Keyword

Orai1

Description: A membrane protein that forms a pore in calcium-release-activated calcium channels and supports store-operated calcium entry into cells.

Primary topic: Ion Channels and Receptors (60%)

Related topic: Ion Channels and Receptors (60%)

OpenAlex ID: keywords/orai1

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

2006 · Stefan Feske, Yousang Gwack, et al. · Nature · 2,288

Orai1 is an essential pore subunit of the CRAC channel

2006 · Murali Prakriya, Stefan Feske, et al. · Nature · 1,343

STIM1 Clusters and Activates CRAC Channels via Direct Binding of a Cytosolic Domain to Orai1

2009 · Chan Young Park, Paul J. Hoover, et al. · Cell · 954

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Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai

2006 · Andriy V. Yeromin, Shenyuan L. Zhang, et al. · Nature · 817

Molecular Basis of Calcium Signaling in Lymphocytes: STIM and ORAI

2010 · Patrick G. Hogan, Richard S. Lewis, et al. · Annual Review of Immunology · 760

Orai1 and STIM1 Are Critical for Breast Tumor Cell Migration and Metastasis

2009 · Shengyu Yang, J. Jillian Zhang, et al. · Cancer Cell · 742

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STIM2 Is a Feedback Regulator that Stabilizes Basal Cytosolic and Endoplasmic Reticulum Ca2+ Levels

2007 · Onn Brandman, Jen Liou, et al. · Cell · 698

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SOAR and the polybasic STIM1 domains gate and regulate Orai channels

2009 · Joseph P. Yuan, Weizhong Zeng, et al. · Nature Cell Biology · 671

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER–plasma membrane junctions

2006 · Riina M. Luik, Minnie M. Wu, et al. · The Journal of Cell Biology · 644

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Calcium in tumour metastasis: new roles for known actors

2011 · Natalia Prevarskaya, Roman Skryma, et al. · Nature reviews. Cancer · 605

The functional network of ion channels in T lymphocytes

2009 · Michael D. Cahalan, K. George Chandy · Immunological Reviews · 599

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

2006 · Christine Peinelt, Monika Vig, et al. · Nature Cell Biology · 581

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

2008 · Riina M. Luik, Bin Wang, et al. · Nature · 578

PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

2013 · Francesca Giordano, Yasunori Saheki, et al. · Cell · 575

Calcium signaling in platelets

2009 · D. VARGA‐SZABO, A. BRAUN, et al. · Journal of Thrombosis and Haemostasis · 563

CRACM1 Multimers Form the Ion-Selective Pore of the CRAC Channel

2006 · Monika Vig, Andreas Beck, et al. · Current Biology · 554

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Orai1 and STIM Reconstitute Store-operated Calcium Channel Function

2006 · Jonathan Soboloff, Maria A. Spassova, et al. · Journal of Biological Chemistry · 549

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Large Store-operated Calcium Selective Currents Due to Co-expression of Orai1 or Orai2 with the Intracellular Calcium Sensor, Stim1

2006 · Jason C. Mercer, Wayne I. DeHaven, et al. · Journal of Biological Chemistry · 546

STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity

2009 · Capucine Picard, Christie-Ann McCarl, et al. · New England Journal of Medicine · 510

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Diseases caused by mutations in ORAI1 and STIM1

2015 · Rodrigo S. Lacruz, Stefan Feske · Annals of the New York Academy of Sciences · 443

Dynamic Assembly of TRPC1-STIM1-Orai1 Ternary Complex Is Involved in Store-operated Calcium Influx

2007 · Hwei Ling Ong, Kwong Tai Cheng, et al. · Journal of Biological Chemistry · 435

Dynamic Coupling of the Putative Coiled-coil Domain of ORAI1 with STIM1 Mediates ORAI1 Channel Activation

2008 · Martin Muik, Irene Frischauf, et al. · Journal of Biological Chemistry · 407

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Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release–activated calcium channels

2007 · Monika Vig, Wayne I DeHaven, et al. · Nature Immunology · 403

Biochemical and Functional Characterization of Orai Proteins

2007 · Yousang Gwack, Sonal Srikanth, et al. · Journal of Biological Chemistry · 381

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Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation

2008 · Iskandar F. Abdullaev, Jonathan M. Bisaillon, et al. · Circulation Research · 373

Works count: 3,314

Citation count: 97,860