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Keyword

p53 stabilization

Description: The process by which p53 protein is maintained against degradation, increasing its abundance and enabling tumor-suppressive responses in cells.
OpenAlex ID: keywords/p53-stabilization
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
2004 · Lyubomir T. Vassilev, Binh T. Vu, et al. · Science · 4,649
ARF Promotes MDM2 Degradation and Stabilizes p53: ARF-INK4a Locus Deletion Impairs Both the Rb and p53 Tumor Suppression Pathways
1998 · Yanping Zhang, Yue Xiong, et al. · Cell · 1,627
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Modes of p53 Regulation
2009 · Jan-Philipp Kruse, Wei Gu · Cell · 1,608
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The complexity of p53 modulation: emerging patterns from divergent signals
1998 · Amato J. Giaccia, Michael B. Kastan · Genes & Development · 1,314
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DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2
2000 · Atsushi Hirao, Young-Yun Kong, et al. · Science · 1,285
DNA damage activates p53 through a phosphorylation–acetylation cascade
1998 · Kazuyasu Sakaguchi, Julio E. Herrera, et al. · Genes & Development · 1,203
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Distribution and Biological Activities of the Flavonoid Luteolin
2008 · Miguel Lopez-Lazaro · Mini-Reviews in Medicinal Chemistry · 1,105
Mdm2 Is a RING Finger-dependent Ubiquitin Protein Ligase for Itself and p53
2000 · Shengyun Fang, Jane P. Jensen, et al. · Journal of Biological Chemistry · 1,041
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The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites
2000 · Sheau-Yann Shieh, Jinwoo Ahn, et al. · Genes & Development · 972
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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
1998 · Takehiko Kamijo, Jason D. Weber, et al. · Proceedings of the National Academy of Sciences · 899
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
1998 · Won G. An, Meera Kanekal, et al. · Nature · 827
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
2003 · Carlos P. Rubbi, Jo Milner · The EMBO Journal · 811
Chk2/hCds1 functions as a DNA damage checkpoint in G1by stabilizing p53
2000 · Nabil H. Chehab, Asra Malikzay, et al. · Genes & Development · 804
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Regulation ofp53downstream genes
1998 · Wafik S. El-Deiry · Seminars in Cancer Biology · 800
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The p53–Mdm2 module and the ubiquitin system
2002 · Dan Michael, Moshe Oren · Seminars in Cancer Biology · 765
Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents.
1993 · M Fritsche, C Haessler, et al. · PubMed · 749
Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation
2003 · Christopher L Brooks, Wei Gu · Current Opinion in Cell Biology · 743
Mediation of c-Myc-Induced Apoptosis by p53
1994 · Heiko Hermeking, Dirk Eick · Science · 739
Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
1999 · Reiko Honda, Hideyo Yasuda · The EMBO Journal · 723
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NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector
2010 · Albena T. Dinkova-Kostova, Paul Talalay · Archives of Biochemistry and Biophysics · 718
Phosphorylation of human p53 by p38 kinase coordinates N‐terminal phosphorylation and apoptosis in response to UV radiation
1999 · Dmitry V. Bulavin, Shińichi Saito, et al. · The EMBO Journal · 711
ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage
2001 · Ruth Maya, Moshe Balass, et al. · Genes & Development · 710
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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.
1993 · S W Lowe, H E Ruley · Genes & Development · 666
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In vivo ubiquitination and proteasome-mediated degradation of p53(1).
1996 · C G Maki, J M Huibregtse, et al. · PubMed · 645
Crystal Structure of a UBP-Family Deubiquitinating Enzyme in Isolation and in Complex with Ubiquitin Aldehyde
2002 · Min Hu, Pingwei Li, et al. · Cell · 642
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Works count: 2,997
Citation count: 141,900
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