Keyword

Nrf2

Description: Nrf2 is a transcription factor that regulates cellular antioxidant and stress-response genes, studied in contexts including aging, cancer, and neurodegenerative disease.

Primary topic: Genomics, phytochemicals, and oxidative stress (24%)

OpenAlex ID: keywords/nrf2

Oxidative stress, inflammation, and cancer: How are they linked?

2010 · Simone Reuter, Subash C. Gupta, et al. · Free Radical Biology and Medicine · 5,434

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

2020 · Helmut Sies, Dean P. Jones · Nature Reviews Molecular Cell Biology · 5,292

Role of Nrf2 in Oxidative Stress and Toxicity

2013 · Qiang Ma · The Annual Review of Pharmacology and Toxicology · 4,882

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

2012 · Paul D. Ray, Bo-Wen Huang, et al. · Cellular Signalling · 4,371

Ferroptosis: molecular mechanisms and health implications

2020 · Daolin Tang, Xin Chen, et al. · Cell Research · 4,274

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Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1

1999 · Zhidan Wu, Pere Puigserver, et al. · Cell · 4,135

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Comprehensive genomic characterization of head and neck squamous cell carcinomas

2015 · The Cancer Genome Atlas Network · Nature · 4,051

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An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 · Ken Itoh, Tomoki Chiba, et al. · Biochemical and Biophysical Research Communications · 3,983

Comprehensive genomic characterization of squamous cell lung cancers

2012 · Peter S. Hammerman, Michael S. Lawrence, et al. · Nature · 3,973

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Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway

2006 · Thomas W. Kensler, Nobunao Wakabayashi, et al. · The Annual Review of Pharmacology and Toxicology · 3,617

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 · Ken Itoh, Nobunao Wakabayashi, et al. · Genes & Development · 3,610

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Glutathione Transferases

2004 · John D. Hayes, Jack U. Flanagan, et al. · The Annual Review of Pharmacology and Toxicology · 3,565

Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression

2017 · Masahiro Nezu, Norio Suzuki, et al. · American Journal of Nephrology · 3,446

Oncogenic Signaling Pathways in The Cancer Genome Atlas

2018 · Francisco Sanchez-Vega, Marco Mina, et al. · Cell · 3,181

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The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress

2009 · Truyen Nguyen, Paul Nioi, et al. · Journal of Biological Chemistry · 2,649

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Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

2016 · Agnieszka Loboda, Milena Damulewicz, et al. · Cellular and Molecular Life Sciences · 2,642

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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

2019 · Matthew Dodson, Raul Castro-Portuguez, et al. · Redox Biology · 2,420

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The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

2010 · Masaaki Komatsu, Hirofumi Kurokawa, et al. · Nature Cell Biology · 2,410

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

2011 · Gina M. DeNicola, Florian A. Karreth, et al. · Nature · 2,270

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

2004 · Akira Kobayashi, Moon-Il Kang, et al. · Molecular and Cellular Biology · 2,216

Transcriptional Regulation by Nrf2

2017 · Claudia Tonelli, Iok In Christine Chio, et al. · Antioxidants and Redox Signaling · 2,200

Glutathione synthesis

2012 · Shelly C. Lu · Biochimica et Biophysica Acta (BBA) - General Subjects · 2,179

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

2014 · John D. Hayes, Albena T. Dinkova-Kostova · Trends in Biochemical Sciences · 2,146

Regulation of glutathione synthesis

2008 · Shelly C. Lu · Molecular Aspects of Medicine · 2,125

Nrf2-Keap1 signaling in oxidative and reductive stress

2018 · Ilaria Bellezza, Ileana Giambanco, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2,063

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Works count: 37,930

Citation count: 1,230,000