Keyword

Minnelide

Description: Minnelide is a water-soluble prodrug of triptolide investigated as an anticancer therapeutic in preclinical and clinical research.

Primary topic: Pancreatic and Hepatic Oncology Research (31%)

Wikidata ID: wiki/Q27252236

OpenAlex ID: keywords/minnelide

Triptolide and Its Derivatives as Cancer Therapies

2019 · Pawan Noel, Daniel D. Von Hoff, et al. · Trends in Pharmacological Sciences · 311

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

2012 · Rohit Chugh, Veena Sangwan, et al. · Science Translational Medicine · 268

Triptolide Induces the Expression of miR-142-3p: A Negative Regulator of Heat Shock Protein 70 and Pancreatic Cancer Cell Proliferation

2013 · Tiffany N. MacKenzie, Nameeta Mujumdar, et al. · Molecular Cancer Therapeutics · 135

Inactivation of Cancer-Associated-Fibroblasts Disrupts Oncogenic Signaling in Pancreatic Cancer Cells and Promotes Its Regression

2017 · Patricia Dauer, Xianda Zhao, et al. · Cancer Research · 115

Triptolide-induced Cell Death in Pancreatic Cancer Is Mediated by O-GlcNAc Modification of Transcription Factor Sp1

2013 · Sulagna Banerjee, Veena Sangwan, et al. · Journal of Biological Chemistry · 110

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Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer

2015 · Sulagna Banerjee, Shrey Modi, et al. · Clinical Cancer Research · 108

Inhibition of NF-kappa B pathway leads to deregulation of epithelial–mesenchymal transition and neural invasion in pancreatic cancer

2016 · Alice Nomura, Kaustav Majumder, et al. · Laboratory Investigation · 86

CD133+ Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide

2014 · Sulagna Banerjee, Alice Nomura, et al. · Clinical Cancer Research · 77

Triptolide abrogates growth of colon cancer and induces cell cycle arrest by inhibiting transcriptional activation of E2F

2015 · Amanda R Oliveira, Georg Beyer, et al. · Laboratory Investigation · 75

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Sorafenib and triptolide as combination therapy for hepatocellular carcinoma

2014 · Osama A. Alsaied, Veena Sangwan, et al. · Surgery · 70

miR-204 mediated loss of Myeloid cell leukemia-1 results in pancreatic cancer cell death

2013 · Zhiyu Chen, Veena Sangwan, et al. · Molecular Cancer · 65

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Minnelide reduces tumor burden in preclinical models of osteosarcoma

2013 · Sulagna Banerjee, Venugopal Thayanithy, et al. · Cancer Letters · 58

Therapeutic Targeting of Hypoxia-Inducible Factors in Cancer

2024 · Saba Musleh Ud Din, Spencer G. Streit, et al. · International Journal of Molecular Sciences · 57

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Minnelide, a novel drug for pancreatic and liver cancer

2015 · Sulagna Banerjee, Ashok Saluja · Pancreatology · 55

“Heat shock protein 70 in pancreatic diseases: Friend or foe”

2017 · Bhuwan Giri, Vrishketan Sethi, et al. · Journal of Surgical Oncology · 54

Minnelide: A Novel Therapeutic That Promotes Apoptosis in Non-Small Cell Lung Carcinoma In Vivo

2013 · Ilona Rousalova, Sulagna Banerjee, et al. · PLoS ONE · 48

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A phase II trial of the super-enhancer inhibitor Minnelide™ in advanced refractory adenosquamous carcinoma of the pancreas

2022 · Nebojsa Skorupan, Mehwish I Ahmad, et al. · Future Oncology · 44

Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer

2017 · Olivia McGinn, Vineet K. Gupta, et al. · Scientific Reports · 44

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Minnelide Overcomes Oxaliplatin Resistance by Downregulating the DNA Repair Pathway in Pancreatic Cancer

2015 · Shrey Modi, Devika Kir, et al. · Journal of Gastrointestinal Surgery · 40

Pre-clinical evaluation of Minnelide as a therapy for acute myeloid leukemia

2019 · Bhuwan Giri, Vineet K. Gupta, et al. · Journal of Translational Medicine · 37

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Targeting HSF1 disrupts HSP90 chaperone function in chronic lymphocytic leukemia

2015 · Siddhartha Ganguly, Trisha Home, et al. · Oncotarget · 37

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Minnelide/Triptolide Impairs Mitochondrial Function by Regulating SIRT3 in P53-Dependent Manner in Non-Small Cell Lung Cancer

2016 · Ajay Kumar, Catherine Corey, et al. · PLoS ONE · 34

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First-in-Human Phase I Study of Minnelide in Patients With Advanced Gastrointestinal Cancers: Safety, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity

2024 · Erkut Borazanci, Ashok Saluja, et al. · The Oncologist · 31

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Minnelide effectively eliminates CD133+ side population in pancreatic cancer

2015 · Alice Nomura, Olivia McGinn, et al. · Molecular Cancer · 31

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Triptolide and its prodrug minnelide suppress Hsp70 and inhibit in vivo growth in a xenograft model of mesothelioma

2015 · Blake A. Jacobson, Esther Z. Chen, et al. · Genes & Cancer · 31

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Works count: 175

Citation count: 2,484