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Keyword

MDM2

Description: MDM2 is a human gene encoding a regulatory protein involved in p53 control, studied in cancer biology, tumorigenesis, and molecular genetics.
Wikidata ID: wiki/Q18028978
OpenAlex ID: keywords/mdm2
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 · Lyubomir T. Vassilev, Binh T. Vu, et al. · Science · 4,649
Mdm2 promotes the rapid degradation of p53
1997 · Ygal Haupt, Ruth Maya, et al. · Nature · 4,508
Ferroptosis as a p53-mediated activity during tumour suppression
2015 · Le Jiang, Ning Kon, et al. · Nature · 3,385
Regulation of p53 stability by Mdm2
1997 · Michael H. G. Kubbutat, Stephen N. Jones, et al. · Nature · 3,315
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
1992 · Jamil Momand, Gerard P. Zambetti, et al. · Cell · 3,114
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
1996 · Paul H. Kussie, Svetlana Gorina, et al. · Science · 2,200
DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
1997 · Sheau-Yann Shieh, Masako Ikeda, et al. · Cell · 2,096
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The p53 pathway: positive and negative feedback loops
2005 · Sandra L Harris, Arnold J Levine · Oncogene · 1,966
Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
1997 · Reiko Honda, Hirofumi Tanaka, et al. · FEBS Letters · 1,950
Amplification of a gene encoding a p53-associated protein in human sarcomas
1992 · J. D. Oliner, K. W. Kinzler, et al. · Nature · 1,950
The p53-mdm-2 autoregulatory feedback loop.
1993 · X Wu, J H Bayle, et al. · Genes & Development · 1,798
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ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
1998 · Yanping Zhang, Yue Xiong, et al. · Cell · 1,627
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Modes of p53 Regulation
2009 · Jan-Philipp Kruse, Wei Gu · Cell · 1,608
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The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53
1998 · Jason Pomerantz, Nicole Schreiber-Agus, et al. · Cell · 1,522
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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
1993 · Jonathan D. Oliner, Jennifer A. Pietenpol, et al. · Nature · 1,452
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
1995 · Roberta Montes de Oca Luna, Daniel S. Wagner, et al. · Nature · 1,419
The p53 pathway
1999 · Carol Prives, Peter A. Hall · The Journal of Pathology · 1,307
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mdm2 expression is induced by wild type p53 activity.
1993 · Y. Barak, T. Juven, et al. · The EMBO Journal · 1,289
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas
2006 · Franck Toledo, Geoffrey M. Wahl · Nature reviews. Cancer · 1,286
DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2
2000 · Atsushi Hirao, Young-Yun Kong, et al. · Science · 1,285
Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
1995 · Stephen N. Jones, Amy E. Roe, et al. · Nature · 1,278
MDM2, MDMX and p53 in oncogenesis and cancer therapy
2013 · Mark Wade, Yao-Cheng Li, et al. · Nature reviews. Cancer · 1,271
The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo
2002 · Loning Fu, Helene Pelicano, et al. · Cell · 1,270
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A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans
2004 · Gareth L. Bond, Wenwei Hu, et al. · Cell · 1,264
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A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus
2001 · Lindsey D. Mayo, David B. Donner · Proceedings of the National Academy of Sciences · 1,228
Works count: 14,890
Citation count: 508,200
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