Keyword

nm23-H1

Description: A human protein, also called NME1, studied as a metastasis suppressor and regulator of cellular signaling in cancer biology.

Primary topic: Mechanisms of cancer metastasis (51%)

OpenAlex ID: keywords/nm23-h1

Tumor Suppressor NM23-H1 Is a Granzyme A-Activated DNase during CTL-Mediated Apoptosis, and the Nucleosome Assembly Protein SET Is Its Inhibitor

2003 · Zusen Fan, Paul J. Beresford, et al. · Cell · 541

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Granzyme A Induces Caspase-Independent Mitochondrial Damage, a Required First Step for Apoptosis

2005 · Denis Martinvalet, Pengcheng Zhu, et al. · Immunity · 408

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Identification of a second human nm23 gene, nm23-H2.

1991 · J A Stahl, A Leone, et al. · PubMed · 353

ARF6-GTP recruits Nm23-H1 to facilitate dynamin-mediated endocytosis during adherens junctions disassembly

2002 · Felipe Palacios, Jill K. Schweitzer, et al. · Nature Cell Biology · 303

Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity.

1993 · A Leone, U Flatow, et al. · PubMed · 296

New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis

1999 · J Tian, Z Y Tang, et al. · British Journal of Cancer · 281

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The Exonuclease TREX1 Is in the SET Complex and Acts in Concert with NM23-H1 to Degrade DNA during Granzyme A-Mediated Cell Death

2006 · Dipanjan Chowdhury, Paul J. Beresford, et al. · Molecular Cell · 264

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High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification.

1991 · N Hailat, D R Keim, et al. · Journal of Clinical Investigation · 228

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The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells

2002 · Alfonso Baldi, Antonio De Luca, et al. · Oncogene · 202

Nm23-H1 Metastasis Suppressor Phosphorylation of Kinase Suppressor of Ras via a Histidine Protein Kinase Pathway

2002 · Melanie T. Hartsough, Deborah K. Morrison, et al. · Journal of Biological Chemistry · 201

Nuclear war: the granzyme A-bomb

2003 · Judy Lieberman, Zusen Fan · Current Opinion in Immunology · 200

Strand-Specific miR-28-5p and miR-28-3p Have Distinct Effects in Colorectal Cancer Cells

2012 · Maria I. Almeida, Milena S. Nicoloso, et al. · Gastroenterology · 198

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Identification of Nicotinamide N -Methyltransferase as a Novel Serum Tumor Marker for Colorectal Cancer

2005 · Markus Roeßler, Wolfgang Rollinger, et al. · Clinical Cancer Research · 197

Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas.

1993 · A Leone, R C Seeger, et al. · PubMed · 197

Tumor metastasis suppressor nm23H1 regulates Rac1 GTPase by interaction with Tiam1

2001 · Yoshiro Otsuki, Masamitsu Tanaka, et al. · Proceedings of the National Academy of Sciences · 191

Metastasis Suppression: The Evolving Role of Metastasis Suppressor Genes for Regulating Cancer Cell Growth at the Secondary Site

2003 · ERIC C. KAUFFMAN, VICTORIA L. ROBINSON, et al. · The Journal of Urology · 184

Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling

2014 · Mathieu Boissan, Guillaume Montagnac, et al. · Science · 178

Targeting SET/I2PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy

2011 · C H Switzer, R Y S Cheng, et al. · Oncogene · 171

Separating favorable from unfavorable prognostic markers in breast cancer: the role of E-cadherin.

2000 · R Heimann, F Lan, et al. · PubMed · 170

Somatic allelic deletion of nm23 in human cancer.

1991 · A Leone, O W McBride, et al. · PubMed · 159

Implication of Metastasis Suppressor NM23-H1 in Maintaining Adherens Junctions and Limiting the Invasive Potential of Human Cancer Cells

2010 · Mathieu Boissan, Olivier De Wever, et al. · Cancer Research · 158

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A Novel Function for the nm23-H1 Gene: Overexpression in Human Breast Carcinoma Cells Leads to the Formation of Basement Membrane and Growth Arrest

1994 · A. R. Howlett, O. W. Petersen, et al. · JNCI Journal of the National Cancer Institute · 154

Identification of S100A8 and S100A9 as Serological Markers for Colorectal Cancer

2009 · Hye-Jung Kim, Hye-Jung Kim, et al. · Journal of Proteome Research · 151

Effect of Inhibition of the Lysophosphatidic Acid Receptor 1 on Metastasis and Metastatic Dormancy in Breast Cancer

2012 · Jean-Claude A. Marshall, Joshua W. Collins, et al. · JNCI Journal of the National Cancer Institute · 150

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Proliferation-related expression of p19/nm23 nucleoside diphosphate kinase.

1992 · D Keim, N Hailat, et al. · Journal of Clinical Investigation · 147

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Works count: 2,042

Citation count: 25,880