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Keyword

PARP2

Description: A human gene encoding poly(ADP-ribose) polymerase 2, an enzyme involved in DNA repair and cellular responses to damage.
Wikidata ID: wiki/Q18034972
OpenAlex ID: keywords/parp2
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
2012 · Junko Murai, Shar-yin N. Huang, et al. · Cancer Research · 2,197
The PARP superfamily
2004 · Jean‐Christophe Amé, Catherine Spenlehauer, et al. · BioEssays · 1,459
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PARP inhibition: PARP1 and beyond
2010 · Michèle Rouleau, Anand Patel, et al. · Nature reviews. Cancer · 1,294
New insights into the molecular and cellular functions of poly(ADP-ribose) and PARPs
2012 · Bryan A. Gibson, W. Lee Kraus · Nature Reviews Molecular Cell Biology · 1,215
ABT-888, an Orally Active Poly(ADP-Ribose) Polymerase Inhibitor that Potentiates DNA-Damaging Agents in Preclinical Tumor Models
2007 · Cherrie K. Donawho, Yan Luo, et al. · Clinical Cancer Research · 774
Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib
2013 · Junko Murai, Shar-Yin N. Huang, et al. · Molecular Cancer Therapeutics · 757
PARP-2, A Novel Mammalian DNA Damage-dependent Poly(ADP-ribose) Polymerase
1999 · Jean-Christophe Amé, Véronique Rolli, et al. · Journal of Biological Chemistry · 745
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Poly(ADP-ribose) Polymerase-2 (PARP-2) Is Required for Efficient Base Excision DNA Repair in Association with PARP-1 and XRCC1
2002 · Valérie Schreiber, Jean-Christophe Amé, et al. · Journal of Biological Chemistry · 705
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Functional interaction between PARP‐1 and PARP‐2 in chromosome stability and embryonic development in mouse
2003 · Josiane Ménissier de Murcia, Michelle Ricoul, et al. · The EMBO Journal · 627
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination
2009 · Helen E Bryant, Eva Petermann, et al. · The EMBO Journal · 602
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases
2007 · Paul, O. Hassa · Frontiers in bioscience · 584
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Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?
2000 · Sydney Shall, Gilbert de Murcia · Mutation Research/DNA Repair · 534
The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art
2012 · Mike De Vos, Valérie Schreiber, et al. · Biochemical Pharmacology · 492
Proteome-wide Identification of Poly(ADP-Ribosyl)ation Targets in Different Genotoxic Stress Responses
2013 · Stephanie Jungmichel, Florian Rosenthal, et al. · Molecular Cell · 374
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Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors
2016 · Ann-Gerd Thorsell, Torun Ekblad, et al. · Journal of Medicinal Chemistry · 358
Serine ADP-Ribosylation Depends on HPF1
2017 · Juan José Bonfiglio, Pietro Fontana, et al. · Molecular Cell · 348
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Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
2009 · Matthias Altmeyer, Simon Messner, et al. · Nucleic Acids Research · 325
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Discovery of 2-{4-[(3S)-Piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): A Novel Oral Poly(ADP-ribose)polymerase (PARP) Inhibitor Efficacious in BRCA-1 and -2 Mutant Tumors
2009 · Philip Jones, Sergio Altamura, et al. · Journal of Medicinal Chemistry · 316
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cells
2007 · Oliver Mortusewicz, Jean-Christophe Amé, et al. · Nucleic Acids Research · 316
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Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase
2007 · Anna E. O. Fisher, Helfrid Hochegger, et al. · Molecular and Cellular Biology · 314
The Role of PARP-1 and PARP-2 Enzymes in Metabolic Regulation and Disease
2012 · Péter Bai, Carles Cantó · Cell Metabolism · 309
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Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3
2014 · Carole Beck, Isabelle Robert, et al. · Experimental Cell Research · 302
Resistance to PARP inhibitors by SLFN11 inactivation can be overcome by ATR inhibition
2016 · Junko Murai, Ying Feng, et al. · Oncotarget · 298
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The role of poly(ADP-ribose) in the DNA damage signaling network
2005 · Maria Malanga, Felix R Althaus · Biochemistry and Cell Biology · 275
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Discovery of the Poly(ADP-ribose) Polymerase (PARP) Inhibitor 2-[(R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide (ABT-888) for the Treatment of Cancer
2008 · Thomas D. Penning, Gui-Dong Zhu, et al. · Journal of Medicinal Chemistry · 268
Works count: 1,364
Citation count: 39,280
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