Keyword

MDA5

Description: An intracellular RNA-sensing protein that detects viral infection and activates innate antiviral immune signaling in cells.

Primary topic: interferon and immune responses (47%)

Wikidata ID: wiki/Q18045582

OpenAlex ID: keywords/mda5

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 · Hiroki Kato, Osamu Takeuchi, et al. · Nature · 3,881

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 · Taro Kawai, Ken Takahashi, et al. · Nature Immunology · 2,560

5'-Triphosphate RNA Is the Ligand for RIG-I

2006 · Veit Hornung, Jana Ellegast, et al. · Science · 2,470

A diverse range of gene products are effectors of the type I interferon antiviral response

2011 · John W. Schoggins, Sam J. Wilson, et al. · Nature · 2,434

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 · Etienne Meylan, Joseph Curran, et al. · Nature · 2,399

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RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

2006 · Andreas Pichlmair, Oliver Schulz, et al. · Science · 2,210

Immune Signaling by RIG-I-like Receptors

2011 · Yueh-Ming Loo, Michael Gale · Immunity · 1,873

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Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 · Mitsutoshi Yoneyama, Mika Kikuchi, et al. · The Journal of Immunology · 1,690

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

2008 · Hiroki Kato, Osamu Takeuchi, et al. · The Journal of Experimental Medicine · 1,601

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

2015 · David Roulois, Helen Loo Yau, et al. · Cell · 1,515

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Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

2006 · Kenya Honda, Akinori Takaoka, et al. · Immunity · 1,395

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Biology of Zika Virus Infection in Human Skin Cells

2015 · Rodolphe Hamel, Ophélie Dejarnac, et al. · Journal of Virology · 1,209

Intracellular pattern recognition receptors in the host response

2006 · Etienne Meylan, Jürg Tschopp, et al. · Nature · 1,206

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

2006 · Leonid Gitlin, Winfried Barchet, et al. · Proceedings of the National Academy of Sciences · 1,170

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

2007 · Yueh-Ming Loo, Jamie Fornek, et al. · Journal of Virology · 1,071

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

2010 · Amy Strange, Chris C A Spencer, et al. · Nature Genetics · 1,048

The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN -β promoter

2004 · J. Andrejeva, K. S. Childs, et al. · Proceedings of the National Academy of Sciences · 992

Toll‐like Receptor and RIG‐1‐like Receptor Signaling

2008 · Taro Kawai, Shizuo Akira · Annals of the New York Academy of Sciences · 987

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

2015 · Brian J. Liddicoat, Robert Piskol, et al. · Science · 959

Rare Variants of IFIH1 , a Gene Implicated in Antiviral Responses, Protect Against Type 1 Diabetes

2009 · Sergey Nejentsev, Neil Walker, et al. · Science · 956

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

2009 · Vesela Gateva, Johanna K Sandling, et al. · Nature Genetics · 811

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

2011 · Roland Züst, Luisa Cervantes-Barragan, et al. · Nature Immunology · 808

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Signaling Pathways Downstream of Pattern-Recognition Receptors and Their Cross Talk

2007 · Myeong Sup Lee, Young-Joon Kim · Annual Review of Biochemistry · 756

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

2006 · Takeshi Saito, Reiko Hirai, et al. · Proceedings of the National Academy of Sciences · 746

LGP2 is a positive regulator of RIG-I– and MDA5-mediated antiviral responses

2010 · Takashi Satoh, Hiroki Kato, et al. · Proceedings of the National Academy of Sciences · 703

Works count: 3,919

Citation count: 154,100