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NRAS mutation

Description: An NRAS mutation is a genetic alteration in the NRAS gene, studied for its role in cell signaling and diseases including cancer.
Wikidata ID: wiki/Q28444972
OpenAlex ID: keywords/nras-mutation
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
2012 · Jordi Barretina, Giordano Caponigro, et al. · Nature · 7,928
Distinct Sets of Genetic Alterations in Melanoma
2005 · John A. Curtin, Jane Fridlyand, et al. · New England Journal of Medicine · 2,750
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Diagnosis and Treatment of Metastatic Colorectal Cancer
2021 · Leah H. Biller, Deborah Schrag · JAMA · 2,609
Recurring Mutations Found by Sequencing an Acute Myeloid Leukemia Genome
2009 · Elaine R. Mardis, Li Ding, et al. · New England Journal of Medicine · 2,219
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Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
2010 · Ramin Nazarian, Hubing Shi, et al. · Nature · 2,193
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
2010 · Wendy De Roock, Bart Claes, et al. · The Lancet Oncology · 2,144
Mutations and Treatment Outcome in Cytogenetically Normal Acute Myeloid Leukemia
2008 · Richard F. Schlenk, Konstanze Döhner, et al. · New England Journal of Medicine · 1,629
Targeting RAS–ERK signalling in cancer: promises and challenges
2014 · Ahmed A. Samatar, Poulikos I. Poulikakos · Nature Reviews Drug Discovery · 1,159
The Genetic Evolution of Melanoma from Precursor Lesions
2015 · A. Hunter Shain, Iwei Yeh, et al. · New England Journal of Medicine · 1,070
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Widespread Genetic Heterogeneity in Multiple Myeloma: Implications for Targeted Therapy
2014 · Jens G. Lohr, Petar Stojanov, et al. · Cancer Cell · 986
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The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
2017 · Hamid Bolouri, Jason E Farrar, et al. · Nature Medicine · 849
Selumetinib-Enhanced Radioiodine Uptake in Advanced Thyroid Cancer
2013 · Alan L. Ho, Ravinder K. Grewal, et al. · New England Journal of Medicine · 843
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Fluorouracil, Leucovorin, and Irinotecan Plus Cetuximab Treatment and RAS Mutations in Colorectal Cancer
2015 · Eric Van Cutsem, Heinz-Josef Lenz, et al. · Journal of Clinical Oncology · 790
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Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype
2005 · Susanne Schnittger, Claudia Schoch, et al. · Blood · 713
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NRAS mutation status is an independent prognostic factor in metastatic melanoma
2011 · John A. Jakob, Roland L. Bassett, et al. · Cancer · 690
KIT Gene Mutations and Copy Number in Melanoma Subtypes
2008 · Carol Beadling, Erick Jacobson-Dunlop, et al. · Clinical Cancer Research · 647
Consensus recommendations for the diagnosis and clinical management of Rosai-Dorfman-Destombes disease
2018 · Oussama Abla, Eric Jacobsen, et al. · Blood · 644
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Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis
2006 · T Eisen, T Ahmad, et al. · British Journal of Cancer · 644
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MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study
2013 · Paolo A Ascierto, Dirk Schadendorf, et al. · The Lancet Oncology · 638
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
2005 · Roel G. W. Verhaak, Chantal S. Goudswaard, et al. · Blood · 618
Melanoma
2015 · Dirk Schadendorf, David E. Fisher, et al. · Nature Reviews Disease Primers · 613
Imatinib for Melanomas Harboring Mutationally Activated or Amplified KIT Arising on Mucosal, Acral, and Chronically Sun-Damaged Skin
2013 · F. Stephen Hodi, Christopher L. Corless, et al. · Journal of Clinical Oncology · 608
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Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAF V600E-Mutant Colorectal Cancer
2018 · Ryan B. Corcoran, Thierry André, et al. · Cancer Discovery · 588
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Correlative morphologic and molecular genetic analysis demonstrates three distinct categories of posttransplantation lymphoproliferative disorders
1995 · DM Knowles, E Cesarman, et al. · Blood · 584
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Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced Cancers
2008 · Alex A. Adjei, Roger B. Cohen, et al. · Journal of Clinical Oncology · 570
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Works count: 5,378
Citation count: 134,900
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