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orexin
Description:
Orexins are neuropeptides produced in the brain that regulate arousal, sleep–wake cycles, feeding, and other physiological processes.
Primary topic:
Sleep and Wakefulness Research (51%)
Related topics:
Sleep and Wakefulness Research (51%),
Regulation of Appetite and Obesity (12%)
OpenAlex ID:
keywords/orexin
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
1998
·
L. de Lecea
, T. S. Kilduff
, et al.
·
Proceedings of the National Academy of Sciences
·
3,879
Neurons Containing Hypocretin (Orexin) Project to Multiple Neuronal Systems
1998
·
Christelle Peyron
, Devin K. Tighe
, et al.
·
Journal of Neuroscience
·
3,468
PDF
Narcolepsy in orexin Knockout Mice
1999
·
Richard M. Chemelli
, Jon T. Willie
, et al.
·
Cell
·
3,095
PDF
The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene
1999
·
Ling Lin
, Juliette Faraco
, et al.
·
Cell
·
2,615
PDF
A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
2000
·
Christelle Peyron
, Juliette Faraco
, et al.
·
Nature Medicine
·
2,120
Orexin activation counteracts decreases in nonexercise activity thermogenesis (NEAT) caused by high-fat diet
2017
·
P.E. Bunney
, A.N. Zink
, et al.
·
Physiology & Behavior
·
2,102
Reduced Number of Hypocretin Neurons in Human Narcolepsy
2000
·
Thomas C. Thannickal
, Robert Y. Moore
, et al.
·
Neuron
·
2,089
PDF
Hypocretin (orexin) deficiency in human narcolepsy
2000
·
Seiji Nishino
, Beth Ripley
, et al.
·
The Lancet
·
1,779
Differential expression of orexin receptors 1 and 2 in the rat brain
2001
·
Jacob N. Marcus
, Carl J. Aschkenasi
, et al.
·
The Journal of Comparative Neurology
·
1,659
Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle
2009
·
Jae-Eun Kang
, Miranda M. Lim
, et al.
·
Science
·
1,559
Interacting Appetite-Regulating Pathways in the Hypothalamic Regulation of Body Weight
1999
·
Satya P. Kalra
, Michael G. Dube
, et al.
·
Endocrine Reviews
·
1,554
Genetic Ablation of Orexin Neurons in Mice Results in Narcolepsy, Hypophagia, and Obesity
2001
·
Junko Hara
, Carsten T. Beuckmann
, et al.
·
Neuron
·
1,403
PDF
Neural substrates of awakening probed with optogenetic control of hypocretin neurons
2007
·
Antoine R. Adamantidis
, Feng Zhang
, et al.
·
Nature
·
1,338
A role for lateral hypothalamic orexin neurons in reward seeking
2005
·
Glenda C. Harris
, Mathieu Wimmer
, et al.
·
Nature
·
1,311
The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
2007
·
Takeshi Sakurai
·
Nature reviews. Neuroscience
·
1,273
The Role of Cerebrospinal Fluid Hypocretin Measurement in the Diagnosis of Narcolepsy and Other Hypersomnias
2002
·
Emmanuel Mignot
, Gert Jan Lammers
, et al.
·
Archives of Neurology
·
1,127
The Need to Feed
2002
·
Clifford B. Saper
, Thomas C. Chou
, et al.
·
Neuron
·
1,120
PDF
Distribution of orexin neurons in the adult rat brain
1999
·
Tadahiro Nambu
, Takeshi Sakurai
, et al.
·
Brain Research
·
1,069
A Role for Brain Stress Systems in Addiction
2008
·
George F. Koob
·
Neuron
·
1,057
PDF
Distribution of orexin receptor mRNA in the rat brain
1998
·
Prashant Trivedi
, Hong Yu
, et al.
·
FEBS Letters
·
978
PDF
The tempted brain eats: Pleasure and desire circuits in obesity and eating disorders
2010
·
Kent C. Berridge
, Chao-Yi Ho
, et al.
·
Brain Research
·
871
Discharge of Identified Orexin/Hypocretin Neurons across the Sleep-Waking Cycle
2005
·
Maan Gee Lee
, Oum K. Hassani
, et al.
·
Journal of Neuroscience
·
871
PDF
Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
1998
·
Carol F. Elias
, Clifford B. Saper
, et al.
·
The Journal of Comparative Neurology
·
852
Behavioral Correlates of Activity in Identified Hypocretin/Orexin Neurons
2005
·
Boris Y. Mileykovskiy
, Lyudmila I. Kiyashchenko
, et al.
·
Neuron
·
850
PDF
Associations between Sleep Loss and Increased Risk of Obesity and Diabetes
2008
·
Kristen L. Knutson
, Eve Van Cauter
·
Annals of the New York Academy of Sciences
·
808
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Works count:
6,538
Citation count:
218,900
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