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Keyword

PDE10A

Description: A human protein-coding gene encoding phosphodiesterase 10A, an enzyme involved in regulating intracellular cyclic nucleotide signaling.
Wikidata ID: wiki/Q5864325
OpenAlex ID: keywords/pde10a
Sequencing Chromosomal Abnormalities Reveals Neurodevelopmental Loci that Confer Risk across Diagnostic Boundaries
2012 · Michael E. Talkowski, Jill A. Rosenfeld, et al. · Cell · 577
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Quantitative comparison of phosphodiesterase mRNA distribution in human brain and peripheral tissues
2010 · Viktor Lakics, Eric H. Karran, et al. · Neuropharmacology · 463
Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)
1999 · Kotomi Fujishige, Jun Kotera, et al. · Journal of Biological Chemistry · 404
Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A
1999 · Scott H. Soderling, Sharon J. Bayuga, et al. · Proceedings of the National Academy of Sciences · 374
Immunohistochemical localization of PDE10A in the rat brain
2003 · Thomas F Seeger, Brenda Bartlett, et al. · Brain Research · 334
Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum
2008 · Akinori Nishi, Mahomi Kuroiwa, et al. · Journal of Neuroscience · 286
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Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia
2008 · C.J. Schmidt, D.S. Chapin, et al. · Journal of Pharmacology and Experimental Therapeutics · 284
Inhibition of the striatum-enriched phosphodiesterase PDE10A: A novel approach to the treatment of psychosis
2006 · Judith A. Siuciak, Douglas S. Chapin, et al. · Neuropharmacology · 278
Immunohistochemical Localization of Phosphodiesterase 10A in Multiple Mammalian Species
2006 · Timothy M. Coskran, Daniel Morton, et al. · Journal of Histochemistry & Cytochemistry · 251
A Meta-Analysis of Thyroid-Related Traits Reveals Novel Loci and Gender-Specific Differences in the Regulation of Thyroid Function
2013 · Eleonora Porcu, Marco Medici, et al. · PLoS Genetics · 233
Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function
2006 · Judith A. Siuciak, Sheryl A. McCarthy, et al. · Neuropharmacology · 231
Isolation and characterization of PDE10A, a novel human 3′, 5′-cyclic nucleotide phosphodiesterase
1999 · K. Loughney, P.B. Snyder, et al. · Gene · 208
Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).
2009 · Patrick R. Verhoest, Douglas S. Chapin, et al. · Journal of Medicinal Chemistry · 205
Cellular and subcellular localization of PDE10A, a striatum-enriched phosphodiesterase
2006 · Z. Xie, W.O. Adamowicz, et al. · Neuroscience · 198
Physiological and Genetic Adaptations to Diving in Sea Nomads
2018 · Melissa A. Ilardo, Ida Moltke, et al. · Cell · 194
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Striatum‐ and testis‐specific phosphodiesterase PDE10A
1999 · Kotomi Fujishige, Jun Kotera, et al. · European Journal of Biochemistry · 188
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Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington′s disease transgenic mice prior to the onset of motor symptoms
2004 · A.L.O Hebb, H.A Robertson, et al. · Neuroscience · 172
Cyclic nucleotide signaling changes associated with normal aging and age-related diseases of the brain
2017 · Michy P. Kelly · Cellular Signalling · 150
Mechanisms for the Modulation of Dopamine D1 Receptor Signaling in Striatal Neurons
2011 · Akinori Nishi, Mahomi Kuroiwa, et al. · Frontiers in Neuroanatomy · 148
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Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
2016 · Qiao Fan, Virginie J. M. Verhoeven, et al. · Nature Communications · 140
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Confirmed rare copy number variants implicate novel genes in schizophrenia
2010 · Gloria W.C. Tam, Louie N. van de Lagemaat, et al. · Biochemical Society Transactions · 139
Phosphodiesterase 8B Gene Variants Are Associated with Serum TSH Levels and Thyroid Function
2008 · Lisette Arnaud-Lopez, Gianluca Usala, et al. · The American Journal of Human Genetics · 139
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Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a
2018 · Ying Cheng, Zhi-Meng Wang, et al. · Nature Neuroscience · 138
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Vildagliptin Attenuates Huntington's Disease through Activation of GLP-1 Receptor/PI3K/Akt/BDNF Pathway in 3-Nitropropionic Acid Rat Model
2019 · Noha H. Sayed, Nevine Fathy, et al. · Neurotherapeutics · 133
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Resveratrol and curcumin enhance pancreatic β-cell function by inhibiting phosphodiesterase activity
2014 · Michael Rouse, Antoine Younès, et al. · Journal of Endocrinology · 125
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Works count: 1,088
Citation count: 16,910
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