Keyword

onconase

Description: Onconase, also known as ranpirnase, is a cytotoxic ribonuclease enzyme originally isolated from the eggs of a frog.

Primary topic: Toxin Mechanisms and Immunotoxins (53%)

Wikidata ID: wiki/Q7293428

OpenAlex ID: keywords/onconase

A cytotoxic ribonuclease. Study of the mechanism of onconase cytotoxicity

1993 · Y. Wu, S.M. Mikulski, et al. · Journal of Biological Chemistry · 223

Ribonuclease A variants with potent cytotoxic activity

1998 · Peter A. Leland, L. Wayne Schultz, et al. · Proceedings of the National Academy of Sciences · 222

Role of the N Terminus in RNase A Homologues: Differences in Catalytic Activity, Ribonuclease Inhibitor Interaction and Cytotoxicity

1996 · Ester Boix, YouNeng Wu, et al. · Journal of Molecular Biology · 186

Cancer chemotherapy – ribonucleases to the rescue

2001 · Peter A Leland, Ronald T Raines · Chemistry & Biology · 176

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Cell‐free protein synthesis of a cytotoxic cancer therapeutic: Onconase production and a just‐add‐water cell‐free system

2015 · Amin S. M. Salehi, Mark Thomas Smith, et al. · Biotechnology Journal · 145

Molecular determinants of apoptosis induced by the cytotoxic ribonuclease onconase: evidence for cytotoxic mechanisms different from inhibition of protein synthesis.

2000 · M S Iordanov, O P Ryabinina, et al. · PubMed · 133

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Refined 1·7 Å X-ray crystallographic structure of P-30 protein, an amphibian ribonuclease with anti-tumor activity

1994 · S.C. Mosimann, W. Ardelt, et al. · Journal of Molecular Biology · 126

Ribonuclease inhibitor as an intracellular sentry

2003 · M. C. Haigis · Nucleic Acids Research · 123

Ribonucleases as potential modalities in anticancer therapy

2009 · Wojciech Ardelt, Barbara Ardelt, et al. · European Journal of Pharmacology · 116

Potent and specific antitumor effects of an anti-CD22–targeted cytotoxic ribonuclease: potential for the treatment of non-Hodgkin lymphoma

2001 · Dianne L. Newton, Hans J. Hansen, et al. · Blood · 110

Ribonucleases of different origins with a wide spectrum of medicinal applications

2010 · Evandro Fei Fang, Tzi Bun Ng · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · 109

Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity

2008 · Thomas Rutkoski, Ronald Raines · Current Pharmaceutical Biotechnology · 106

Entry into Cells and Selective Degradation of tRNAs by a Cytotoxic Member of the RNase A Family

2002 · Shailendra K. Saxena, Ravi Sirdeshmukh, et al. · Journal of Biological Chemistry · 105

Onconase and Amphinase, the Antitumor Ribonucleases from Rana pipiens Oocytes

2008 · W. Ardelt, K. Shogen, et al. · Current Pharmaceutical Biotechnology · 102

From housekeeper to microsurgeon: The diagnostic and therapeutic potential of ribonucleases

1997 · Catherine H. Schein · Nature Biotechnology · 96

A Study of the Intracellular Routing of Cytotoxic Ribonucleases

1995 · YouNeng Wu, Shailendra K. Saxena, et al. · Journal of Biological Chemistry · 96

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Binase and other microbial RNases as potential anticancer agents

2008 · Alexander A. Makarov, Alexander Kolchinsky, et al. · BioEssays · 93

Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway

2002 · Marcia C. Haigis, Ronald T. Raines · Journal of Cell Science · 92

Agents from amphibians with anticancer properties

2008 · Chuang-Xin Lu, Ke-Jun Nan, et al. · Anti-Cancer Drugs · 91

Ribonucleases and their antitumor activity

2001 · Josef Matoušek · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · 89

Conformational Stability Is a Determinant of Ribonuclease A Cytotoxicity

2000 · Tony A. Klink, Ronald T. Raines · Journal of Biological Chemistry · 89

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Inhibition of HIV-1 Production and Selective Degradation of Viral RNA by an Amphibian Ribonuclease

1996 · Shailendra K. Saxena, Maneth Gravell, et al. · Journal of Biological Chemistry · 87

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Endowing Human Pancreatic Ribonuclease with Toxicity for Cancer Cells

2001 · Peter A. Leland, Kristine E. Staniszewski, et al. · Journal of Biological Chemistry · 82

X-ray Crystallographic Structure of Recombinant Eosinophil-derived Neurotoxin at 1.83 Å Resolution

1996 · Steven C. Mosimann, Dianne L. Newton, et al. · Journal of Molecular Biology · 81

Removal of N‐terminal methionine from recombinant proteins by engineered E. coli methionine aminopeptidase

2004 · You‐Di Liao, Jen‐Chong Jeng, et al. · Protein Science · 80

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Works count: 317

Citation count: 7,885