Keyword

MDR1

Description: A gene symbol for ABCB1, which encodes a membrane transporter involved in drug efflux and is studied in cancer and pharmacology.

Primary topic: Drug Transport and Resistance Mechanisms (49%)

Wikidata ID: wiki/Q412902

OpenAlex ID: keywords/mdr1

Whole–genome characterization of chemoresistant ovarian cancer

2015 · Ann-Marie Patch, Elizabeth L. Christie, et al. · Nature · 1,578

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 · A T Fojo, K Ueda, et al. · Proceedings of the National Academy of Sciences · 1,546

Structure of a bacterial multidrug ABC transporter

2006 · Roger J. P. Dawson, Kaspar P. Locher · Nature · 1,280

Chimerism of the Transplanted Heart

2002 · Federico Quaini, Konrad Urbanek, et al. · New England Journal of Medicine · 1,266

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P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs.

1996 · A H Schinkel, E Wagenaar, et al. · Journal of Clinical Investigation · 1,265

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Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A.

1995 · A H Schinkel, E Wagenaar, et al. · Journal of Clinical Investigation · 1,107

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

2000 · Joan S. Steffan, Aleksey Kazantsev, et al. · Proceedings of the National Academy of Sciences · 1,064

Identification of functionally variant MDR1 alleles among European Americans and African Americans

2001 · R Kim · Clinical Pharmacology & Therapeutics · 1,009

Polymorphisms in human MDR1 (P-glycoprotein): recent advances and clinical relevance

2004 · C Marzolini · Clinical Pharmacology & Therapeutics · 896

Nuclear Receptor Response Elements Mediate Induction of Intestinal MDR1 by Rifampin

2001 · Anke Geick, Michel Eichelbaum, et al. · Journal of Biological Chemistry · 848

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The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

2001 · Timothy W. Synold, Isabelle Dussault, et al. · Nature Medicine · 840

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

2012 · Jessica L. Bell, Kristin Wächter, et al. · Cellular and Molecular Life Sciences · 783

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Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 · I B Roninson, J E Chin, et al. · Proceedings of the National Academy of Sciences · 686

Human P-glycoprotein transports cyclosporin A and FK506.

1993 · T. Saeki, K. Ueda, et al. · Journal of Biological Chemistry · 684

Paclitaxel-resistant Human Ovarian Cancer Cells Have Mutant β-Tubulins That Exhibit Impaired Paclitaxel-driven Polymerization

1997 · Paraskevi Giannakakou, Dan L. Sackett, et al. · Journal of Biological Chemistry · 682

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*

1997 · Kenneth S. Lown, Robert R. Mayo, et al. · Clinical Pharmacology & Therapeutics · 680

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Human P-glycoprotein transports cortisol, aldosterone, and dexamethasone, but not progesterone.

1992 · K Ueda, N Okamura, et al. · Journal of Biological Chemistry · 673

Association of Multidrug Resistance in Epilepsy with a Polymorphism in the Drug-Transporter GeneABCB1

2003 · Asra Siddiqui, Reinhold Kerb, et al. · New England Journal of Medicine · 665

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Genetic polymorphisms of the CYP3A4, CYP3A5, and MDR-1 genes and pharmacokinetics of the calcineurin inhibitors cyclosporine and tacrolimus

2003 · D Hesselink · Clinical Pharmacology & Therapeutics · 655

Active transport of imatinib into and out of cells: implications for drug resistance

2004 · Julia Thomas, Lihui Wang, et al. · Blood · 643

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Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin

2008 · Olga Kovalchuk, Jody Filkowski, et al. · Molecular Cancer Therapeutics · 635

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Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study.

2004 · David W Haas, Heather J Ribaudo, et al. · PubMed · 626

Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunodeficiency virus

1997 · T C White · Antimicrobial Agents and Chemotherapy · 610

Discovery and evaluation of inhibitors of human sphingosine kinase.

2003 · Kevin J French, Randy S Schrecengost, et al. · PubMed · 598

Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines

2007 · Constanze Hilgendorf, Gustav Ahlin, et al. · Drug Metabolism and Disposition · 584

Works count: 8,348

Citation count: 240,200