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Keyword

MPTP

Description: MPTP is a neurotoxic chemical compound used in research as a model for Parkinsonian dopaminergic neuron damage.
Wikidata ID: wiki/Q239816
OpenAlex ID: keywords/mptp
Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis
1983 · J. William Langston, Philip Ballard, et al. · Science · 4,906
Frequency Dependence of Signal Power and Spatial Reach of the Local Field Potential
2013 · Leski, Szymon, Lindén, Henrik, et al. · PubMed · 3,639
Mitochondrial Complex I Deficiency in Parkinson's Disease
1990 · A. H. V. Schapira, J. M. Cooper, et al. · Journal of Neurochemistry · 2,283
Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators
2006 · Julie St-Pierre, Stavit Drori, et al. · Cell · 2,233
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A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.
1983 · R S Burns, C C Chiueh, et al. · Proceedings of the National Academy of Sciences · 2,149
The primate subthalamic nucleus. II. Neuronal activity in the MPTP model of parkinsonism
1994 · H. Bergman, T. Wichmann, et al. · Journal of Neurophysiology · 1,367
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
1988 · Etienne Hirsch, Ann M. Graybiel, et al. · Nature · 1,303
Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine
1985 · William J. Nicklas, Ivy Vyas, et al. · Life Sciences · 1,263
Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.
1985 · J A Javitch, R J D'Amato, et al. · Proceedings of the National Academy of Sciences · 1,263
Neurodegeneration Prevented by Lentiviral Vector Delivery of GDNF in Primate Models of Parkinson's Disease
2000 · Jeffrey H. Kordower, Marina E. Emborg, et al. · Science · 1,251
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease
2001 · David Blum, Sakina Torch, et al. · Progress in Neurobiology · 1,246
MONOAMINE OXIDASE: From Genes to Behavior
1999 · J. C. Shih, K. Chen, et al. · Annual Review of Neuroscience · 1,207
Parkinson's Disease
1998 · Anthony E. Lang, Andres M. Lozano · New England Journal of Medicine · 1,202
Protocol for the MPTP mouse model of Parkinson's disease
2007 · Vernice Jackson-Lewis, Serge Przedborski · Nature Protocols · 1,112
Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine
2000 · Peter Klivenyi, Ole A. Andreassen, et al. · Journal of Neuroscience · 1,110
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Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase
1984 · Kan Chiba, Anthony Trevor, et al. · Biochemical and Biophysical Research Communications · 1,097
Abnormalities of the electron transport chain in idiopathic parkinson's disease
1989 · William Davis Parker, Sally J. Boyson, et al. · Annals of Neurology · 1,063
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
1999 · Gabriel T. Liberatore, Vernice Jackson-Lewis, et al. · Nature Medicine · 1,046
Protection against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine by monoamine oxidase inhibitors
1984 · Richard E. Heikkila, Lawrence Manzino, et al. · Nature · 1,010
Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
1999 · J. W. Langston, L. S. Forno, et al. · Annals of Neurology · 976
Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey
1984 · J. William Langston, Lysia S. Forno, et al. · Brain Research · 922
Classic toxin-induced animal models of Parkinson?s disease: 6-OHDA and MPTP
2004 · Andreas Schober · Cell and Tissue Research · 803
Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism
1984 · S. P. Markey, J. N. Johannessen, et al. · Nature · 786
Oxidative stress and nitration in neurodegeneration: Cause, effect, or association?
2003 · Harry Ischiropoulos, Joseph S. Beckman · Journal of Clinical Investigation · 747
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Toxin-induced models of Parkinson’s disease
2005 · Jordi Bové, Delphine Prou, et al. · NeuroRx · 739
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Works count: 6,927
Citation count: 278,700
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