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Keyword

MRP2

Description: A membrane transporter encoded by ABCC2 that exports various compounds, including drug conjugates, and is studied in pharmacology and disease.
Wikidata ID: wiki/Q18973927
OpenAlex ID: keywords/mrp2
A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins
2000 · P. Borst, R. Evers, et al. · JNCI Journal of the National Cancer Institute · 1,751
Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense
2004 · Elaine M. Leslie, Roger G. Deeley, et al. · Toxicology and Applied Pharmacology · 1,406
Bile Salt Transporters: Molecular Characterization, Function, and Regulation
2003 · Michael Trauner, James L. Boyer · Physiological Reviews · 998
Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor
2002 · Heidi R. Kast, Bryan Goodwin, et al. · Journal of Biological Chemistry · 916
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Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.
1997 · M Kool, M de Haas, et al. · PubMed · 893
Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene
1996 · Coen C. Paulusma, Piter J. Bosma, et al. · Science · 822
Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance
1999 · Jörg König, Anne T. Nies, et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 791
Ursodeoxycholic acid in cholestatic liver disease: Mechanisms of action and therapeutic use revisited
2002 · Gustav Paumgartner, Ulrich Beuers · Hepatology · 749
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade
2015 · Zhaolin Chen, Tianlu Shi, et al. · Cancer Letters · 730
Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
2013 · Mitchell R. McGill, Hartmut Jaeschke · Pharmaceutical Research · 705
Drug Resistance and ATP-Dependent Conjugate Transport Mediated by the Apical Multidrug Resistance Protein, MRP2, Permanently Expressed in Human and Canine Cells
1999 · Yunhai Cui, Jörg König, et al. · Molecular Pharmacology · 676
Enterohepatic Circulation
2002 · Michael S. Roberts, Beatrice M. Magnusson, et al. · Clinical Pharmacokinetics · 664
The multidrug resistance protein family
1999 · Piet Borst, Raymond Evers, et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 648
Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.
1998 · R Evers, M Kool, et al. · Journal of Clinical Investigation · 620
A liver-on-a-chip platform with bioprinted hepatic spheroids
2016 · Nupura S Bhise, Vijayan Manoharan, et al. · Biofabrication · 612
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Genetic architecture of artemisinin-resistant Plasmodium falciparum
2015 · Olivo Miotto, Roberto Amato, et al. · Nature Genetics · 610
Bile Salt Transporters
2002 · Peter J. Meier, B. Stieger · Annual Review of Physiology · 586
Expression of Thirty-six Drug Transporter Genes in Human Intestine, Liver, Kidney, and Organotypic Cell Lines
2007 · Constanze Hilgendorf, Gustav Ahlin, et al. · Drug Metabolism and Disposition · 584
The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability
2003 · Lauretta M.S Chan, Simon Lowes, et al. · European Journal of Pharmaceutical Sciences · 583
Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver
2000 · Bruno Stieger, Karin Fattinger, et al. · Gastroenterology · 582
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Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells
2005 · Roohangiz Safaei, Barrett J. Larson, et al. · Molecular Cancer Therapeutics · 564
A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
1997 · C C Paulusma, M Kool, et al. · Hepatology · 553
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Characterization of the Human Multidrug Resistance Protein Isoform Mrp3 Localized to the Basolateral Hepatocyte Membrane
1999 · Jörg König, Daniel Rost, et al. · Hepatology · 504
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The MRP4/ABCC4 Gene Encodes a Novel Apical Organic Anion Transporter in Human Kidney Proximal Tubules
2002 · Rémon A. M. H. van Aubel, Pascal H. E. Smeets, et al. · Journal of the American Society of Nephrology · 501
The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis
1997 · M Trauner, M Arrese, et al. · Gastroenterology · 500
Works count: 5,854
Citation count: 196,300
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