Keyword

Patched

Description: Patched is a gene encoding a receptor in the Hedgehog signaling pathway, best known for regulating embryonic patterning in Drosophila and other animals.

Primary topic: Hedgehog Signaling Pathway Studies (53%)

OpenAlex ID: keywords/patched

Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome

1996 · Heidi Hahn, Carol Wicking, et al. · Cell · 2,022

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Activating Smoothened mutations in sporadic basal-cell carcinoma

1998 · Jingwu Xie, Maximilien Murone, et al. · Nature · 1,334

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

2000 · Jussi Taipale, James K. Chen, et al. · Nature · 1,312

Hepatogastroenterology

2011 · Yidong Cai, Haoxuan Zheng, et al. · Hepatogastroenterology · 1,257

The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog

1996 · Donna M. Stone, Mary Hynes, et al. · Nature · 1,106

Gli2 and Gli3 Localize to Cilia and Require the Intraflagellar Transport Protein Polaris for Processing and Function

2005 · Courtney J Haycraft, Boglarka Banizs, et al. · PLoS Genetics · 902

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Dual Roles for Patched in Sequestering and Transducing Hedgehog

1996 · Yu Chen, Gary Struhl · Cell · 900

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Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 · L V Goodrich, R L Johnson, et al. · Genes & Development · 824

Murine Model of Niemann-Pick C Disease: Mutation in a Cholesterol Homeostasis Gene

1997 · Stacie K. Loftus, Jill A. Morris, et al. · Science · 801

Patched acts catalytically to suppress the activity of Smoothened

2002 · J. Taipale, M. K. Cooper, et al. · Nature · 794

Sertoli cell signaling by Desert hedgehog regulates the male germline

1996 · Mark J Bitgood, Liya Shen, et al. · Current Biology · 688

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Purkinje-cell-derived Sonic hedgehog regulates granule neuron precursor cell proliferation in the developing mouse cerebellum

1999 · Valerie A. Wallace · Current Biology · 648

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Hedgehog is a signaling protein with a key role in patterning Drosophila imaginal discs

1994 · Tetsuya Tabata, Thomas B. Kornberg · Cell · 615

The Drosophila smoothened Gene Encodes a Seven-Pass Membrane Protein, a Putative Receptor for the Hedgehog Signal

1996 · Joy Alcedo, Marina Ayzenzon, et al. · Cell · 598

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

2004 · Carly Leung, Merel Lingbeek, et al. · Nature · 543

Hedgehog Induces Opposite Changes in Turnover and Subcellular Localization of Patched and Smoothened

2000 · Natalie Denef, Dagmar Neubüser, et al. · Cell · 531

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Small-molecule modulators of Hedgehog signaling: identification and characterization of Smoothened agonists and antagonists

2002 · Maria Frank-Kamenetsky, Xiaoyan M Zhang, et al. · Journal of Biology · 488

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A freely diffusible form of Sonic hedgehog mediates long-range signalling

2001 · Xin Zeng, John A. Goetz, et al. · Nature · 484

Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1

1999 · Priit Kogerman, Thomas Grimm, et al. · Nature Cell Biology · 476

Targeted expression of the signaling molecule decapentaplegic induces pattern duplications and growth alterations in Drosophila wings.

1994 · J. Capdevila, I. Guerrero · The EMBO Journal · 444

The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease

2000 · Elisabeth H. Villavicencio, David O. Walterhouse, et al. · The American Journal of Human Genetics · 436

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Loss of the retrograde motor for IFT disrupts localization of Smo to cilia and prevents the expression of both activator and repressor functions of Gli

2005 · Scott R. May, Amir M. Ashique, et al. · Developmental Biology · 428

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Missense mutations in SMOH in sporadic basal cell carcinomas of the skin and primitive neuroectodermal tumors of the central nervous system.

1998 · J Reifenberger, M Wolter, et al. · PubMed · 426

Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3

1998 · Michael C. Naski, Jennifer S. Colvin, et al. · Development · 420

The hedgehog signaling network

2003 · M. Michael Cohen, · American Journal of Medical Genetics Part A · 418

Works count: 1,013

Citation count: 59,570