Keyword

MELAS

Description: MELAS is a mitochondrial disorder, formally called mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes, that can affect multiple organ systems.

Primary topic: Mitochondrial Function and Pathology (62%)

Wikidata ID: wiki/Q2666433

OpenAlex ID: keywords/melas

A mutation in the tRNALeu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies

1990 · Yu-ichi Goto, Ikuya Nonaka, et al. · Nature · 2,077

Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: A distinctive clinical syndrome

1984 · Steven G. Pavlakis, Peter C. Phillips, et al. · Annals of Neurology · 1,198

MELAS syndrome: Clinical manifestations, pathogenesis, and treatment options

2015 · Ayman W. El-Hattab, Adekunle M. Adesina, et al. · Molecular Genetics and Metabolism · 611

MELAS: Clinical features, biochemistry, and molecular genetics

1992 · E. Ciafaloni, E. Ricci, et al. · Annals of Neurology · 500

MELAS mutation in mtDNA binding site for transcription termination factor causes defects in protein synthesis and in respiration but no change in levels of upstream and downstream mature transcripts.

1992 · A Chomyn, A Martinuzzi, et al. · Proceedings of the National Academy of Sciences · 490

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Defects in Mitochondrial Protein Synthesis and Respiratory Chain Activity Segregate with the tRNALeu(UUR) Mutation Associated with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes

1992 · M P King, Y Koga, et al. · Molecular and Cellular Biology · 458

Reversible decreases in N‐acetylaspartate after acute brain injury

1995 · Nicola De Stefano, Paul M. Matthews, et al. · Magnetic Resonance in Medicine · 438

Effects and Mechanisms of Taurine as a Therapeutic Agent

2018 · Stephen Schaffer, Ha Won Kim · Biomolecules & Therapeutics · 417

MELAS: An original case and clinical criteria for diagnosis

1992 · Michio Hirano, Enzo Ricci, et al. · Neuromuscular Disorders · 415

Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke‐like episodes (MELAS)

1992 · Y. Goto, S. Horai, et al. · Neurology · 395

Neuronal degeneration and mitochondrial dysfunction

2003 · Eric A. Schon, Giovanni Manfredi · Journal of Clinical Investigation · 393

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Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases

2002 · Takeo Suzuki, Takeo Suzuki, et al. · The EMBO Journal · 388

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Epidemiology of A3243G, the Mutation for Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes: Prevalence of the Mutation in an Adult Population

1998 · Kari Majamaa, Jukka S. Moilanen, et al. · The American Journal of Human Genetics · 386

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Molecular pathology of MELAS and MERRF. The relationship between mutation load and clinical phenotypes

1997 · P. Chinnery · Brain · 384

Editorial (Thematic Issue: Mitochondrial Biogenesis: Pharmacological Approaches)

2014 · Teresa Valero · Current Pharmaceutical Design · 367

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Topical Review: Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Strokelike Episodes (MELAS): Current Concepts

1994 · Michio Hirano, Steven G. Pavlakis · Journal of Child Neurology · 366

Dichloroacetate causes toxic neuropathy in MELAS

2006 · P. Kaufmann, K. Engelstad, et al. · Neurology · 365

A point mutation in the mitochondrial tRNALeu(UUR) gene in melas (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes)

1990 · Yoko Kobayashi, Mariko Y. Momoi, et al. · Biochemical and Biophysical Research Communications · 364

Mitochondrial Encephalopathy, Lactic Acidosis, and Strokelike Episodes

2008 · Douglas M. Sproule, Petra Kaufmann · Annals of the New York Academy of Sciences · 352

Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

2010 · Der-Fen Suen, Derek P. Narendra, et al. · Proceedings of the National Academy of Sciences · 338

A new mtDNA mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)

1991 · Yu-ichi Goto, Ikuya Nonaka, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 325

Cardiac Involvement in Mitochondrial Diseases

1995 · Ryuichiro Anan, Masanori Nakagawa, et al. · Circulation · 314

l -Arginine improves the symptoms of strokelike episodes in MELAS

2005 · Y. Koga, Y. Akita, et al. · Neurology · 312

MELAS: A nationwide prospective cohort study of 96 patients in Japan

2011 · Shuichi Yatsuga, Nataliya Povalko, et al. · Biochimica et Biophysica Acta (BBA) - General Subjects · 306

Mitochondrial angiopathy in cerebral blood vessels of mitochondrial eneephalomyopathy

1987 · E. Ohama, S. Ohara, et al. · Acta Neuropathologica · 297

Works count: 4,061

Citation count: 71,740