Keyword

PALB2

Description: A human protein-coding gene involved in homologous recombination DNA repair and associated with inherited susceptibility to breast, ovarian, and other cancers.

Primary topic: BRCA gene mutations in cancer (62%)

Wikidata ID: wiki/Q18046302

OpenAlex ID: keywords/palb2

Whole genomes redefine the mutational landscape of pancreatic cancer

2015 · Australian Pancreatic Cancer Genome Initiative, Nicola Waddell, et al. · Nature · 2,643

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Inherited DNA-Repair Gene Mutations in Men with Metastatic Prostate Cancer

2016 · Colin C. Pritchard, Joaquin Mateo, et al. · New England Journal of Medicine · 1,680

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

2009 · Sohrab P. Shah, Ryan D. Morin, et al. · Nature · 1,069

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

2006 · Nazneen Rahman, Sheila Seal, et al. · Nature Genetics · 1,003

Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing

2011 · Tom Walsh, Silvia Casadei, et al. · Proceedings of the National Academy of Sciences · 933

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

2010 · Mary Ellen Moynahan, Maria Jasin · Nature Reviews Molecular Cell Biology · 930

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

2015 · Rohit Prakash, Yu Zhang, et al. · Cold Spring Harbor Perspectives in Biology · 868

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Control of BRCA2 Cellular and Clinical Functions by a Nuclear Partner, PALB2

2006 · Bing Xia, Qing Sheng, et al. · Molecular Cell · 862

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Breast-Cancer Risk in Families with Mutations in PALB2

2014 · Antonis C. Antoniou, Silvia Casadei, et al. · New England Journal of Medicine · 852

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Pathogenic Germline Variants in 10,389 Adult Cancers

2018 · Kuan-lin Huang, R. Jay Mashl, et al. · Cell · 836

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Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

2009 · Siân Jones, Ralph H. Hruban, et al. · Science · 826

Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer

2020 · Maha Hussain, Joaquin Mateo, et al. · New England Journal of Medicine · 790

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Inherited Mutations in Women With Ovarian Carcinoma

2015 · Barbara M. Norquist, Maria I. Harrell, et al. · JAMA Oncology · 774

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BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors

2019 · Andrew Lee, Nasim Mavaddat, et al. · Genetics in Medicine · 724

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Hereditary Diffuse Gastric Cancer Syndrome

2015 · Samantha Hansford, Pardeep Kaurah, et al. · JAMA Oncology · 695

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Inherited Mutations in 17 Breast Cancer Susceptibility Genes Among a Large Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer

2014 · Fergus J. Couch, Steven N. Hart, et al. · Journal of Clinical Oncology · 673

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins

2007 · Weidong Wang · Nature Reviews Genetics · 663

Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

2006 · Sarah Reid, Detlev Schindler, et al. · Nature Genetics · 645

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

2009 · Shirley M. H. Sy, Michael S. Y. Huen, et al. · Proceedings of the National Academy of Sciences · 615

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer

2017 · Fergus J. Couch, Hermela Shimelis, et al. · JAMA Oncology · 613

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Association Between Inherited Germline Mutations in Cancer Predisposition Genes and Risk of Pancreatic Cancer

2018 · Chunling Hu, Steven N. Hart, et al. · JAMA · 577

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PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

2009 · Feng Zhang, Jianglin Ma, et al. · Current Biology · 562

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Frequency of Germline Mutations in 25 Cancer Susceptibility Genes in a Sequential Series of Patients With Breast Cancer

2016 · Nadine Tung, Nancy U. Lin, et al. · Journal of Clinical Oncology · 556

Pan-cancer landscape of homologous recombination deficiency

2020 · Luan Nguyen, John W. M. Martens, et al. · Nature Communications · 530

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A mutational signature reveals alterations underlying deficient homologous recombination repair in breast cancer

2017 · Paz Polak, Jaegil Kim, et al. · Nature Genetics · 529

Works count: 3,472

Citation count: 75,490