Get started
Keyword

MCC950

Description: A small-molecule inhibitor of the NLRP3 inflammasome, studied in biomedical research for its effects on inflammation and related diseases.
Wikidata ID: wiki/Q27083691
OpenAlex ID: keywords/mcc950
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
2015 · Rebecca C Coll, Avril A B Robertson, et al. · Nature Medicine · 2,806
NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice
2017 · Auvro R. Mridha, Alexander Wree, et al. · Journal of Hepatology · 1,100
MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition
2019 · Rebecca C. Coll, James R. Hill, et al. · Nature Chemical Biology · 1,017
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice
2018 · Richard Gordon, Eduardo A. Albornoz, et al. · Science Translational Medicine · 889
Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation
2018 · Chunxia Yao, Tina Veleva, et al. · Circulation · 653
PDF
Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-β and cognitive function in APP/PS1 mice
2016 · C. Dempsey, A. Rubio Araiz, et al. · Brain Behavior and Immunity · 567
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
2021 · Pan Pan, Miaomiao Shen, et al. · Nature Communications · 501
PDF
Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo
2019 · Ilie-Cosmin Stancu, Niels Cremers, et al. · Acta Neuropathologica · 443
PDF
MCC950 closes the active conformation of NLRP3 to an inactive state
2019 · Ana Tapia-Abellán, Diego Angosto-Bazarra, et al. · Nature Chemical Biology · 439
Role for NLRP3 Inflammasome–mediated, IL-1β–Dependent Responses in Severe, Steroid-Resistant Asthma
2017 · Richard Y. Kim, James W. Pinkerton, et al. · American Journal of Respiratory and Critical Care Medicine · 435
Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy
2020 · Qisheng Lin, Shu Li, et al. · Autophagy · 391
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase‐4 and caspase‐5
2015 · Paul J. Baker, Dave Boucher, et al. · European Journal of Immunology · 366
PDF
NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis
2019 · Matthias Sendler, Cindy van den Brandt, et al. · Gastroenterology · 349
NLRP3 Inflammasome Inhibition by MCC950 Reduces Atherosclerotic Lesion Development in Apolipoprotein E–Deficient Mice—Brief Report
2017 · Thomas van der Heijden, Eva Kritikou, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 348
PDF
The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction
2016 · Gerardus P.J. van Hout, Lena Bosch, et al. · European Heart Journal · 332
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
2022 · Inga V. Hochheiser, Michael Pilsl, et al. · Nature · 314
PDF
MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice
2018 · Agampodi Promoda Perera, Ruchira Fernando, et al. · Scientific Reports · 296
PDF
NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis
2018 · C Guo, R Fu, et al. · Clinical & Experimental Immunology · 286
Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension
2018 · Shalini M Krishnan, Yeong H Ling, et al. · Cardiovascular Research · 281
PDF
Gut microbiota dysbiosis promotes age-related atrial fibrillation by lipopolysaccharide and glucose-induced activation of NLRP3-inflammasome
2021 · Yun Zhang, Song Zhang, et al. · Cardiovascular Research · 272
NLRP3 inflammasome mediates M1 macrophage polarization and IL‐1β production in inflammatory root resorption
2020 · Jie Zhang, Xinqiang Liu, et al. · Journal Of Clinical Periodontology · 272
NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia
2019 · Rebecca Ward, Weiguo Li, et al. · Pharmacological Research · 270
Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model
2019 · Wei He, Ting Long, et al. · Journal of Neuroinflammation · 254
PDF
Therapeutic potential of MCC950, a specific inhibitor of NLRP3 inflammasome
2022 · Hao Li, Yanling Guan, et al. · European Journal of Pharmacology · 253
The microglial NLRP3 inflammasome is activated by amyotrophic lateral sclerosis proteins
2019 · Vandana Deora, John D. Lee, et al. · Glia · 243
Works count: 1,458
Citation count: 43,480
Year
Topic
Type