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Keyword

medication optimization

Description: A healthcare approach to improving medication use so that treatments are appropriate, effective, safe, and aligned with patients’ needs.
OpenAlex ID: keywords/medication-optimization
Why 90% of clinical drug development fails and how to improve it?
2022 · Duxin Sun, Wei Gao, et al. · Acta Pharmaceutica Sinica B · 1,748
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Challenges of Antibacterial Discovery
2011 · Lynn L. Silver · Clinical Microbiology Reviews · 1,379
Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial
2017 · Rasha Al-Lamee, David Thompson, et al. · The Lancet · 1,027
Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery
2001 · Michael M. Hann, Andrew R. Leach, et al. · Journal of Chemical Information and Computer Sciences · 877
The influence of lipophilicity in drug discovery and design
2012 · John A Arnott, Sonia Lobo Planey · Expert Opinion on Drug Discovery · 873
Computer-Aided Drug Design Methods
2016 · Wenbo Yu, Alexander D. MacKerell · Methods in molecular biology · 594
Targeting RNA structures with small molecules
2022 · Jessica L. Childs-Disney, Xueyi Yang, et al. · Nature Reviews Drug Discovery · 590
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Residence Time of Receptor−Ligand Complexes and Its Effect on Biological Function
2008 · Peter J. Tummino, Robert A. Copeland · Biochemistry · 544
Preemptive Clinical Pharmacogenetics Implementation: Current Programs in Five US Medical Centers
2014 · Henry M. Dunnenberger, Kristine R. Crews, et al. · The Annual Review of Pharmacology and Toxicology · 512
Do enthalpy and entropy distinguish first in class from best in class?
2008 · Ernesto Freire · Drug Discovery Today · 491
GDC-0449—A potent inhibitor of the hedgehog pathway
2009 · Kirk D. Robarge, Shirley A. Brunton, et al. · Bioorganic & Medicinal Chemistry Letters · 386
Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
2002 · Ana Martinez, Ana Castro, et al. · Medicinal Research Reviews · 333
Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3
2022 · Inga V. Hochheiser, Michael Pilsl, et al. · Nature · 314
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Fluorine in Medicinal Chemistry
2015 · Steven Swallow · Progress in medicinal chemistry · 280
Challenges in Modern Drug Discovery: A Case Study of Boceprevir, an HCV Protease Inhibitor for the Treatment of Hepatitis C Virus Infection
2008 · F. George Njoroge, Kevin X. Chen, et al. · Accounts of Chemical Research · 266
Evaluation of a Pharmacist-Led Medication Assessment Used to Identify Prevalence of and Associations With Polypharmacy and Potentially Inappropriate Medication Use Among Ambulatory Senior Adults With Cancer
2015 · Ginah Nightingale, Emily Hajjar, et al. · Journal of Clinical Oncology · 264
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Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders
2014 · P. Jeffrey Conn, Craig W. Lindsley, et al. · Nature Reviews Drug Discovery · 260
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Effectiveness of medication review: a systematic review and meta-analysis of randomized controlled trials
2017 · Victor Johan Bernard Huiskes, David Marinus Burger, et al. · BMC Family Practice · 227
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Development and Validation of the Revised Patients’ Attitudes Towards Deprescribing (rPATD) Questionnaire: Versions for Older Adults and Caregivers
2016 · Emily Reeve, Lee-Fay Low, et al. · Drugs & Aging · 217
Identification of ( R )- N -((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1 H -indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas
2016 · Rishi G. Vaswani, Victor S. Gehling, et al. · Journal of Medicinal Chemistry · 216
The dynamics of drug-target interactions: drug-target residence time and its impact on efficacy and safety
2010 · Robert A Copeland · Expert Opinion on Drug Discovery · 209
Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014
2013 · Kurt G. Pike, Karine Malagu, et al. · Bioorganic & Medicinal Chemistry Letters · 207
The Stages of Drug Discovery and Development Process
2019 · Amol B Deore, Jayprabha R Dhumane, et al. · Asian Journal of Pharmaceutical Research and Development · 203
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Disease management programmes for older people with heart failure: crucial characteristics which improve post-discharge outcomes
2005 · Doris S.F. Yu, David R. Thompson, et al. · European Heart Journal · 195
Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy
2021 · Chihyuan Chuang, Scott Collibee, et al. · Journal of Medicinal Chemistry · 181
Works count: 3,861
Citation count: 36,470
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