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Keyword

MERTK

Description: A human gene encoding Mer tyrosine kinase, a TAM-family receptor involved in cell signaling, apoptotic cell clearance, and disease research.
Wikidata ID: wiki/Q18035403
OpenAlex ID: keywords/mertk
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
2012 · Emmanuel L Gautier, Tal Shay, et al. · Nature Immunology · 1,971
Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways
2013 · Won-Suk Chung, Laura E. Clarke, et al. · Nature · 1,372
Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
2000 · P. M. D'Cruz · Human Molecular Genetics · 873
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
2020 · José A. Nicolás-Ávila, Ana V. Lechuga-Vieco, et al. · Cell · 761
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The TAM family: phosphatidylserine-sensing receptor tyrosine kinases gone awry in cancer
2014 · Douglas K. Graham, Deborah DeRyckere, et al. · Nature reviews. Cancer · 699
Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa
2000 · Andreas Gal, Yun Li, et al. · Nature Genetics · 679
Efficient Clearance of Early Apoptotic Cells by Human Macrophages Requires M2c Polarization and MerTK Induction
2012 · Gaetano Zizzo, Brendan A Hilliard, et al. · The Journal of Immunology · 646
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A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells
2011 · Kim J. Png, Nils Halberg, et al. · Nature · 531
TAM Receptor Signaling in Immune Homeostasis
2015 · Carla V. Rothlin, Eugenio A. Carrera-Silva, et al. · Annual Review of Immunology · 511
Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
2019 · Kayla V. Myers, Sarah R. Amend, et al. · Molecular Cancer · 471
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The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
2014 · Magdalena Paolino, Axel Choidas, et al. · Nature · 453
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Sleep Loss Promotes Astrocytic Phagocytosis and Microglial Activation in Mouse Cerebral Cortex
2017 · Michele Bellesi, Luisa de Vivo, et al. · Journal of Neuroscience · 415
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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP
2020 · Yi Zhou, Mingjian Fei, et al. · Immunity · 400
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Enhanced Efferocytosis of Apoptotic Cardiomyocytes Through Myeloid-Epithelial-Reproductive Tyrosine Kinase Links Acute Inflammation Resolution to Cardiac Repair After Infarction
2013 · Elaine Wan, Xin Yi Yeap, et al. · Circulation Research · 386
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Phagocytosis executes delayed neuronal death after focal brain ischemia
2013 · Jonas J. Neher, Julius V. Emmrich, et al. · Proceedings of the National Academy of Sciences · 352
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Phosphatidylserine recognition by phagocytes: a view to a kill
2006 · Yi Wu, Nitu Tibrewal, et al. · Trends in Cell Biology · 341
Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome
2020 · Irune Diaz-Aparicio, Iñaki Paris, et al. · Journal of Neuroscience · 332
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Loss of Synchronized Retinal Phagocytosis and Age-related Blindness in Mice Lacking αvβ5 Integrin
2004 · Emeline F. Nandrot, Yoonhee Kim, et al. · The Journal of Experimental Medicine · 318
Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)
2011 · Edward Thorp, Tomas Vaisar, et al. · Journal of Biological Chemistry · 296
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Correction of the retinal dystrophy phenotype of the RCS rat by viral gene transfer of Mertk
2001 · Douglas Vollrath, Wei Feng, et al. · Proceedings of the National Academy of Sciences · 290
Patients With Acute-on-Chronic Liver Failure Have Increased Numbers of Regulatory Immune Cells Expressing the Receptor Tyrosine Kinase MERTK
2014 · Christine Bernsmeier, Oltin T. Pop, et al. · Gastroenterology · 286
A role for Mer tyrosine kinase in αvβ5 integrin-mediated phagocytosis of apoptotic cells
2005 · Yi Wu, Sukhwinder Singh, et al. · Journal of Cell Science · 278
Zika Virus Infection in Mice Causes Panuveitis with Shedding of Virus in Tears
2016 · Jonathan J. Miner, Abdoulaye Sene, et al. · Cell Reports · 275
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TAM receptor function in the retinal pigment epithelium
2006 · Dipti Prasad, Carla Vanina Rothlin, et al. · Molecular and Cellular Neuroscience · 269
Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis
2019 · Bishuang Cai, Paola Dongiovanni, et al. · Cell Metabolism · 265
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Works count: 2,137
Citation count: 51,220
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