Keyword

NK cell dysfunction

Description: Natural killer cell dysfunction is impaired natural killer cell activity, including defects in recognition or killing, associated with disease and altered tissue environments.

Primary topic: Immune Cell Function and Interaction (51%)

OpenAlex ID: keywords/nk-cell-dysfunction

HLH‐2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis

2006 · Jan‐Inge Henter, AnnaCarin Horne, et al. · Pediatric Blood & Cancer · 5,391

Human breast cancer cells enhance self tolerance by promoting evasion from NK cell antitumor immunity

2011 · Emilie Mamessier, Aude Sylvain, et al. · Journal of Clinical Investigation · 681

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma

2020 · Peng-Fei Zhang, Chao Gao, et al. · Molecular Cancer · 596

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Cancer acidity: An ultimate frontier of tumor immune escape and a novel target of immunomodulation

2017 · Veronica Huber, Chiara Camisaschi, et al. · Seminars in Cancer Biology · 591

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Characterization of CD56 – /CD16 + natural killer (NK) cells: A highly dysfunctional NK subset expanded in HIV-infected viremic individuals

2005 · Domenico Mavilio, Gabriella Lombardo, et al. · Proceedings of the National Academy of Sciences · 544

Familial and acquired hemophagocytic lymphohistiocytosis

2006 · Gritta E. Janka · European Journal of Pediatrics · 535

Adult-onset Still's disease

2014 · Mathieu Gerfaud-Valentin, Yvan Jamilloux, et al. · Autoimmunity Reviews · 521

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Hemophagocytic Lymphohistiocytosis

2017 · Hanny Al-Samkari, Nancy Berliner · Annual Review of Pathology Mechanisms of Disease · 508

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Tumor-Infiltrating Natural Killer Cells

2020 · Beatriz Cózar, Marco Greppi, et al. · Cancer Discovery · 477

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Hemophagocytic lymphohistiocytosis. Report of 122 children from the International Registry. FHL Study Group of the Histiocyte Society.

1996 · M Aricò, G Janka, et al. · PubMed · 469

Griscelli disease maps to chromosome 15q21 and is associated with mutations in the Myosin-Va gene

1997 · Elodie Pastural, Franck J. Barrat, et al. · Nature Genetics · 456

Immunometabolism and natural killer cell responses

2019 · Katie L. O’Brien, David K. Finlay · Nature reviews. Immunology · 436

Natural killer cells in HIV-1 infection: Dichotomous effects of viremia on inhibitory and activating receptors and their functional correlates

2003 · Domenico Mavilio, Janet Benjamin, et al. · Proceedings of the National Academy of Sciences · 387

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression

2018 · Jingjing Cong, Xianwei Wang, et al. · Cell Metabolism · 381

Increased expression of programmed cell death protein 1 on NK cells inhibits NK-cell-mediated anti-tumor function and indicates poor prognosis in digestive cancers

2017 · Y Liu, Y Cheng, et al. · Oncogene · 366

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Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection

2005 · Galit Alter, Nickolas Teigen, et al. · Blood · 364

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Thermal- and Oxidative Stress Causes Enhanced Release of NKG2D Ligand-Bearing Immunosuppressive Exosomes in Leukemia/Lymphoma T and B Cells

2011 · Malin Hedlund, Olga Nagaeva, et al. · PLoS ONE · 360

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Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

2011 · Tuanjie Li, Yang Yang, et al. · Cancer Letters · 328

Clinical, Molecular, and Cell Biological Aspects of Chediak–Higashi Syndrome

1999 · Wendy Introne, Raymond E. Boissy, et al. · Molecular Genetics and Metabolism · 316

NK cells and human pregnancy – an inflammatory view

2006 · Ian L. Sargent, Angela M. Borzychowski, et al. · Trends in Immunology · 312

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

2021 · Sophie M. Poznanski, Kanwaldeep Singh, et al. · Cell Metabolism · 309

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Tumor Necrosis Factor-α Blocks Differentiation and Enhances Suppressive Activity of Immature Myeloid Cells during Chronic Inflammation

2013 · Moshe Sade-Feldman, Julia Kanterman, et al. · Immunity · 307

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Impaired immune responses in diabetes mellitus: analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections.

1992 · M P Moutschen, A J Scheen, et al. · PubMed · 303

Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients

2008 · Lun Cai, Zheng Zhang, et al. · Clinical Immunology · 288

Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome

2003 · Alexei A. Grom, Joyce Villanueva, et al. · The Journal of Pediatrics · 285

Works count: 1,642

Citation count: 46,970