Keyword

PD-1

Description: An inhibitory immune checkpoint protein on cells, especially T cells, that regulates immune responses and is targeted in cancer therapy.

Primary topic: Cancer Immunotherapy and Biomarkers (39%)

Wikidata ID: wiki/Q21208025

OpenAlex ID: keywords/pd-1

PD-1 and PD-L1 Immune Checkpoint Blockade to Treat Breast Cancer

2016 · Andreas D. Hartkopf, Florin-Andrei Taran, et al. · Breast Care · 30,845

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The blockade of immune checkpoints in cancer immunotherapy

2012 · Drew M. Pardoll · Nature reviews. Cancer · 13,808

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Cancer immunotherapy using checkpoint blockade

2018 · Antoni Ribas, Jedd D. Wolchok · Science · 6,744

PD-1 and Its Ligands in Tolerance and Immunity

2008 · Mary E. Keir, Manish J. Butte, et al. · Annual Review of Immunology · 5,371

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Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

2000 · Gordon J. Freeman, Andrew J. Long, et al. · The Journal of Experimental Medicine · 5,282

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Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade

2017 · Pornpimol Charoentong, Francesca Finotello, et al. · Cell Reports · 5,028

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Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

2017 · Anthony B El-Khoueiry, Bruno Sangro, et al. · The Lancet · 4,278

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

2015 · Suzanne L. Topalian, Charles G. Drake, et al. · Cancer Cell · 4,216

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Restoring function in exhausted CD8 T cells during chronic viral infection

2005 · Daniel L. Barber, E. John Wherry, et al. · Nature · 3,987

Multiple significance tests: the Bonferroni method

1995 · J Martin Bland, Douglas G Altman · BMJ · 3,884

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Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

2015 · Chih-Hao Chang, Jing Qiu, et al. · Cell · 3,319

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Induced expression of PD‐1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death.

1992 · Y. Ishida, Y. Agata, et al. · The EMBO Journal · 3,257

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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 · Yoshiko Iwai, Masayoshi Ishida, et al. · Proceedings of the National Academy of Sciences · 3,204

Fundamental Mechanisms of Immune Checkpoint Blockade Therapy

2018 · Spencer C. Wei, Colm R. Duffy, et al. · Cancer Discovery · 3,075

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

2001 · Yvette Latchman, Clive R. Wood, et al. · Nature Immunology · 2,955

Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer

2019 · Matthew D. Hellmann, Luis Paz-Ares, et al. · New England Journal of Medicine · 2,820

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Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

1999 · Hiroyuki Nishimura, Masato Nose, et al. · Immunity · 2,749

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Follicular Helper CD4 T Cells (T FH )

2011 · Shane Crotty · Annual Review of Immunology · 2,734

Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy

2016 · Suzanne L. Topalian, Janis M. Taube, et al. · Nature reviews. Cancer · 2,728

PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression

2006 · Cheryl L. Day, Daniel E. Kaufmann, et al. · Nature · 2,680

Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)

2020 · Bo Diao, Chenhui Wang, et al. · Frontiers in Immunology · 2,473

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PD-L1 (B7-H1) and PD-1 pathway blockade for cancer therapy: Mechanisms, response biomarkers, and combinations

2016 · Weiping Zou, Jedd D. Wolchok, et al. · Science Translational Medicine · 2,402

MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

2014 · Thomas Powles, Joseph Paul Eder, et al. · Nature · 2,382

Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

2017 · J.B.A.G. Haanen, F. Carbonnel, et al. · Annals of Oncology · 2,364

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CTLA-4 and PD-1 Pathways

2015 · Elizabeth I. Buchbinder, Anupam Desai · American Journal of Clinical Oncology · 2,357

Works count: 29,490

Citation count: 877,100