Keyword

NXY-059

Description: An experimental nitrone-based free-radical-trapping compound investigated as a neuroprotective treatment for acute ischemic stroke.

Primary topic: Acute Ischemic Stroke Management (47%)

Wikidata ID: wiki/Q72496983

OpenAlex ID: keywords/nxy-059

NXY-059 for the Treatment of Acute Ischemic Stroke

2007 · Ashfaq Shuaib, Kennedy R. Lees, et al. · New England Journal of Medicine · 732

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NXY-059 for Acute Ischemic Stroke

2006 · Kennedy R. Lees, Justin A. Zivin, et al. · New England Journal of Medicine · 661

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

2008 · Malcolm R. Macleod, H. Bart van der Worp, et al. · Stroke · 318

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Future of neuroprotection for acute stroke: In the aftermath of the SAINT trials

2007 · Sean I. Savitz, Marc Fisher · Annals of Neurology · 265

Neuroprotection for Ischaemic Stroke: Translation from the Bench to the Bedside

2012 · Brad A. Sutherland, Jens Minnerup, et al. · International Journal of Stroke · 260

NXY-059 for the Treatment of Acute Stroke

2008 · Hans-Christoph Diener, Kennedy R. Lees, et al. · Stroke · 255

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Neuroprotective Effects of a Novel Nitrone, NXY-059, after Transient Focal Cerebral Ischemia in the Rat

1999 · Satoshi Kuroda, Ryoichi Tsuchidate, et al. · Journal of Cerebral Blood Flow & Metabolism · 247

Neuroprotection for Stroke: Current Status and Future Perspectives

2012 · Jens Minnerup, Brad A. Sutherland, et al. · International Journal of Molecular Sciences · 206

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Tissue Plasminogen Activator (tPA) and Matrix Metalloproteinases in the Pathogenesis of Stroke: Therapeutic Strategies

2008 · Rao Adibhatla, James Hatcher · CNS & Neurological Disorders - Drug Targets · 196

Prophylactic Antiepileptic Drug Use is Associated with Poor Outcome Following ICH

2009 · for the CHANT investigators, Steven R. Messé, et al. · Neurocritical Care · 185

NXY-059, a Free Radical–Trapping Agent, Substantially Lessens the Functional Disability Resulting From Cerebral Ischemia in a Primate Species

2001 · Jonathan W. B. Marshall, Katharine J. Duffin, et al. · Stroke · 181

Pharmacological approaches to acute ischaemic stroke: reperfusion certainly, neuroprotection possibly

2007 · A R Green · British Journal of Pharmacology · 179

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Safety and Tolerability of NXY-059 for Acute Intracerebral Hemorrhage

2007 · Patrick D. Lyden, Ashfaq Shuaib, et al. · Stroke · 174

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Therapeutic strategies for the treatment of stroke

2006 · A. Richard Green, Ashfaq Shuaib · Drug Discovery Today · 157

Prior antiplatelet use does not affect hemorrhage growth or outcome after ICH

2009 · L. H. Sansing, S. R. Messe, et al. · Neurology · 155

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Effect of NXY‐059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window

2002 · S G Sydserff, A R Borelli, et al. · British Journal of Pharmacology · 154

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Methodological Quality of Animal Studies of Neuroprotective Agents Currently in Phase II/III Acute Ischemic Stroke Trials

2008 · Maria Philip, Michael Benatar, et al. · Stroke · 135

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A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: A need for more rigorous testing of neuroprotective agents in animal models of stroke

2007 · S SAVITZ · Experimental Neurology · 134

Functional and Histological Evidence for the Protective Effect of NXY-059 in a Primate Model of Stroke When Given 4 Hours After Occlusion

2003 · Jonathan W.B. Marshall, Rosalyn M. Cummings, et al. · Stroke · 132

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Prior Antiplatelet Use Does Not Affect Hemorrhage Growth or Outcome After Ich 2

2010 · Andrew M. Naidech, Richard A. Bernstein, et al. · Neurology · 126

Effects of NXY‐059 in experimental stroke: an individual animal meta‐analysis

2009 · PMW Bath, LJ Gray, et al. · British Journal of Pharmacology · 122

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Missing Steps in the STAIR Case: A Translational Medicine Perspective on the Development of NXY-059 for Treatment of Acute Ischemic Stroke

2007 · Giora Z Feuerstein, Margaret M Zaleska, et al. · Journal of Cerebral Blood Flow & Metabolism · 121

Shift Analysis Versus Dichotomization of the Modified Rankin Scale Outcome Scores in the NINDS and ECASS-II Trials

2007 · Sean I. Savitz, Robert Lew, et al. · Stroke · 118

Free Radical Trapping as a Therapeutic Approach to Neuroprotection in Stroke: Experimental and Clinical Studies with NXY-059 and Free Radical Scavengers

2005 · A. Green, Tim Ashwood · CNS & Neurological Disorders - Drug Targets · 113

Efficacy of disodium 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (NXY-059), a free radical trapping agent, in a rat model of hemorrhagic stroke

2001 · James Peeling, Marc R Del Bigio, et al. · Neuropharmacology · 113

Works count: 181

Citation count: 8,655