Get started
Keyword

MeCP2

Description: A protein encoded by the MECP2 gene that regulates gene expression and is studied in epigenetics and human disease.
Wikidata ID: wiki/Q18028997
OpenAlex ID: keywords/mecp2
Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2
1999 · Ruthie E. Amir, Ignatia B. Van den Veyver, et al. · Nature Genetics · 4,984
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
1998 · Xinsheng Nan, Huck-Hui Ng, et al. · Nature · 3,434
Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription
1998 · Peter L. Jones, Gert Jan C. Veenstra, et al. · Nature Genetics · 2,731
The DNA methyltransferases of mammals
2000 · T. H. Bestor · Human Molecular Genetics · 2,043
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
1999 · Elizabeth E. Cameron, Kurtis E. Bachman, et al. · Nature Genetics · 1,857
Methylation-Induced Repression— Belts, Braces, and Chromatin
1999 · Adrian P Bird, Alan P Wolffe · Cell · 1,827
PDF
MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription
2008 · Maria Chahrour, Sung Yun Jung, et al. · Science · 1,819
One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering
2013 · Hui Yang, Haoyi Wang, et al. · Cell · 1,595
PDF
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
2001 · Jacky Guy, Brian Hendrich, et al. · Nature Genetics · 1,554
DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation
2003 · Keri Martinowich, Daisuke Hattori, et al. · Science · 1,405
Rett syndrome: Revised diagnostic criteria and nomenclature
2010 · Jeffrey L. Neul, Walter E. Kaufmann, et al. · Annals of Neurology · 1,397
Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNA
1992 · Joe D. Lewis, Richard R. Meehan, et al. · Cell · 1,370
Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins
1998 · Brian Hendrich, Adrian Bird · Molecular and Cellular Biology · 1,361
PDF
MeCP2 Is a Transcriptional Repressor with Abundant Binding Sites in Genomic Chromatin
1997 · Xinsheng Nan, F.Javier Campoy, et al. · Cell · 1,276
PDF
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
2001 · Richard Z. Chen, Schahram Akbarian, et al. · Nature Genetics · 1,273
The Story of Rett Syndrome: From Clinic to Neurobiology
2007 · Maria Chahrour, Huda Y. Zoghbi · Neuron · 1,265
PDF
Derepression of BDNF Transcription Involves Calcium-Dependent Phosphorylation of MeCP2
2003 · Wen G. Chen, Qiang Chang, et al. · Science · 1,232
Reversal of Neurological Defects in a Mouse Model of Rett Syndrome
2007 · Jacky Guy, Jian Gan, et al. · Science · 1,226
The Genetics of Autism
2004 · Rebecca Muhle, Stephanie V. Trentacoste, et al. · PEDIATRICS · 1,209
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
2010 · Hsiao-Tuan Chao, Hongmei Chen, et al. · Nature · 1,165
Dynamic DNA methylation programs persistent adverse effects of early-life stress
2009 · Chris Murgatroyd, Alexandre V Patchev, et al. · Nature Neuroscience · 1,164
The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation
2003 · François Fuks, Paul J. Hurd, et al. · Journal of Biological Chemistry · 994
DNA methyltransferase Dnmt1 associates with histone deacetylase activity
2000 · François Fuks, Wendy A. Burgers, et al. · Nature Genetics · 994
MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System
2012 · Marian Mellén, Pinar Ayata, et al. · Cell · 943
PDF
REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis
2005 · Nurit Ballas, Christopher Grunseich, et al. · Cell · 938
PDF
Works count: 5,542
Citation count: 220,100
Year
Topic
Type