Get started
Keyword

mPGES-1

Description: An inducible prostaglandin E synthase enzyme that produces prostaglandin E2 in inflammatory and other signaling pathways.
Wikidata ID: wiki/Q22676692
OpenAlex ID: keywords/mpges-1
Multifaceted roles of PGE2 in inflammation and cancer
2012 · Masako Nakanishi, Daniel W. Rosenberg · Seminars in Immunopathology · 593
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
2003 · Catherine E. Trebino, Jeffrey L. Stock, et al. · Proceedings of the National Academy of Sciences · 552
Membrane Prostaglandin E Synthase-1: A Novel Therapeutic Target
2007 · Bengt Samuelsson, Ralf Morgenstern, et al. · Pharmacological Reviews · 538
Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function
2006 · Y. Cheng · Journal of Clinical Investigation · 339
PDF
Microsomal prostaglandin E synthase-1 is the central switch during immune-induced pyresis
2003 · David Engblom, Sipra Saha, et al. · Nature Neuroscience · 310
Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1
2004 · Daisuke Kamei, Kiyofumi Yamakawa, et al. · Journal of Biological Chemistry · 279
PDF
Hyperplastic gastric tumors induced by activated macrophages in COX‐2/mPGES‐1 transgenic mice
2004 · Hiroko Oshima, Masanobu Oshima, et al. · The EMBO Journal · 251
PDF
Carcinogenesis in Mouse Stomach by Simultaneous Activation of the Wnt Signaling and Prostaglandin E2 Pathway
2006 · Hiroko Oshima, Akihiro Matsunaga, et al. · Gastroenterology · 241
Resveratrol potently reduces prostaglandin E2production and free radical formation in lipopolysaccharide-activated primary rat microglia
2007 · Eduardo Candelario-Jalil, Antonio C Pinheiro de Oliveira, et al. · Journal of Neuroinflammation · 223
PDF
HGF Mediates the Anti-inflammatory Effects of PRP on Injured Tendons
2013 · Jianying Zhang, Kellie K. Middleton, et al. · PLoS ONE · 213
PDF
Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages
2014 · François Coulombe, Joanna Jaworska, et al. · Immunity · 206
PDF
NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts
2010 · Antonio González-Sarrías, Mar Larrosa, et al. · British Journal Of Nutrition · 206
PDF
Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
2006 · Miao Wang, Alicia M. Zukas, et al. · Proceedings of the National Academy of Sciences · 205
Potential Role of Microsomal Prostaglandin E Synthase-1 in Tumorigenesis
2003 · Daisuke Kamei, Makoto Murakami, et al. · Journal of Biological Chemistry · 198
PDF
Postsynaptically Synthesized Prostaglandin E2 (PGE2) Modulates Hippocampal Synaptic Transmission via a Presynaptic PGE2 EP2 Receptor
2005 · Nan Sang, Jian Zhang, et al. · Journal of Neuroscience · 192
PDF
Glucosamine and chondroitin sulfate regulate gene expression and synthesis of nitric oxide and prostaglandin E2 in articular cartilage explants
2005 · P.S. Chan, J.P. Caron, et al. · Osteoarthritis and Cartilage · 184
Microsomal Prostaglandin E Synthase-1 Is a Major Terminal Synthase That Is Selectively Up-Regulated During Cyclooxygenase-2-Dependent Prostaglandin E2 Production in the Rat Adjuvant-Induced Arthritis Model
2003 · David Claveau, Mirna Sirinyan, et al. · The Journal of Immunology · 180
PDF
Genetic Deletion of mPGES-1 Suppresses Intestinal Tumorigenesis
2008 · Masako Nakanishi, David C. Montrose, et al. · Cancer Research · 167
Human Microsomal Prostaglandin E Synthase-1
2003 · Staffan Thorén, Rolf Weinander, et al. · Journal of Biological Chemistry · 167
PDF
Prostaglandin E Synthase, a Terminal Enzyme for Prostaglandin E2 Biosynthesis
2005 · Ichiro Kudo, Makoto Murakami · BMB Reports · 165
PDF
Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1
2008 · Andreas Koeberle, Ulf Siemoneit, et al. · Journal of Pharmacology and Experimental Therapeutics · 164
Pivotal Advance: Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells
2010 · Evgeniy Eruslanov, Irina Daurkin, et al. · Journal of Leukocyte Biology · 160
Prostaglandin E synthases: Understanding their pathophysiological roles through mouse genetic models
2010 · Shuntaro Hara, Daisuke Kamei, et al. · Biochimie · 156
MF63 [2-(6-Chloro-1 H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a Selective Microsomal Prostaglandin E Synthase-1 Inhibitor, Relieves Pyresis and Pain in Preclinical Models of Inflammation
2008 · Daigen Xu, Steven E. Rowland, et al. · Journal of Pharmacology and Experimental Therapeutics · 156
Structural basis for induced formation of the inflammatory mediator prostaglandin E 2
2008 · Caroline Jegerschöld, Sven-Christian Pawelzik, et al. · Proceedings of the National Academy of Sciences · 155
PDF
Works count: 1,697
Citation count: 35,160
Year
Topic
Type