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Keyword

loading dose

Description: A loading dose is an initial amount of medication given to rapidly achieve a desired concentration of a drug in the body.
Wikidata ID: wiki/Q6663385
OpenAlex ID: keywords/loading-dose
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
2020 · Xueting Yao, Fei Ye, et al. · Clinical Infectious Diseases · 2,663
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Evidence-Based Management of Anticoagulant Therapy
2012 · Anne Holbrook, Sam Schulman, et al. · CHEST Journal · 1,269
Randomized Double-Blind Assessment of the ONSET and OFFSET of the Antiplatelet Effects of Ticagrelor Versus Clopidogrel in Patients With Stable Coronary Artery Disease
2009 · Paul A. Gurbel, Kevin P. Bliden, et al. · Circulation · 1,160
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trial
2009 · Gilles Montalescot, Stephen D Wiviott, et al. · The Lancet · 1,068
Prasugrel Compared With High Loading- and Maintenance-Dose Clopidogrel in Patients With Planned Percutaneous Coronary Intervention
2007 · Stephen D. Wiviott, Dietmar Trenk, et al. · Circulation · 881
A Randomized Trial of Genotype-Guided Dosing of Warfarin
2013 · Munir Pirmohamed, Girvan Burnside, et al. · New England Journal of Medicine · 812
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Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary Syndromes
2010 · The CURRENT–OASIS 7 Investigators · New England Journal of Medicine · 768
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Pretreatment with Prasugrel in Non–ST-Segment Elevation Acute Coronary Syndromes
2013 · Gilles Montalescot, Leonardo Bolognese, et al. · New England Journal of Medicine · 657
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Rational Intravenous Doses of Theophylline
1973 · Paul A. Mitenko, Richard I. Ogilvie · New England Journal of Medicine · 647
Effects of Obesity on Pharmacokinetics
2000 · Georges Cheymol · Clinical Pharmacokinetics · 632
Absorption, Metabolization, and Antiplatelet Effects of 300-, 600-, and 900-mg Loading Doses of Clopidogrel
2005 · Nicolas von Beckerath, Dirk Taubert, et al. · Circulation · 623
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A comparison of prasugrel and clopidogrel loading doses on platelet function: magnitude of platelet inhibition is related to active metabolite formation
2006 · John T. Brandt, Christopher D. Payne, et al. · American Heart Journal · 572
Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
2006 · Tomas Jernberg, Christopher D. Payne, et al. · European Heart Journal · 538
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A Randomized Comparison of High Clopidogrel Loading Doses in Patients With Non–ST-Segment Elevation Acute Coronary Syndromes
2006 · Gilles Montalescot, Georges Sideris, et al. · Journal of the American College of Cardiology · 527
Double-Blind, Randomized Placebo Controlled Trial of Fulvestrant Compared With Exemestane After Prior Nonsteroidal Aromatase Inhibitor Therapy in Postmenopausal Women With Hormone Receptor–Positive, Advanced Breast Cancer: Results From EFECT
2008 · Stephen Chia, William Gradishar, et al. · Journal of Clinical Oncology · 515
Population Pharmacokinetic Analysis of Colistin Methanesulfonate and Colistin after Intravenous Administration in Critically Ill Patients with Infections Caused by Gram-Negative Bacteria
2009 · D. Plachouras, M. Karvanen, et al. · Antimicrobial Agents and Chemotherapy · 494
Inhibition of Platelet Aggregation by AZD6140, A Reversible Oral P2Y12Receptor Antagonist, Compared With Clopidogrel in Patients With Acute Coronary Syndromes
2007 · Robert F. Storey, Steen Husted, et al. · Journal of the American College of Cardiology · 483
Prasugrel achieves greater and faster P2Y12receptor-mediated platelet inhibition than clopidogrel due to more efficient generation of its active metabolite in aspirin-treated patients with coronary artery disease
2007 · L. Wallentin, C. Varenhorst, et al. · European Heart Journal · 457
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Comparison of Prasugrel and Ticagrelor Loading Doses in ST-Segment Elevation Myocardial Infarction Patients
2013 · Guido Parodi, Renato Valenti, et al. · Journal of the American College of Cardiology · 436
Population Pharmacokinetics of Intravenous Polymyxin B in Critically Ill Patients: Implications for Selection of Dosage Regimens
2013 · Ana M. Sandri, Cornelia B. Landersdorfer, et al. · Clinical Infectious Diseases · 431
Impact of P-glycoprotein on clopidogrel absorption
2006 · D TAUBERT, N VONBECKERATH, et al. · Clinical Pharmacology & Therapeutics · 422
Prehospital Use of Magnesium Sulfate as Neuroprotection in Acute Stroke
2015 · Jeffrey L. Saver, Sidney Starkman, et al. · New England Journal of Medicine · 407
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Randomized Assessment of Ticagrelor Versus Prasugrel Antiplatelet Effects in Patients with ST-Segment–Elevation Myocardial Infarction
2012 · Dimitrios Alexopoulos, Ioanna Xanthopoulou, et al. · Circulation Cardiovascular Interventions · 396
Efficacy, safety, and pharmacokinetics of emicizumab prophylaxis given every 4 weeks in people with haemophilia A (HAVEN 4): a multicentre, open-label, non-randomised phase 3 study
2019 · Steven W Pipe, Midori Shima, et al. · The Lancet Haematology · 392
The Relation of Dosing to Clopidogrel Responsiveness and the Incidence of High Post-Treatment Platelet Aggregation in Patients Undergoing Coronary Stenting
2005 · Paul A. Gurbel, Kevin P. Bliden, et al. · Journal of the American College of Cardiology · 381
Works count: 4,436
Citation count: 93,470
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