Keyword

MD-2

Description: MD-2 is an immune-system protein encoded by LY96 that binds bacterial lipopolysaccharide and partners with Toll-like receptor 4 in innate immune signaling.

Primary topic: Immune Response and Inflammation (55%)

Wikidata ID: wiki/Q14914329

OpenAlex ID: keywords/md-2

LPS induction of gene expression in human monocytes

2001 · Mausumee Guha, Nigel Mackman · Cellular Signalling · 2,307

MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 · Rintaro Shimazu, Sachiko Akashi, et al. · The Journal of Experimental Medicine · 2,185

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Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock

2007 · Thomas Vogl, Klaus Tenbrock, et al. · Nature Medicine · 1,413

Signal transduction by the lipopolysaccharide receptor, Toll‐like receptor‐4

2004 · Eva M. Pålsson‐McDermott, Luke A. J. O'Neill · Immunology · 1,252

Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines

2002 · Kol A Zarember, Paul J Godowski · The Journal of Immunology · 1,250

Recognition of lipopolysaccharide pattern by TLR4 complexes

2013 · Beom Seok Park, Jie-Oh Lee · Experimental & Molecular Medicine · 1,237

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The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 · Yoshinori Okamura, Michiko Watari, et al. · Journal of Biological Chemistry · 1,216

Crystal Structure of the TLR4-MD-2 Complex with Bound Endotoxin Antagonist Eritoran

2007 · Ho Min Kim, Beom Seok Park, et al. · Cell · 1,178

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Bacterial lipopolysaccharides and innate immunity

2001 · C. Alexander, E.T. Rietschel · Journal of Endotoxin Research · 1,120

Essential role of MD-2 in LPS responsiveness and TLR4 distribution

2002 · Yoshinori Nagai, Sachiko Akashi, et al. · Nature Immunology · 1,020

LPS, TLR4 and infectious disease diversity

2004 · Samuel I. Miller, Robert K. Ernst, et al. · Nature Reviews Microbiology · 999

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

2001 · Ramunas M. Vabulas, Parviz Ahmad-Nejad, et al. · Journal of Biological Chemistry · 805

Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein

2008 · Aurelien Trompette, Senad Divanovic, et al. · Nature · 762

Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis

2007 · Chantal A. Rivera, Patrick Adegboyega, et al. · Journal of Hepatology · 693

Decreased Expression of Toll-Like Receptor-4 and MD-2 Correlates with Intestinal Epithelial Cell Protection Against Dysregulated Proinflammatory Gene Expression in Response to Bacterial Lipopolysaccharide

2001 · Maria T Abreu, Puja Vora, et al. · The Journal of Immunology · 680

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Toll–Like Receptor 4 Mediates Inflammatory Signaling by Bacterial Lipopolysaccharide in Human Hepatic Stellate Cells

2003 · Yong-Han Paik, Robert F. Schwabe, et al. · Hepatology · 650

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Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex

2001 · Jean da Silva Correia, Katrin Soldau, et al. · Journal of Biological Chemistry · 649

Lipoteichoic Acid (LTA) of Streptococcus pneumoniaeand Staphylococcus aureus Activates Immune Cells via Toll-like Receptor (TLR)-2, Lipopolysaccharide-binding Protein (LBP), and CD14, whereas TLR-4 and MD-2 Are Not Involved

2003 · Nicolas W.J. Schröder, Siegfried Morath, et al. · Journal of Biological Chemistry · 640

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Targeting Inflammation Driven by HMGB1

2020 · Huan Yang, Haichao Wang, et al. · Frontiers in Immunology · 637

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Cutting Edge: Direct Interaction of TLR4 with NAD(P)H Oxidase 4 Isozyme Is Essential for Lipopolysaccharide-Induced Production of Reactive Oxygen Species and Activation of NF-κB

2004 · Hye Sun Park, Hye Young Jung, et al. · The Journal of Immunology · 633

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Lipopolysaccharide signaling in endothelial cells

2005 · Shauna M Dauphinee, Aly Karsan · Laboratory Investigation · 616

Regulation of Toll-Like Receptors in Human Monocytes and Dendritic Cells

2001 · Alberto Visintin, Alessandra Mazzoni, et al. · The Journal of Immunology · 612

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TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

2010 · Naoko Matsunaga, Noboru Tsuchimori, et al. · Molecular Pharmacology · 594

Human Toll-like receptor 4 recognizes host-specific LPS modifications

2002 · Adeline M. Hajjar, Robert K. Ernst, et al. · Nature Immunology · 578

Evidence that opioids may have toll-like receptor 4 and MD-2 effects

2009 · Mark R. Hutchinson, Yingning Zhang, et al. · Brain Behavior and Immunity · 574

Works count: 1,840

Citation count: 92,190