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Keyword

Lgr5

Description: A gene encoding a receptor involved in Wnt signaling and used as a marker of stem cells in biological and cancer research.
Wikidata ID: wiki/Q18033097
OpenAlex ID: keywords/lgr5
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 · Toshiro Sato, Robert G. Vries, et al. · Nature · 7,193
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 · Nick Barker, Johan H. van Es, et al. · Nature · 5,681
Crypt stem cells as the cells-of-origin of intestinal cancer
2008 · Nick Barker, Rachel A. Ridgway, et al. · Nature · 2,166
Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
2010 · Hugo J. Snippert, Laurens G. van der Flier, et al. · Cell · 1,949
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Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
2008 · Laurens G. van der Flier, Hans Clevers · Annual Review of Physiology · 1,874
Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver
2014 · Meritxell Huch, Helmuth Gehart, et al. · Cell · 1,617
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Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
2010 · Nick Barker, Meritxell Huch, et al. · Cell stem cell · 1,542
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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
2011 · Wim de Lau, Nick Barker, et al. · Nature · 1,272
A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable
2011 · Hua Tian, Brian Biehs, et al. · Nature · 1,205
Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
2013 · Toshiro Sato, Hans Clevers · Science · 1,171
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
2012 · Arnout G. Schepers, Hugo J. Snippert, et al. · Science · 1,073
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
2012 · Bon-Kyoung Koo, Maureen Spit, et al. · Nature · 999
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
2014 · Kyle W. McCracken, Emily M. Catá, et al. · Nature · 977
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
2008 · Viljar Jaks, Nick Barker, et al. · Nature Genetics · 967
The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
2011 · Anna Merlos-Suárez, Francisco M. Barriga, et al. · Cell stem cell · 935
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Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche
2009 · Akifumi Ootani, Xingnan Li, et al. · Nature Medicine · 905
Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs
2011 · Thordur Oskarsson, Swarnali Acharyya, et al. · Nature Medicine · 869
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/β-catenin signaling
2011 · Kendra S. Carmon, Xing Gong, et al. · Proceedings of the National Academy of Sciences · 855
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
2016 · Semir Beyaz, Miyeko D. Mana, et al. · Nature · 847
The intestinal stem cell markers Bmi1 and Lgr5 identify two functionally distinct populations
2011 · Kelley S. Yan, Luis A. Chia, et al. · Proceedings of the National Academy of Sciences · 829
A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
2017 · Felipe de Sousa e Melo, Antonina V. Kurtova, et al. · Nature · 790
The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
2012 · Javier Muñoz, Daniel E Stange, et al. · The EMBO Journal · 772
Intestinal label-retaining cells are secretory precursors expressing Lgr5
2013 · Simon J. A. Buczacki, Heather Ireland Zecchini, et al. · Nature · 760
Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
2010 · Hugo J. Snippert, Andrea Haegebarth, et al. · Science · 752
Visualization and targeting of LGR5+ human colon cancer stem cells
2017 · Mariko Shimokawa, Yuki Ohta, et al. · Nature · 725
Works count: 3,570
Citation count: 121,800
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