Keyword

neocryptolepine

Description: A plant-derived indoloquinoline alkaloid studied for its interactions with DNA and its biological activities, including cytotoxic and antimalarial effects.

Primary topic: Synthesis and bioactivity of alkaloids (63%)

OpenAlex ID: keywords/neocryptolepine

In Vitro and in Vivo Antiplasmodial Activity of Cryptolepine and Related Alkaloids from Cryptolepis sanguinolenta

1997 · Kanyanga Cimanga, Tess De Bruyne, et al. · Journal of Natural Products · 255

New alkaloids from Cryptolepis sanguinolenta

1996 · K. Cimanga, T. De Bruyne, et al. · Tetrahedron Letters · 190

Indoloquinolines as Scaffolds for Drug Discovery

2010 · J. Lavrado, R. Moreira, et al. · Current Medicinal Chemistry · 185

Cytotoxicity and cell cycle effects of the plant alkaloids cryptolepine and neocryptolepine: relation to drug-induced apoptosis

2000 · Laurent Dassonneville, Amélie Lansiaux, et al. · European Journal of Pharmacology · 161

Microwave-Assisted Syntheses of N-Heterocycles Using Alkenone-, Alkynone- and Aryl-carbonyl O-Phenyl Oximes: Formal Synthesis of Neocryptolepine

2008 · Fernando Portela-Cubillo, Jackie S. Scott, et al. · The Journal of Organic Chemistry · 151

Interactions of cryptolepine and neocryptolepine with unusual DNA structures

2003 · Lionel Guittat, Patrizia Alberti, et al. · Biochimie · 147

RhII2‐Catalyzed Synthesis of α‐, β‐, or δ‐Carbolines from Aryl Azides

2012 · Ashley L. Pumphrey, Huijun Dong, et al. · Angewandte Chemie International Edition · 126

Isoneocryptolepine, a Synthetic Indoloquinoline Alkaloid, as an Antiplasmodial Lead Compound

2005 · Sabine Van Miert, Steven Hostyn, et al. · Journal of Natural Products · 112

Isolation, Biological Activities and Synthesis of Indoloquinoline Alkaloids: Cryptolepine, Isocryptolepine and Neocryptolepine

2011 · Prakash T. Parvatkar, Perunninakulath S. Parameswaran, et al. · Current Organic Chemistry · 99

Antibacterial and antifungal activities of neocryptolepine, biscryptolepine and cryptoquindoline, alkaloids isolated from Cryptolepis sanguinolenta

1998 · K. Cimanga, T. De Bruyne, et al. · Phytomedicine · 88

Divergent reactions of indoles with aminobenzaldehydes: indole ring-opening vs. annulation and facile synthesis of neocryptolepine

2011 · Matthew K. Vecchione, Aaron X. Sun, et al. · Chemical Science · 87

Structure–activity relationship of antiparasitic and cytotoxic indoloquinoline alkaloids, and their tricyclic and bicyclic analogues

2009 · Gitte Van Baelen, Steven Hostyn, et al. · Bioorganic & Medicinal Chemistry · 84

Formal Total Synthesis of the Alkaloid Cryptotackieine (Neocryptolepine)

1997 · Mateo Alajarín, Pedro Molina, et al. · Journal of Natural Products · 83

Gold-catalyzed annulations of N -aryl ynamides with benzisoxazoles to construct 6 H -indolo[2,3- b ]quinoline cores

2018 · Meng-Han Tsai, Cheng-Yu Wang, et al. · Chemical Communications · 82

Synthesis and Antiplasmodial Activity of Aminoalkylamino-Substituted Neocryptolepine Derivatives

2009 · Ibrahim El Sayed, Pieter Van der Veken, et al. · Journal of Medicinal Chemistry · 82

Synthesis of the benzo-β-carboline isoneocryptolepine: the missing indoloquinoline isomer in the alkaloid series cryptolepine, neocryptolepine and isocryptolepine

2004 · Steven Hostyn, Bert U.W. Maes, et al. · Tetrahedron · 82

An Expeditious I2-Catalyzed Entry into 6H-Indolo[2,3-b]quinoline System of Cryptotackieine

2009 · Prakash T. Parvatkar, Perunninakulath S. Parameswaran, et al. · The Journal of Organic Chemistry · 79

A concise synthesis of indoloquinoline skeletons applying two consecutive Pd-catalyzed reactions

2013 · Borbála Bogányi, Judit Kámán · Tetrahedron · 75

One-Pot Access to Indolo[2,3-b]quinolines by Electrophile-Triggered Cross-Amination/Friedel–Crafts Alkylation of Indoles with 1-(2-Tosylaminophenyl)ketones

2011 · Shaukat Ali, Ying-Xiu Li, et al. · The Journal of Organic Chemistry · 70

Neocryptolepine (Cryprotackieine), A Unique Bioactive Natural Product: Isolation, Synthesis, and Profile of Its Biological Activity

2014 · Andrea B. J. Bracca, Daniel A. Heredia, et al. · European Journal of Organic Chemistry · 64

Synthesis and in vitro antiproliferative activity of new 11-aminoalkylamino-substituted 5H- and 6H-indolo[2,3-b]quinolines; structure–activity relationships of neocryptolepines and 6-methyl congeners

2012 · Li Wang, Marta Świtalska, et al. · Bioorganic & Medicinal Chemistry · 62

Synthesis and antimalarial testing of neocryptolepine analogues: Addition of ester function in SAR study of 2,11-disubstituted indolo[2,3-b]quinolines

2013 · Wen-Jie Lu, Kathryn J. Wicht, et al. · European Journal of Medicinal Chemistry · 61

Synthesis and in Vitro Antimalarial Testing of Neocryptolepines: SAR Study for Improved Activity by Introduction and Modifications of Side Chains at C2 and C11 on Indolo[2,3-b]quinolines

2013 · Zhen-Wu Mei, Li Wang, et al. · Journal of Medicinal Chemistry · 60

DNA intercalation, topoisomerase II inhibition and cytotoxic activity of the plant alkaloid neocryptolepine.

2000 · C Bailly, W Laine, et al. · PubMed · 59

Neocryptolepine: A Promising Indoloisoquinoline Alkaloid with Interesting Biological Activity. Evaluation of the Drug and its Most Relevant Analogs

2015 · Enrique Larghi, Andrea Bracca, et al. · Current Topics in Medicinal Chemistry · 56

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Works count: 113

Citation count: 3,701