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Keyword

NIK

Description: A serine/threonine protein kinase that activates noncanonical NF-κB signaling by regulating the IκB kinase complex.
Wikidata ID: wiki/Q21111335
OpenAlex ID: keywords/nik
NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
1999 · Osman Nidai Ozes, Lindsey D. Mayo, et al. · Nature · 2,172
The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
1998 · Min-Jean Yin, Yumi Yamamoto, et al. · Nature · 1,590
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway
2001 · Uwe Senftleben, Yixue Cao, et al. · Science · 1,359
IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis
2007 · Eugene Varfolomeev, John W. Blankenship, et al. · Cell · 1,214
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Non-canonical NF-κB signaling pathway
2010 · Shao-Cong Sun · Cell Research · 1,198
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The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
1999 · Jun Ninomiya-Tsuji, Kazuya Kishimoto, et al. · Nature · 1,184
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
1997 · John D. Woronicz, Xiong Gao, et al. · Science · 1,182
Identification and Characterization of an IκB Kinase
1997 · Catherine H Régnier, Ho Yeong Song, et al. · Cell · 1,174
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Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma
2007 · Jonathan J. Keats, Rafael Fonseca, et al. · Cancer Cell · 981
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Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma
2007 · Christina M. Annunziata, R. Eric Davis, et al. · Cancer Cell · 950
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The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
2002 · Emmanuel Dejardin, Nathalie M Droin, et al. · Immunity · 922
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NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100
2001 · Gutian Xiao, Edward W Harhaj, et al. · Molecular Cell · 834
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IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain
1999 · Hiroaki Sakurai, Hiroaki Chiba, et al. · Journal of Biological Chemistry · 824
The noncanonical NF‐κB pathway
2012 · Shao‐Cong Sun · Immunological Reviews · 722
Curcumin Blocks Cytokine-Mediated NF-κB Activation and Proinflammatory Gene Expression by Inhibiting Inhibitory Factor I-κB Kinase Activity
1999 · Christian Jobin, Cynthia A Bradham, et al. · The Journal of Immunology · 683
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Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-κB signaling
2008 · Sivakumar Vallabhapurapu, Atsushi Matsuzawa, et al. · Nature Immunology · 608
NF‐κB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK‐related kinase
1999 · Joel L. Pomerantz, David Baltimore · The EMBO Journal · 592
The Human Toll Signaling Pathway: Divergence of Nuclear Factor κB and JNK/SAPK Activation Upstream of Tumor Necrosis Factor Receptor–associated Factor 6 (TRAF6)
1998 · Marta Muzio, Gioacchino Natoli, et al. · The Journal of Experimental Medicine · 574
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Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants
1998 · Luke A J O'Neill, Catherine Greene · Journal of Leukocyte Biology · 561
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Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2
1997 · Ho Yeong Song, Catherine H. Régnier, et al. · Proceedings of the National Academy of Sciences · 553
NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176
1998 · Lei Ling, Zhaodan Cao, et al. · Proceedings of the National Academy of Sciences · 535
NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling
2012 · Irving C. Allen, Justin E. Wilson, et al. · Immunity · 534
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The NF-κB Regulatory Network
2006 · Allan R. Brasier · Cardiovascular Toxicology · 528
Differential regulation of IκB kinase α and β by two upstream kinases, NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1
1998 · Hiroyasu Nakano, Masahisa Shindo, et al. · Proceedings of the National Academy of Sciences · 517
The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance
2008 · Taishin Akiyama, Yusuke Shimo, et al. · Immunity · 501
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Works count: 1,358
Citation count: 74,070
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