Keyword

macrolactonization

Description: A synthetic reaction that closes a molecular chain to form a macrocyclic lactone, used in the preparation of macrocyclic compounds.

Primary topic: Organic Chemistry Synthesis Methods (29%)

OpenAlex ID: keywords/macrolactonization

Macrolactonizations in the Total Synthesis of Natural Products

2006 · A. Parenty, X. Moreau, et al. · Chemical Reviews · 492

Proton-transfer steps in Steglich esterification: a very practical new method for macrolactonization

1985 · Eugene P. Boden, Gary E. Keck · The Journal of Organic Chemistry · 446

Scandium Trifluoromethanesulfonate as an Extremely Active Lewis Acid Catalyst in Acylation of Alcohols with Acid Anhydrides and Mixed Anhydrides

1996 · Kazuaki Ishihara, Manabu Kubota, et al. · The Journal of Organic Chemistry · 431

A novel and efficient macrolactonization of ω-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride (MNBA)

2002 · Isamu Shiina, Mari Kubota, et al. · Tetrahedron Letters · 275

Total Syntheses of Epothilones A and B

1997 · Dongfang Meng, Peter Bertinato, et al. · Journal of the American Chemical Society · 262

Macrolactonization via Hydrocarbon Oxidation

2006 · Kenneth J. Fraunhoffer, Prabagaran Narayanasamy, et al. · Journal of the American Chemical Society · 233

Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles

2013 · Xufen Yu, Dianqing Sun · Molecules · 231

Update 1 of: Macrolactonizations in the Total Synthesis of Natural Products

2012 · A. Parenty, X. Moreau, et al. · Chemical Reviews · 216

Polyketide synthase and non-ribosomal peptide synthetase thioesterase selectivity: logic gate or a victim of fate?

2015 · Mark E. Horsman, Taylor P. A. Hari, et al. · Natural Product Reports · 204

Total Synthesis of the Callipeltoside Aglycon

2001 · Ian Paterson, Robert D. M. Davies, et al. · Angewandte Chemie International Edition · 202

Total Syntheses of Epothilones A and B via a Macrolactonization-Based Strategy

1997 · K. C. Nicolaou, S. Ninkovic, et al. · Journal of the American Chemical Society · 199

Callipeltoside A: Total Synthesis, Assignment of the Absolute and Relative Configuration, and Evaluation of Synthetic Analogues

2002 · Barry M. Trost, Janet L. Gunzner, et al. · Journal of the American Chemical Society · 198

Synthesis of erythronolide a via a very efficient macrolactonization under usual acylation conditions with the Yamaguchi reagent

1990 · Masataka Hikota, Youji Sakurai, et al. · Tetrahedron Letters · 159

Total Synthesis of Bryostatin 1

2010 · Gary E. Keck, Yam B. Poudel, et al. · Journal of the American Chemical Society · 156

Strategies and Tactics in Organic Synthesis

1993 · Thomas Lindberg · 154

Chiral synthesis of polyketide-derived natural products. 27. Stereoselective synthesis of erythronolide A via an extremely efficient macrolactonization by the modified Yamaguchi method

1990 · Masataka Hikota, Hitoshi Tone, et al. · The Journal of Organic Chemistry · 139

Leucascandrolide A: Synthesis and Related Studies

2003 · Alec Fettes, Erick M. Carreira · The Journal of Organic Chemistry · 131

Total Synthesis of (−)-Apicularen A

2004 · Qibin Su, James S. Panek · Journal of the American Chemical Society · 130

Atom economic macrolactonization and lactonization viaredox-neutral rhodium-catalyzed coupling of terminal alkynes with carboxylic acids

2011 · Alexandre Lumbroso, Nacim Abermil, et al. · Chemical Science · 129

Total Synthesis of (−)-Bafilomycin A1

2002 · Karl A. Scheidt, Thomas D. Bannister, et al. · Journal of the American Chemical Society · 124

Structural basis for macrolactonization by the pikromycin thioesterase

2006 · David L Akey, Jeffrey D Kittendorf, et al. · Nature Chemical Biology · 120

Insights into Radicicol Biosynthesis via Heterologous Synthesis of Intermediates and Analogs

2010 · Hui Zhou 周卉, Kangjian Qiao 乔康健, et al. · Journal of Biological Chemistry · 108

Ru-Catalyzed Alkene−Alkyne Coupling. Total Synthesis of Amphidinolide P

2005 · Barry M. Trost, Julien P. N. Papillon, et al. · Journal of the American Chemical Society · 108

Macrolactonization via Ti(IV)-Mediated Epoxy-Acid Coupling: A Total Synthesis of (−)-Dactylolide [and Zampanolide]

2003 · Thomas R. Hoye, Min Hu · Journal of the American Chemical Society · 107

Sequence-Controlled Polymers Through Entropy-Driven Ring-Opening Metathesis Polymerization: Theory, Molecular Weight Control, and Monomer Design

2019 · Jamie A. Nowalk, Cheng Fang, et al. · Journal of the American Chemical Society · 98

Works count: 604

Citation count: 15,280