Keyword

PAD4

Description: A protein associated with peptidyl arginine deimination, studied in immune responses, inflammatory disease, and reproductive biology.

Primary topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms (22%)

OpenAlex ID: keywords/pad4

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

2009 · Yanming Wang, Ming Li, et al. · The Journal of Cell Biology · 1,527

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PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

2010 · Pingxin Li, Ming Li, et al. · The Journal of Experimental Medicine · 1,490

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Diabetes primes neutrophils to undergo NETosis, which impairs wound healing

2015 · Siu Ling Wong, Melanie Demers, et al. · Nature Medicine · 1,262

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

2003 · Akari Suzuki, Ryo Yamada, et al. · Nature Genetics · 1,168

Human PAD4 Regulates Histone Arginine Methylation Levels via Demethylimination

2004 · Yanming Wang, Joanna Wysocka, et al. · Science · 1,012

Thrombosis: tangled up in NETs

2013 · Kimberly Martinod, Denisa D. Wagner · Blood · 869

Histone Deimination Antagonizes Arginine Methylation

2004 · Graeme L. Cuthbert, Sylvain Daujat, et al. · Cell · 841

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Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

2015 · Huw D Lewis, John Liddle, et al. · Nature Chemical Biology · 783

Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice

2017 · Braedon McDonald, Rachelle P. Davis, et al. · Blood · 664

Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4

2001 · Bart J. Feys, Lisa J. Moisan, et al. · The EMBO Journal · 629

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Plant immunity: the EDS1 regulatory node

2005 · Marcel Wiermer, Bart J Feys, et al. · Current Opinion in Plant Biology · 624

EDS5, an Essential Component of Salicylic Acid–Dependent Signaling for Disease Resistance in Arabidopsis, Is a Member of the MATE Transporter Family

2002 · Christiane Nawrath, Silvia Heck, et al. · The Plant Cell · 604

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Network Properties of Robust Immunity in Plants

2009 · Kenichi Tsuda, Masanao Sato, et al. · PLoS Genetics · 603

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Molecular and Cellular Mechanisms of Cardiovascular Disorders in Diabetes

2016 · Manasi S. Shah, Michael Brownlee · Circulation Research · 602

Isolation of Arabidopsis Mutants With Enhanced Disease Susceptibility by Direct Screening

1996 · Jane Glazebrook, Elizabeth E Rogers, et al. · Genetics · 602

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Arabidopsis thaliana PAD4 encodes a lipase-like gene that is important for salicylic acid signaling

1999 · Dayadevi Jirage, Tina L. Tootle, et al. · Proceedings of the National Academy of Sciences · 595

Molecular mechanisms of NET formation and degradation revealed by intravital imaging in the liver vasculature

2015 · Elzbieta Kolaczkowska, Craig N. Jenne, et al. · Nature Communications · 583

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Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

2008 · Indira Neeli, Salar N Khan, et al. · The Journal of Immunology · 565

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Replication of Putative Candidate-Gene Associations with Rheumatoid Arthritis in >4,000 Samples from North America and Sweden: Association of Susceptibility with PTPN22, CTLA4, and PADI4

2005 · Robert M. Plenge, Leonid Padyukov, et al. · The American Journal of Human Genetics · 564

Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells

2008 · D Makrygiannakis, M Hermansson, et al. · Annals of the Rheumatic Diseases · 550

Damage‐associated molecular pattern–activated neutrophil extracellular trap exacerbates sterile inflammatory liver injury

2015 · Hai Huang, Samer Tohme, et al. · Hepatology · 540

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

2020 · Lijing Kang, Huilin Yu, et al. · Nature Communications · 535

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Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

2013 · Kimberly Martinod, Melanie Demers, et al. · Proceedings of the National Academy of Sciences · 533

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Arabidopsis local resistance to Botrytis cinerea involves salicylic acid and camalexin and requires EDS4 and PAD2, but not SID2, EDS5 or PAD4

2003 · Simone Ferrari, Julia M. Plotnikova, et al. · The Plant Journal · 532

Neutrophil extracellular traps — the dark side of neutrophils

2016 · Ole E. Sørensen, Niels Borregaard · Journal of Clinical Investigation · 531

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Works count: 2,782

Citation count: 91,970