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Keyword

off-target effects

Description: Off-target effects are unintended changes or actions at sites other than the intended target, especially in gene editing and molecular biology.
OpenAlex ID: keywords/off-target-effects
Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
2013 · Lei S. Qi, Matthew H. Larson, et al. · Cell · 5,003
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DNA targeting specificity of RNA-guided Cas9 nucleases
2013 · Patrick D Hsu, David A Scott, et al. · Nature Biotechnology · 4,737
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Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 · John G Doench, Nicolo Fusi, et al. · Nature Biotechnology · 4,620
Specificity and mechanism of action of some commonly used protein kinase inhibitors
2000 · Stephen P. DAVIES, Helen REDDY, et al. · Biochemical Journal · 4,039
Effects of Torcetrapib in Patients at High Risk for Coronary Events
2007 · Philip J. Barter, Mark Caulfield, et al. · New England Journal of Medicine · 3,150
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Specificity and mechanism of action of some commonly used protein kinase inhibitors
2000 · Stephen P. DAVIES, Helen REDDY, et al. · Biochemical Journal · 3,133
Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation
2014 · Luke A. Gilbert, Max A. Horlbeck, et al. · Cell · 2,724
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The selectivity of protein kinase inhibitors: a further update
2007 · Jenny Bain, Lorna Plater, et al. · Biochemical Journal · 2,522
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A quantitative analysis of kinase inhibitor selectivity
2008 · Mazen W Karaman, Sanna Herrgard, et al. · Nature Biotechnology · 2,431
Rationally engineered Cas9 nucleases with improved specificity
2015 · Ian M. Slaymaker, Linyi Gao, et al. · Science · 2,415
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
2013 · Daniel Martinez Molina, Rozbeh Jafari, et al. · Science · 2,219
CRISPR–Cas9 Structures and Mechanisms
2017 · Fuguo Jiang, Jennifer A. Doudna · Annual Review of Biophysics · 2,020
Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements
2018 · Michael Kosicki, Kärt Tomberg, et al. · Nature Biotechnology · 1,877
Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins
2014 · Sojung Kim, Daesik Kim, et al. · Genome Research · 1,850
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Predicting new molecular targets for known drugs
2009 · Michael J. Keiser, Vincent Setola, et al. · Nature · 1,665
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
2015 · Benjamin P. Kleinstiver, Michelle S. Prew, et al. · Nature · 1,626
Therapeutic siRNA: state of the art
2020 · Bo Hu, Liping Zhong, et al. · Signal Transduction and Targeted Therapy · 1,576
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A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes
2010 · Dongmei Sun, Xiaoying Zhuang, et al. · Molecular Therapy · 1,575
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Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
2018 · Johnny H. Hu, Shannon M. Miller, et al. · Nature · 1,551
Specific Effects of MicroRNAs on the Plant Transcriptome
2005 · Rebecca Schwab, Javier F. Palatnik, et al. · Developmental Cell · 1,468
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Induced protein degradation: an emerging drug discovery paradigm
2016 · Ashton C. Lai, Craig M. Crews · Nature Reviews Drug Discovery · 1,424
Activation of the interferon system by short-interfering RNAs
2003 · Carol A. Sledz, Michelle Holko, et al. · Nature Cell Biology · 1,400
Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases
2013 · Seung Woo Cho, Sojung Kim, et al. · Genome Research · 1,354
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Off-target Effects in CRISPR/Cas9-mediated Genome Engineering
2015 · Xiao-Hui Zhang, Louis Y Tee, et al. · Molecular Therapy — Nucleic Acids · 1,272
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CRISPR–Cas9 genome editing induces a p53-mediated DNA damage response
2018 · Emma Haapaniemi, Sandeep Botla, et al. · Nature Medicine · 1,263
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Works count: 12,460
Citation count: 381,100
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