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Keyword

mutational signatures

Description: Characteristic patterns of mutation types in genomic sequences that can indicate the biological processes responsible for DNA damage and mutation.
Wikidata ID: wiki/Q28790837
OpenAlex ID: keywords/mutational-signatures
Signatures of mutational processes in human cancer
2013 · Australian Pancreatic Cancer Genome Initiative, Ludmil B. Alexandrov, et al. · Nature · 9,642
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Maftools: efficient and comprehensive analysis of somatic variants in cancer
2018 · Anand Mayakonda, De-Chen Lin, et al. · Genome Research · 4,936
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The repertoire of mutational signatures in human cancer
2020 · Ludmil B. Alexandrov, Jaegil Kim, et al. · Nature · 3,469
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Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
2017 · Ahmet Zehir, Ryma Benayed, et al. · Nature Medicine · 3,372
Pan-cancer analysis of whole genomes
2020 · Lauri A. Aaltonen, Federico Abascal, et al. · Nature · 3,055
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Landscape of somatic mutations in 560 breast cancer whole-genome sequences
2016 · Serena Nik-Zainal, Helen Davies, et al. · Nature · 2,211
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Molecular subtypes of diffuse large B cell lymphoma are associated with distinct pathogenic mechanisms and outcomes
2018 · Bjoern Chapuy, Chip Stewart, et al. · Nature Medicine · 1,936
Mutational Processes Molding the Genomes of 21 Breast Cancers
2012 · Serena Nik-Zainal, Ludmil B. Alexandrov, et al. · Cell · 1,905
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Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets
2015 · Kornelius Schulze, Sandrine Imbeaud, et al. · Nature Genetics · 1,798
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Mapping the Hallmarks of Lung Adenocarcinoma with Massively Parallel Sequencing
2012 · Marcin Imielinski, Alice H. Berger, et al. · Cell · 1,787
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The landscape of cancer genes and mutational processes in breast cancer
2012 · Philip J. Stephens, Patrick S. Tarpey, et al. · Nature · 1,698
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A comprehensive catalogue of somatic mutations from a human cancer genome
2009 · Erin D. Pleasance, R. Keira Cheetham, et al. · Nature · 1,695
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The landscape of genomic alterations across childhood cancers
2018 · ICGC PedBrain-Seq Project, Susanne N. Gröbner, et al. · Nature · 1,566
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Landscape of Microsatellite Instability Across 39 Cancer Types
2017 · Russell Bonneville, Melanie A. Krook, et al. · JCO Precision Oncology · 1,476
Whole-genome landscapes of major melanoma subtypes
2017 · Nicholas K. Hayward, James S. Wilmott, et al. · Nature · 1,461
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A compendium of mutational cancer driver genes
2020 · Francisco Martínez-Jiménez, Ferran Muiños, et al. · Nature reviews. Cancer · 1,296
Genomic spectra of biliary tract cancer
2015 · Hiromi Nakamura, Yasuhito Arai, et al. · Nature Genetics · 1,284
Deciphering Signatures of Mutational Processes Operative in Human Cancer
2013 · Ludmil B. Alexandrov, Serena Nik-Zainal, et al. · Cell Reports · 1,277
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deconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution
2016 · Rachel Rosenthal, Nicholas McGranahan, et al. · Genome biology · 1,215
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Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
2014 · Marco Gerlinger, Stuart Horswell, et al. · Nature Genetics · 1,207
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli
2020 · Cayetano Pleguezuelos-Manzano, Jens Puschhof, et al. · Nature · 1,199
A guide to genome engineering with programmable nucleases
2014 · Hyongbum Kim, Jin-Soo Kim · Nature Reviews Genetics · 1,163
The whole-genome landscape of medulloblastoma subtypes
2017 · Paul A. Northcott, Ivo Buchhalter, et al. · Nature · 1,112
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Mutational signatures associated with tobacco smoking in human cancer
2016 · Ludmil B. Alexandrov, Young Seok Ju, et al. · Science · 1,098
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HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures
2017 · Helen Davies, Dominik Glodzik, et al. · Nature Medicine · 1,080
Works count: 6,924
Citation count: 181,300
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