Keyword

p62

Description: A designation used for different proteins, including the autophagy receptor p62/SQSTM1 and a p62 protein associated with signaling; its meaning depends on context.

Primary topic: Autophagy in Disease and Therapy (30%)

OpenAlex ID: keywords/p62

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

2017 · Changmeng Cui, Jianzhong Cui, et al. · Cellular Physiology and Biochemistry · 5,203

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p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

2007 · Serhiy Pankiv, Terje Høyvarde Clausen, et al. · Journal of Biological Chemistry · 4,574

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

2005 · Geir Bjørkøy, Trond Lamark, et al. · The Journal of Cell Biology · 3,272

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

2010 · Sven Geisler, Kira M. Holmström, et al. · Nature Cell Biology · 2,831

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

2015 · Michael Lazarou, Danielle A. Sliter, et al. · Nature · 2,760

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

2010 · Daniel F. Egan, David B. Shackelford, et al. · Science · 2,586

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

2010 · Masaaki Komatsu, Hirofumi Kurokawa, et al. · Nature Cell Biology · 2,408

Homeostatic Levels of p62 Control Cytoplasmic Inclusion Body Formation in Autophagy-Deficient Mice

2007 · Masaaki Komatsu, Satoshi Waguri, et al. · Cell · 2,125

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Activation of the p62‐Keap1‐NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

2015 · Xiaofang Sun, Zhanhui Ou, et al. · Hepatology · 2,004

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Selective autophagy mediated by autophagic adapter proteins

2011 · Terje Johansen, Trond Lamark · Autophagy · 1,731

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Autophagy Suppresses Tumorigenesis through Elimination of p62

2009 · Robin Mathew, Cristina M. Karp, et al. · Cell · 1,720

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p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription

2010 · Ashish Jain, Trond Lamark, et al. · Journal of Biological Chemistry · 1,466

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

2012 · Chong-Shan Shi, Kevin Shenderov, et al. · Nature Immunology · 1,366

Autophagy-deficient mice develop multiple liver tumors

2011 · Akito Takamura, Masaaki Komatsu, et al. · Genes & Development · 1,341

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A Role for Ubiquitin in Selective Autophagy

2009 · Vladimir Kirkin, David G. McEwan, et al. · Molecular Cell · 1,240

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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

2016 · Zhenyu Zhong, Atsushi Umemura, et al. · Cell · 1,195

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A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates

2009 · Vladimir Kirkin, Trond Lamark, et al. · Molecular Cell · 1,155

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Chapter 12 Monitoring Autophagic Degradation of p62/SQSTM1

2009 · Geir Bjørkøy, Trond Lamark, et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 1,143

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

2009 · Jorge Moscat, Maria T. Diaz-Meco · Cell · 1,073

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The mechanisms and roles of selective autophagy in mammals

2022 · Jose Norberto S. Vargas, Maho Hamasaki, et al. · Nature Reviews Molecular Cell Biology · 1,022

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Interactions between Autophagy Receptors and Ubiquitin-like Proteins Form the Molecular Basis for Selective Autophagy

2014 · Vladimir Rogov, Volker Dötsch, et al. · Molecular Cell · 992

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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

2015 · Chanhee Kang, Qikai Xu, et al. · Science · 981

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

2015 · Elizabeth T. Cirulli, Brittany N. Lasseigne, et al. · Science · 964

p62 links the autophagy pathway and the ubiqutin–proteasome system upon ubiquitinated protein degradation

2016 · Wei Jing Liu, Lin Ye, et al. · Cellular & Molecular Biology Letters · 915

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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy

2015 · Jin-Mi Heo, Alban Ordureau, et al. · Molecular Cell · 901

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Works count: 15,890

Citation count: 459,600