Keyword

mTORC2

Description: mTORC2 is a protein signaling complex containing the mechanistic target of rapamycin and Rictor, involved in cellular growth and metabolism.

Primary topic: PI3K/AKT/mTOR signaling in cancer (45%)

Wikidata ID: wiki/Q14876061

OpenAlex ID: keywords/mtorc2

mTOR: from growth signal integration to cancer, diabetes and ageing

2010 · Roberto Zoncu, Alejo Efeyan, et al. · Nature Reviews Molecular Cell Biology · 3,933

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 · Dos D. Sarbassov, Siraj M. Ali, et al. · Molecular Cell · 2,656

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mTOR signaling at a glance

2009 · Mathieu Laplante, David M. Sabatini · Journal of Cell Science · 2,175

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 · Estela Jacinto, Robbie Loewith, et al. · Nature Cell Biology · 2,114

Acute Skeletal Muscle Wasting in Critical Illness

2013 · Zudin A. Puthucheary, Jaikitry Rawal, et al. · JAMA · 2,101

mTOR Signaling in Growth, Metabolism, and Disease

2017 · Robert A. Saxton, David M. Sabatini · Cell · 2,074

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An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

2009 · Carson C. Thoreen, Seong A. Kang, et al. · Journal of Biological Chemistry · 1,796

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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 · David A. Guertin, Deanna M. Stevens, et al. · Developmental Cell · 1,415

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mTOR and cancer: insights into a complex relationship

2006 · David M. Sabatini · Nature reviews. Cancer · 1,322

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

2009 · Timothy R. Peterson, Mathieu Laplante, et al. · Cell · 1,205

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

2012 · Dudley W. Lamming, Lan Ye, et al. · Science · 1,196

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mTOR signaling: At the crossroads of plasticity, memory and disease

2009 · Charles A. Hoeffer, Eric Klann · Trends in Neurosciences · 1,127

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

2011 · Greg M Delgoffe, Kristen N Pollizzi, et al. · Nature Immunology · 1,111

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The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

2011 · Peggy P. Hsu, Seong A. Kang, et al. · Science · 1,082

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Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

2009 · Morris E Feldman, Beth Apsel, et al. · PLoS Biology · 1,082

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mTOR as a central hub of nutrient signalling and cell growth

2018 · Joungmok Kim, Kun-Liang Guan · Nature Cell Biology · 1,074

Multifaceted role of mTOR (mammalian target of rapamycin) signaling pathway in human health and disease

2023 · Vivek Panwar, Aishwarya Singh, et al. · Signal Transduction and Targeted Therapy · 954

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

2008 · Juan M. García-Martínez, Dario R. Alessi · Biochemical Journal · 905

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Targeting mTOR for cancer therapy

2019 · Hui Hua, Qingbin Kong, et al. · Journal of Hematology & Oncology · 900

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

2011 · Yonghao Yu, Sang-Oh Yoon, et al. · Science · 854

The mTOR Signalling Pathway in Human Cancer

2012 · Helena Pópulo, José Manuel Lopes, et al. · International Journal of Molecular Sciences · 826

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Regulation and metabolic functions of mTORC1 and mTORC2

2021 · Angelia Szwed, Eugene Kim, et al. · Physiological Reviews · 814

AMPK and mTOR in Cellular Energy Homeostasis and Drug Targets

2011 · Ken Inoki, Joungmok Kim, et al. · The Annual Review of Pharmacology and Toxicology · 795

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

2009 · Christine M. Chresta, Barry R. Davies, et al. · Cancer Research · 793

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

2013 · Hu Zeng, Kai Yang, et al. · Nature · 788

Works count: 4,462

Citation count: 172,800