Keyword

LRP6

Description: LRP6 is a human protein-coding gene encoding a receptor involved in Wnt signaling and other cellular processes.

Primary topic: Wnt/β-catenin signaling in development and cancer (39%)

Wikidata ID: wiki/Q18028667

OpenAlex ID: keywords/lrp6

Sclerostin Binds to LRP5/6 and Antagonizes Canonical Wnt Signaling

2005 · Xiaofeng Li, Yazhou Zhang, et al. · Journal of Biological Chemistry · 1,365

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2000 · Keiko Tamai, Mikhail Semenov, et al. · Nature · 1,334

Proximal events in Wnt signal transduction

2009 · Stephane Angers, Randall T. Moon · Nature Reviews Molecular Cell Biology · 1,112

An LDL-receptor-related protein mediates Wnt signalling in mice

2000 · Kathleen I. Pinson, Jane Brennan, et al. · Nature · 1,086

2004 · Xi He, Mikhail Semenov, et al. · Development · 1,043

2001 · Bingyu Mao, Wei Wu, et al. · Nature · 1,041

Kremen proteins are Dickkopf receptors that regulate Wnt/β-catenin signalling

2002 · Bingyu Mao, Wei Wu, et al. · Nature · 1,037

Function and biological roles of the Dickkopf family of Wnt modulators

2006 · C Niehrs · Oncogene · 995

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

2012 · Huai-Xiang Hao, Yang Xie, et al. · Nature · 972

Wnt Induces LRP6 Signalosomes and Promotes Dishevelled-Dependent LRP6 Phosphorylation

2007 · Josipa Bilić, Ya-Lin Huang, et al. · Science · 935

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

2000 · Marcel Wehrli, Scott T. Dougan, et al. · Nature · 871

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

2005 · Xin Zeng, Keiko Tamai, et al. · Nature · 849

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

2001 · Anna Bafico, Guizhong Liu, et al. · Nature Cell Biology · 772

SOST Is a Ligand for LRP5/LRP6 and a Wnt Signaling Inhibitor

2005 · Mikhail Semënov, Keiko Tamai, et al. · Journal of Biological Chemistry · 769

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Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors

2003 · Silvia Maretto, Michelangelo Cordenonsi, et al. · Proceedings of the National Academy of Sciences · 761

Regulation of Wnt Signaling during Adipogenesis

2002 · Christina N. Bennett, Sarah E. Ross, et al. · Journal of Biological Chemistry · 743

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

2001 · Mikhail V Semënov, Keiko Tamai, et al. · Current Biology · 702

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LRP6 Mutation in a Family with Early Coronary Disease and Metabolic Risk Factors

2007 · Arya Mani, Arya Mani, et al. · Science · 590

Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

2005 · Gary Davidson, Wei Wu, et al. · Nature · 581

Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal

2007 · Luis C. Fuentealba, Edward Eivers, et al. · Cell · 554

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Functional Wnt Signaling Is Increased in Idiopathic Pulmonary Fibrosis

2008 · Melanie Königshoff, Nisha Balsara, et al. · PLoS ONE · 507

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Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

2010 · Luca Grumolato, Guizhong Liu, et al. · Genes & Development · 471

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Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia

2006 · Ji Li, Ildiko Sarosi, et al. · Bone · 441

A Novel Lung Metastasis Signature Links Wnt Signaling with Cancer Cell Self-Renewal and Epithelial-Mesenchymal Transition in Basal-like Breast Cancer

2009 · Theresa A. DiMeo, Kristen Anderson, et al. · Cancer Research · 415

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Canonical WNT signaling components in vascular development and barrier formation

2014 · Yulian Zhou, Yanshu Wang, et al. · Journal of Clinical Investigation · 350

Works count: 1,977

Citation count: 75,760