · 1,250

BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros

2008 · Charles G. Mullighan, Christopher B. Miller, et al. · Nature · 1,075

Acute lymphoblastic leukaemia

2013 · Hiroto Inaba, Mel Greaves, et al. · The Lancet · 1,074

Role of the histone deacetylase complex in acute promyelocytic leukaemia

1998 · Richard J. Lin, Laszlo Nagy, et al. · Nature · 1,062

Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia

2005 · Ruibao Ren · Nature reviews. Cancer · 1,057

Acute myeloid leukemia ontogeny is defined by distinct somatic mutations

2014 · R. Coleman Lindsley, Brenton G. Mar, et al. · Blood · 989

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METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A Modification

2017 · Hengyou Weng, Huilin Huang, et al. · Cell stem cell · 970

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Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity

2004 · Kristin J Hope, Liqing Jin, et al. · Nature Immunology · 968

Selective Killing of Mixed Lineage Leukemia Cells by a Potent Small-Molecule DOT1L Inhibitor

2011 · Scott R. Daigle, Edward J. Olhava, et al. · Cancer Cell · 923

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Role of TP53 mutations in the origin and evolution of therapy-related acute myeloid leukaemia

2014 · Terrence N. Wong, Giridharan Ramsingh, et al. · Nature · 891

Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update

2011 · Ching-Hon Pui, William L. Carroll, et al. · Journal of Clinical Oncology · 843

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 · Franklin H. Epstein, Razelle Kurzrock, et al. · New England Journal of Medicine · 838

Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation

2007 · Masao Matsuoka, Kuan-Teh Jeang · Nature reviews. Cancer · 829

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

2011 · Xiao-Jing Yan, Jie Xu, et al. · Nature Genetics · 813

hDOT1L Links Histone Methylation to Leukemogenesis

2005 · Yuki Okada, Qin Feng, et al. · Cell · 805

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A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein

1994 · Jacqueline A. Dyck, Gerd G. Maul, et al. · Cell · 785

Works count: 13,420

Citation count: 352,000