Keyword

p110α

Description: The p110α protein is the catalytic alpha subunit of class I phosphoinositide 3-kinase, an enzyme involved in intracellular signaling.

Primary topic: PI3K/AKT/mTOR signaling in cancer (54%)

Wikidata ID: wiki/Q7117823

OpenAlex ID: keywords/p110alpha

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

2006 · Zachary A. Knight, Beatriz Gonzalez, et al. · Cell · 1,160

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PIK3CA is implicated as an oncogene in ovarian cancer

1999 · Laleh Shayesteh, Yiling Lu, et al. · Nature Genetics · 1,155

Oncogenic PI3K deregulates transcription and translation

2005 · Andreas G. Bader, Sohye Kang, et al. · Nature reviews. Cancer · 798

RAS Interaction with PI3K: More Than Just Another Effector Pathway

2011 · E. Castellano, J. Downward · Genes & Cancer · 756

Suppression of insulin feedback enhances the efficacy of PI3K inhibitors

2018 · Benjamin D. Hopkins, Chantal Pauli, et al. · Nature · 703

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Wortmannin Inactivates Phosphoinositide 3-Kinase by Covalent Modification of Lys-802, a Residue Involved in the Phosphate Transfer Reaction

1996 · Matthias P. Wymann, Ginette Bulgarelli-Leva, et al. · Molecular and Cellular Biology · 682

The PIK3CA gene is mutated with high frequency in human breast cancers

2004 · Kurtis E. Bachman, Pedram Argani, et al. · Cancer Biology & Therapy · 664

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Binding of Ras to Phosphoinositide 3-Kinase p110α Is Required for Ras- Driven Tumorigenesis in Mice

2007 · Surbhi Gupta, Antoine R. Ramjaun, et al. · Cell · 589

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Activation of phosphoinositide 3‐kinase by interaction with Ras and by point mutation.

1996 · P. Rodriguez‐Viciana, P. H. Warne, et al. · The EMBO Journal · 566

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The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

2007 · Chuan-Hsiang Huang, Diana Mandelker, et al. · Science · 561

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

2008 · Mariona Graupera, Julie Guillermet-Guibert, et al. · Nature · 519

Breast Cancer–Associated PIK3CA Mutations Are Oncogenic in Mammary Epithelial Cells

2005 · Steven J. Isakoff, Jeffrey A. Engelman, et al. · Cancer Research · 509

The Drosophila phosphoinositide 3‐kinase Dp110 promotes cell growth.

1996 · S. J. Leevers, D. Weinkove, et al. · The EMBO Journal · 487

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Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

2006 · Lazaros C. Foukas, Marc Claret, et al. · Nature · 462

Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms

2008 · Li Zhao, Peter K. Vogt · Proceedings of the National Academy of Sciences · 438

PIK3CA as an oncogene in cervical cancer

2000 · Yen-Ying Ma, Sung-Jen Wei, et al. · Oncogene · 434

Cancer-specific mutations in PIK3CA are oncogenic in vivo

2006 · Andreas G. Bader, Sohye Kang, et al. · Proceedings of the National Academy of Sciences · 421

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

2007 · Nabil Miled, Ying Yan, et al. · Science · 412

Rare cancer-specific mutations in PIK3CA show gain of function

2007 · Marco Gymnopoulos, Marc-André Elsliger, et al. · Proceedings of the National Academy of Sciences · 377

Functional Analysis of PIK3CA Gene Mutations in Human Colorectal Cancer

2005 · Tsuneo Ikenoue, Fumihiko Kanai, et al. · Cancer Research · 369

The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells

2005 · Jean J. Zhao, Zhenning Liu, et al. · Proceedings of the National Academy of Sciences · 324

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Oncogenic mutations mimic and enhance dynamic events in the natural activation of phosphoinositide 3-kinase p110α ( PIK3CA )

2012 · John E. Burke, Olga Perisic, et al. · Proceedings of the National Academy of Sciences · 299

A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

2009 · Diana Mandelker, Sandra B. Gabelli, et al. · Proceedings of the National Academy of Sciences · 295

Oncogenic Mutations of PIK3CA in Human Cancers

2010 · Yardena Samuels, Todd Waldman · Current topics in microbiology and immunology · 291

Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer

2016 · Yujun Hao, Yardena Samuels, et al. · Nature Communications · 290

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Works count: 824

Citation count: 33,390